Photosensitizer-loaded biomimetic platform for multimodal imaging-guided synergistic phototherapy

Tian, Ying; Zhao, Ying; Liu, Wenfei; Liu, Ying; Tang, Yuxia; Teng, Zhaogang; Zhang, Chenyu; Wang, Shouju; Lu, Guangming

doi:10.1039/c8ra04663h

Cited by 5 publications

(4 citation statements)

References 32 publications

(37 reference statements)

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“…It is hence very interesting that PTT-PDT synergistic therapy can be, at least in principle, simply achieved by functionalizing MNP with PS. Also for this application surface control is important and Tian et al adopted PEG modification to improve tumor-targeting ability, circulation time and biocompatibility of MNP [ 221 ]. Their PDMN–Ce6 NP were formed by the successful surface loading of Ce6 to PDA NP via π-π stacking, which were afterwards PEGylated.…”

Section: Mnp Based Therapy and Theranosticsmentioning

confidence: 99%

Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics

et al. 2020

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Bioinspired nanomaterials are ideal components for nanomedicine, by virtue of their expected biocompatibility or even complete lack of toxicity. Natural and artificial melanin-based nanoparticles (MNP), including polydopamine nanoparticles (PDA NP), excel for their extraordinary combination of additional optical, electronic, chemical, photophysical, and photochemical properties. Thanks to these features, melanin plays an important multifunctional role in the design of new platforms for nanomedicine where this material works not only as a mechanical support or scaffold, but as an active component for imaging, even multimodal, and simple or synergistic therapy. The number of examples of bio-applications of MNP increased dramatically in the last decade. Here, we review the most recent ones, focusing on the multiplicity of functions that melanin performs in theranostics platforms with increasing complexity. For the sake of clarity, we start analyzing briefly the main properties of melanin and its derivative as well as main natural sources and synthetic methods, moving to imaging application from mono-modal (fluorescence, photoacoustic, and magnetic resonance) to multi-modal, and then to mono-therapy (drug delivery, anti-oxidant, photothermal, and photodynamic), and finally to theranostics and synergistic therapies, including gene- and immuno- in combination to photothermal and photodynamic. Nanomedicine aims not only at the treatment of diseases, but also to their prevention, and melanin in nature performs a protective action, in the form of nanopigment, against UV-Vis radiations and oxidants. With these functions being at the border between nanomedicine and cosmetics nanotechnology, recently examples of applications of artificial MNP in cosmetics are increasing, paving the road to the birth of the new science of nanocosmetics. In the last part of this review, we summarize and discuss these important recent results that establish evidence of the interconnection between nanomedicine and cosmetics nanotechnology.

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Section: Mnp Based Therapy and Theranosticsmentioning

confidence: 99%

Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics

et al. 2020

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“…Synthetic melanin nanoparticles (SMNPs) are an important class of biobased synthesized nanomaterials that have been used as multimodal imaging agents, , photothermal agents, , drug-delivery systems for chemotherapy, and in the fabrication of stimuli-responsive films . In humans, melanins play a diverse role in biological functions such as coloration, chelation, photoprotection, thermoregulation, and quenching of free radicals .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Ultrasmall Synthetic Melanin Nanoparticles by UV Irradiation in Acidic and Neutral Conditions

Lemaster

Jeevarathinam

Kumar

et al. 2019

ACS Appl. Bio Mater.

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Synthetic melanin nanoparticles have value in metal chelation, photoprotection, and biocompatibility. Applications of these materials have been reported in optics, biomedicine, and electronics. However, precise size control has remained relatively difficult especially for materials below 1000 nm. In this paper we describe the synthesis of ultrasmall synthetic nanoparticles with size of 9.4−31.4 nm in weakly acidic and neutral conditions via UV-irradiation. Size control of these particles was possible by varying the pH from 6.4− 10.0. We then used UV−vis, FTIR, and nuclear magnetic resonance to investigate the mechanism of UV-induced polymerization. The data show that reactive oxygen species from UV irradiation oxidizes intermediates of the reaction and accelerates the formation of these synthetic melanin structures.

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“…PDMNs were prepared based on the reported approach. , The transmission electron microscope (TEM) images revealed that the PDMNs had a spherical shape with an average diameter of approximately 100 nm, and the small-molecule JQ1 loaded onto the PDMN via π–π stacking interactions did not significantly change its size and dispersion from the PDMN-JQ1 TEM (Figure a). As shown in Figure b, the representative absorption peaks of JQ1 were also found in the Fourier transform infrared spectroscopy (FT-IR) spectrum of PDMN-JQ1.…”

Section: Resultsmentioning

confidence: 99%

JQ1-Loaded Polydopamine Nanoplatform Inhibits c-MYC/Programmed Cell Death Ligand 1 to Enhance Photothermal Therapy for Triple-Negative Breast Cancer

Tian¹,

Wang²,

Zhao³

et al. 2019

ACS Appl. Mater. Interfaces

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Programmed cell death ligand 1 (PD-L1) blockade has achieved great success in cancer immunotherapy; however, the response of triple-negative breast cancer (TNBC) to PD-L1 antibodies is limited. To address this challenge, we use the bromodomain and extra-terminal inhibitor JQ1 to down-regulate the expression of PD-L1 and thus elicit the immune response to TNBC instead of using antibodies to block PD-L1. JQ1 also inhibits the growth of TNBC as a targeted therapeutic agent by inhibiting the BRD4-c-MYC axis. The polydopamine nanoparticles (PDMNs) are introduced as a biodegradable and adaptable platform to load JQ1 and induce photothermal therapy (PTT) as another synergistic therapeutic modality. Because the JQ1-loaded PDMNs (PDMN-JQ1) are self-degradable and release JQ1 continuously, this synergistic treatment can lead to remarkable activation of cytotoxic T lymphocytes and induce a strong immune-memory effect to protect mice from tumor re-challenge. Taken together, our study demonstrates a compact and simple nanoplatform for triple therapy, including targeted therapy, PTT, and immunotherapy, for TNBC treatment.

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Photosensitizer-loaded biomimetic platform for multimodal imaging-guided synergistic phototherapy

Abstract: Photodynamic therapy (PDT) has attracted much attention as a strategy for tumor therapy.

Cited by 5 publications

References 32 publications

Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics

Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics

Synthesis of Ultrasmall Synthetic Melanin Nanoparticles by UV Irradiation in Acidic and Neutral Conditions

JQ1-Loaded Polydopamine Nanoplatform Inhibits c-MYC/Programmed Cell Death Ligand 1 to Enhance Photothermal Therapy for Triple-Negative Breast Cancer

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