Time Trends in the Prevalence of Allergic Diseases in Childhood

Geraldini, Marcos; Riedi, Carlos Antônio; Leopoldino, B.B.; Rosário, Cristine Secco; Barkema, F.; Palermo, Filippo; Macedo, Gisele; Kusano, L.D.K.; Eiras, N.O.; Robl, Renata; Schnekenberg, Ricardo Parolin; Ribeiro, Tatiane Bomfim; Macedo, Vaz de

doi:10.1016/j.jaci.2009.12.153

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“…Considering the question on having had four or more episodes of ocular pruritus in the past 12 months the prevalence of current allergic conjunctivitis was 20.7%. This question had a sensitivity of 85.4% and specificity of 85.2% [17].…”

Section: Epidemiologymentioning

confidence: 99%

Epidemiology of allergic conjunctivitis

Rosário

Bielory²

2011

Current Opinion in Allergy &Amp; Clinical Immunology

137

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Section: Epidemiologymentioning

confidence: 99%

Epidemiology of allergic conjunctivitis

Rosário

Bielory²

2011

Current Opinion in Allergy &Amp; Clinical Immunology

137

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“…The prevalence of allergic disease have increased dramatically in the last few decades [891011]. Multiple environmental chemicals such as pesticides, solvents, and air pollutants have been associated with increased incidences of allergy [12].…”

Section: Introductionmentioning

confidence: 99%

Imidacloprid inhibits IgE-mediated RBL-2H3 cell degranulation and passive cutaneous anaphylaxis

Shi

Zou

Gao

et al. 2016

Asia Pacific Allergy

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BackgroundImidacloprid has been commonly used as a pesticide for crop protection and acts as nicotinic acetylcholine receptor agonists. Little information about the relationship between imidacloprid and allergy is available.ObjectiveThis study aims to examine the effects of imidacoprid on IgE-mediated mast cell activation.MethodsThe rat basophilic leukemia cell line RBL-2H3 (RBL-2H3 cells) were treated with 10-3 – 10-12 mol/L imidacloprid, followed by measuring the mediator production, influx of Ca2+ in IgE-activated RBL-2H3 cells, and the possible effects of imidacoprid on anti-dinitrophenyl IgE-induced passive cutaneous anaphylaxis (PCA).ResultsIt was shown that imidacoprid suppressed the production of histamine, β-hexosaminidase, leukotriene C4, interleukin-6, tumor necrosis factor-α, and Ca2+ mobilization in IgE-activated RBL-2H3 cells and decreased vascular extravasation in IgE-induced PCA.ConclusionIt is the first time to show that imidacloprid suppressed the activation of RBL-2H3 cells.

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Time Trends in the Prevalence of Allergic Diseases in Childhood

Cited by 2 publications

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Epidemiology of allergic conjunctivitis

Epidemiology of allergic conjunctivitis

Imidacloprid inhibits IgE-mediated RBL-2H3 cell degranulation and passive cutaneous anaphylaxis

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