Timing of Moderate Alcohol Exposure During Pregnancy and Neonatal Outcome in Rhesus Monkeys (Macaca mulatta)

Schneider, Mary L.; Moore, Colleen F.; Becker, E.

doi:10.1097/00000374-200108000-00021

Cited by 22 publications

(30 citation statements)

References 48 publications

(34 reference statements)

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“…In animal models, gestational stress has been demonstrated to increase the effects of prenatal alcohol exposure on offspring behavior (Schneider et al, 2001a). However, because a similar alcohol/EF relationship was found in the Streissguth sample (Streissguth et al, 1989) of middle-class social drinkers, the findings of the two studies can be considered together to suggest a more general effect.…”

Section: Discussionmentioning

confidence: 97%

Executive Functioning in Preschool-Age Children Prenatally Exposed to Alcohol, Cocaine, and Marijuana

Noland¹,

Singer²,

Arendt³

et al. 2003

Alcoholism: Clinical & Experimental Research

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Background-Reports from clinical and experimental (animal) research converge on the suggestion that prenatal exposure to alcohol, cocaine, or marijuana undermines executive functioning (EF) and its neurological underpinnings. However, large, adequately controlled, prospective studies of alcohol and marijuana effects on EF have reported conflicting findings, and there have been no such studies of cocaine exposure.

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Section: Discussionmentioning

confidence: 97%

Executive Functioning in Preschool-Age Children Prenatally Exposed to Alcohol, Cocaine, and Marijuana

Noland¹,

Singer²,

Arendt³

et al. 2003

Alcoholism: Clinical & Experimental Research

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“…These measures of early neuromotor activity are important, as they have been associated with later cognitive functioning. Schnieder et al, 38 found low neonatal motor scores correlated with poor performance on a nonmatching-to-sample cognitive test during adolescence in rhesus macaques. Furthermore, animals exposed to prenatal alcohol showed motor deficits similar to those in our ISO-3 subjects.…”

Section: Discussionmentioning

confidence: 99%

Isoflurane Anesthesia Has Long-term Consequences on Motor and Behavioral Development in Infant Rhesus Macaques

Coleman

Robertson

Dissen

et al. 2017

Survey of Anesthesiology

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Background-Experimental evidence correlates anesthetic exposure during early development with neuronal and glial injury and death as well as behavioral and cognitive impairments in young animals. Several, although not all, retrospective human studies of neurocognitive and behavioral disorders following childhood exposure to anesthesia suggest a similar association. Few studies have specifically investigated the effects of infant anesthesia exposure on subsequent

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“…The second goal was to examine whether prenatal exposure to alcohol, stress, or both would alter withdrawal responses (aversion) to repeated tactile stimulation in rhesus monkeys. Our studies to date indicate that rhesus infants from both prenatal stressand prenatal alcohol-exposed pregnancies exhibited reduced neonatal orienting and motor maturity (Schneider, 1992;Schneider, Moore, & Becker, 2001;Schneider, Roughton, & Lubach, 1997), increased stress hormone reactivity (Clarke, Wittwer, Abbott, & Schneider, 1994;Schneider, Moore, & Kraemer, 2004), learning deficits (Schneider, Moore, & Kraemer, 2001), and altered striatal DA system function (Roberts et al, 2004;Schneider et al, 2005). …”

mentioning

confidence: 80%

“…The rearing conditions and previous testing of these subjects were described in detail elsewhere Schneider, Moore, & Becker, 2001). Briefly, all infant monkeys were housed with their mothers in individual cages during the first 6 months of life.…”

Section: Methods Subjectsmentioning

confidence: 99%

Sensory Processing Disorder in a Primate Model: Evidence From a Longitudinal Study of Prenatal Alcohol and Prenatal Stress Effects

et al. 2008

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Disrupted sensory processing, characterized by over-or underresponsiveness to environmental stimuli, has been reported in children with a variety of developmental disabilities. This study examined the effects of prenatal stress and moderate-level prenatal alcohol exposure on tactile sensitivity and its relationship to striatal dopamine system function in thirty-eight 5-to 7-year-old rhesus monkeys. The monkeys were from four experimental conditions: (a) prenatal alcohol exposed, (b) prenatal stress, (c) prenatal alcohol exposed + prenatal stress, and (d) sucrose controls. Increased D 2 receptor binding in the striatum, evaluated using positron emission tomography neuroimaging, was related to increased withdrawal (aversion) responses to repetitive tactile stimuli and reduced habituation across trials. Moreover, prenatal stress significantly increased overall withdrawal responses to repetitive tactile stimulation compared to no prenatal stress.Sensory processing disorders, characterized by under-or overresponsiveness to sensory stimulation that most individuals perceive as harmless (Ayres & Robbins, 1979) NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript estimated to occur in 5% of the general population (Ahn, Miller, Milberger, & McIntosh, 2004) and seem to pose a unique challenge for people with developmental disabilities (Baranek, 2002), including autism, attention deficit hyperactivity disorder (ADHD), fragile X syndrome, and other developmental disabilities (Ayres & Tickle, 1980;Baranek, 1999;Baranek & Berkson, 1994;Baranek, Foster, & Berkson, 1997;Cermak & Daunhauer, 1997;Grandin, 1992;Kinnealey, 1973;Larson, 1982;Mangeot et al., 2001;Miller et al., 1999). Understanding the neurobiological processes associated with sensory processing disruptions is important to developing appropriate preventative and intervention approaches.This study examined whether disrupted sensory processing occurs in monkeys as a result of prenatal exposure to alcohol and/or stress, and if so, whether it would be associated with dopamine functioning in the striatum assessed with positron emission tomography (PET) neuroimaging. We employed a primate model for these studies because in human studies causal conclusions are difficult to reach due to confounding variables. Even with the best statistical analyses it is difficult, if not impossible, to separate completely the effects of variables associated with alcohol use, such as psychological stress, tobacco use, or chaotic home life, from the effects of fetal alcohol exposure per se. Nonhuman primates also have the advantage of gestation characteristics and early development similar to the human, and their shorter life span makes longitudinal studies somewhat easier to conduct. Rhesus monkeys were used because of the large amount of available data on their behavior and development in laboratory settings (Harlow & Harlow, 1969;Suomi, 1997) A. Jean Ayres (1964), an occupational therapist and educational psychologist, coined the term "tactile defensiveness" t...

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Timing of Moderate Alcohol Exposure During Pregnancy and Neonatal Outcome in Rhesus Monkeys (Macaca mulatta)

Cited by 22 publications

References 48 publications

Executive Functioning in Preschool-Age Children Prenatally Exposed to Alcohol, Cocaine, and Marijuana

Executive Functioning in Preschool-Age Children Prenatally Exposed to Alcohol, Cocaine, and Marijuana

Isoflurane Anesthesia Has Long-term Consequences on Motor and Behavioral Development in Infant Rhesus Macaques

Sensory Processing Disorder in a Primate Model: Evidence From a Longitudinal Study of Prenatal Alcohol and Prenatal Stress Effects

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