Timing of clopidogrel loading dose on peripheral blood endothelial progenitor cells, SDF-1α and neointimal hyperplasia in carotid stenting

Stolfo, Giuseppe Di; Mastroianno, Sandra; Ruggieri, Maurizio; Fontana, Andrea; Marinucci, Roberto; Copetti, Massimiliano; Minervini, Maria Marta; Savino, Lucia; Mastroianno, Mario; Savino, Maria; Pacilli, Michele Antonio; Mauro, Lazzaro Di; Potenza, Domenico; Cascavilla, Nicola; Paroni, Giulia; Russo, Angelo

doi:10.3233/ch-180429

Cited by 2 publications

(1 citation statement)

References 32 publications

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“…On the other side, the administration of nitric oxide donors such as organic nitrates and/or physical exercise may actually increase the counts of CD133+, CD34+ and vascular endothelial growth factor receptor positive cells, as well as their proliferation activity, adhesion and migration ability in patients with coronary artery disease [62]. Finally, the impact of various other pharmacological interventions on the number and function of PCs has also been shown, including statins, angiotensin converting enzyme inhibitors, angiotensin blockers, beta-blockers and clopidogrel [63,64]. Risk factors also interact with these responses.…”

Section: Progenitor Cells Counts and Outcome After Stentingmentioning

confidence: 99%

Restenosis after Coronary Stent Implantation: Cellular Mechanisms and Potential of Endothelial Progenitor Cells (A Short Guide for the Interventional Cardiologist)

Gori¹

2022

Cells

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Coronary stents are among the most common therapies worldwide. Despite significant improvements in the biocompatibility of these devices throughout the last decades, they are prone, in as many as 10–20% of cases, to short- or long-term failure. In-stent restenosis is a multifactorial process with a complex and incompletely understood pathophysiology in which inflammatory reactions are of central importance. This review provides a short overview for the clinician on the cellular types responsible for restenosis with a focus on the role of endothelial progenitor cells. The mechanisms of restenosis are described, along with the cell-based attempts made to prevent it. While the focus of this review is principally clinical, experimental evidence provides some insight into the potential implications for prevention and therapy of coronary stent restenosis.

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Section: Progenitor Cells Counts and Outcome After Stentingmentioning

confidence: 99%

Restenosis after Coronary Stent Implantation: Cellular Mechanisms and Potential of Endothelial Progenitor Cells (A Short Guide for the Interventional Cardiologist)

Gori¹

2022

Cells

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The slow releasing hydrogen sulfide donor GYY4137 reduces neointima formation upon FeCl3 injury of the carotid artery in mice

Grambow

Klee

Klar

et al. 2020

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INTRODUCTION: Neointima formation is closely linked to vascular stenosis and occurs after endothelial damage. Hydrogen sulfide is an endogenous pleiotropic mediator with numerous positive effects on the cardio vascular system. OBJECTIVE: This study evaluates the effect of the slow releasing hydrogen sulfide donor GYY4137 (GYY) on neointimal formation in vivo. METHODS: The effect of GYY on neointimal formation in the carotid artery was studied in the FeCl3 injury model in GYY- or vehicle-treated mice. The carotid arteries were studied at days 7 and 21 after treatment by means of histology and immunohistochemistry for proliferating cell nuclear antigen (PCNA) and alpha smooth muscle actin (α-SMA). RESULTS: GYY treatment significantly reduced the maximal diameter and the area of the newly formed neointima on both days 7 and 21 when compared to vehicle treatment. GYY additionally reduced the number of PCNA- and α-SMA-positive cells within the neointima on day 21 after FeCl3 injury of the carotid artery. CONCLUSIONS: Summarizing, single treatment with the slow releasing hydrogen sulfide donor GYY reduced the extent of the newly formed neointima by affecting the cellular proliferation at the site of vascular injury.

show abstract

Timing of clopidogrel loading dose on peripheral blood endothelial progenitor cells, SDF-1α and neointimal hyperplasia in carotid stenting

Cited by 2 publications

References 32 publications

Restenosis after Coronary Stent Implantation: Cellular Mechanisms and Potential of Endothelial Progenitor Cells (A Short Guide for the Interventional Cardiologist)

Restenosis after Coronary Stent Implantation: Cellular Mechanisms and Potential of Endothelial Progenitor Cells (A Short Guide for the Interventional Cardiologist)

The slow releasing hydrogen sulfide donor GYY4137 reduces neointima formation upon FeCl3 injury of the carotid artery in mice

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