Timely coordinated phototherapy mediated by mesoporous organosilica coated triangular gold nanoprisms

Liu, Wenfei; Tian, Ying; Zhang, Yunlei; Li, Kai; Zhao, Shuang; Zhang, Junjie; Su, Yunyan; Zhao, Ying; Tang, Yuxia; Sun, Jing; Tian, Wei; Liu, Song; Teng, Zhaogang; Wang, Shouju; Lu, Guangming

doi:10.1039/c8tb00541a

Cited by 13 publications

(7 citation statements)

References 49 publications

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“…Compared to our previous formula based on gold nanoparticles, this nanosystem is biodegradable and easy to synthesize. 6,32 Therefore, we believe that PDMN-Ce6, as a biomimetic, biocompatible and effective platform, holds great promise for MRI/PAI-guided tumor synergetic phototherapy.…”

Section: Resultsmentioning

confidence: 99%

Photosensitizer-loaded biomimetic platform for multimodal imaging-guided synergistic phototherapy

et al. 2018

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Section: Resultsmentioning

confidence: 99%

Photosensitizer-loaded biomimetic platform for multimodal imaging-guided synergistic phototherapy

et al. 2018

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“…Lu et al . constructed a novel nanocomposite (TNP@MOS) (Figure 13A), of which AuTNPs were chosen as the core owing to its high photothermal conversion efficiency ( η ≈70 %), while the outer was coated with mesoporous silica shell with benzene ring bridging [94] . TGP@MOS had position to highly load the photosensitizer molecule zinc phthalocyanine (ZnPc) through π ‐ π stacking interactions as well as hydrophobic interactions, and minimized the premature leakage of 1 O 2 .…”

Section: Applications Of Autnpsmentioning

confidence: 99%

“…Lu et al constructed a novel nanocomposite (TNP@MOS) (Figure 13A), of which AuTNPs were chosen as the core owing to its high photothermal conversion efficiency (η � 70 %), while the outer was coated with mesoporous silica shell with benzene ring bridging. [94] TGP@MOS had position to highly load the photosensitizer molecule zinc phthalocyanine (ZnPc) through π-π stacking interactions as well as hydrophobic interactions, and minimized the premature leakage of 1 O 2 . The obtained TGP@MOS-ZnPc achieved timely synergistic PDT and PTT in a single irradiation, thereby stabilizing and maximizing the in vitro and in vivo efficacy of phototherapy, and significantly improving the therapeutic effects of breast cancer.…”

Section: Phototherapymentioning

confidence: 99%

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Gold Triangular Nanoprisms: Anisotropic Plasmonic Materials with Unique Structures and Properties

2023

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As a novel type of anisotropic inorganic nanomaterials, gold triangular nanoprisms (AuTNPs) have been widely studied for their well‐defined structures and excellent plasmonic properties. This review starts with synthetic methodology, combing through the early thermal solution method to the mature seed‐mediated method and seedless method. The possible mechanisms proposed by predecessors and the problems needed to be solved are also arranged. Along with this, the important morphological evolution process of AuTNPs during synthesis and post‐synthesis stages are revealed, which is of great significance for further understanding the structure of AuTNPs and developing new synthesis strategies. Finally, the applications of AuTNPs, especially associated with plasmonic properties, are listed and summarized where surface‐enhanced Raman scattering (SERS), catalysis, phototherapy and biosensor are included, so that researchers can quickly comprehend the current situation, and provide a basis for further development and exploration of AuTNPs.

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“…In this context, MON-containing photosensitizer molecules present excellent features for PDT applications, as their high porosity allows oxygen to diffuse in and out of the nanoparticles, combined with excellent biocompatibility. − In the course of our work concerning the use of periodic mesoporous organosilica nanoparticles (PMONPs) for PDT − and photochemical internalization (PCI) of small interfering RNA (siRNA), , we focus here on a new class of PMONPs, which is periodic mesoporous ionosilica nanoparticles (PMINPs). Due to their morphological and chemical polyvalence, ionosilicas appear as a particularly versatile class of periodic mesoporous organosilicas .…”

Section: Introductionmentioning

confidence: 99%

Periodic Mesoporous Ionosilica Nanoparticles for Green Light Photodynamic Therapy and Photochemical Internalization of siRNA

Mezghrani

Ali

Richeter

et al. 2021

ACS Appl. Mater. Interfaces

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We report Periodic Mesoporous Ionosilica Nanoparticles (PMINPs) as versatile nano-objects for imaging, photodynamic therapy (PDT), and efficient adsorption and delivery of siRNA into breast cancer cells. In order to endow these nanoparticles PDT and siRNA photochemical internalization (PCI) properties, a porphyrin derivative was integrated into the ionosilica framework. For this purpose, we synthesized PMINPs via hydrolysis-cocondensation procedures from oligosilylated ammonium and porphyrin precursors. The formation of these nanoobjects was attested by TEM. The formed nanoparticles were then thoroughly characterized via solid state NMR, nitrogen sorption, DLS, UV-Vis and fluorescence spectroscopy. Our results indicate the formation of highly porous nanorods with a length of 108 ± 9 nm and a width of 54 ± 4 nm. A significant PDT effect of type I mechanism (95 ± 2.8% of cell death) was observed upon green light irradiation in nanoparticles treated-breast cancer cells, while the blue light irradiation caused a significant phototoxic effect in non-treated cells. Furthermore, PMINPs formed stable complexes with siRNA (up to 24 h), which were efficiently internalized into the cells after 4 h of incubation mostly with energy-dependent endocytosis process. The PCI effect was obvious with green light irradiation and successfully led to 83 ± 1.1% silencing of luciferase gene in luciferase expressing breast cancer cells, while no gene silencing effect was observed with blue light irradiation. The present work highlights the high potential of porphyrin-doped PMINPs as multifunctional nanocarriers for nucleic acids, such as siRNA, with a triple ability to perform imaging, PDT and PCI.

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Timely coordinated phototherapy mediated by mesoporous organosilica coated triangular gold nanoprisms

Abstract: Mesoporous organosilica coated triangular gold nanoprisms for timely coordinated phototherapy.

Cited by 13 publications

References 49 publications

Photosensitizer-loaded biomimetic platform for multimodal imaging-guided synergistic phototherapy

Photosensitizer-loaded biomimetic platform for multimodal imaging-guided synergistic phototherapy

Gold Triangular Nanoprisms: Anisotropic Plasmonic Materials with Unique Structures and Properties

Periodic Mesoporous Ionosilica Nanoparticles for Green Light Photodynamic Therapy and Photochemical Internalization of siRNA

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