Time Trends in the Incidence of Parkinson Disease

Savica, Rodolfo; Grossardt, Brandon R.; Bower, James H.; Ahlskog, J. Eric; Rocca, Walter A.

doi:10.1001/jamaneurol.2016.0947

Cited by 216 publications

(210 citation statements)

References 32 publications

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“…Old age is the best known risk for developing PS and the PD [17][18][19][20][21][22]. Individuals over the age of 80 years have been classified as "very old" [20].…”

Section: Introductionmentioning

confidence: 99%

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Parkinson's Disease in the Very Old - Clinicopathological Observations

Rajput¹,

Ef²

2017

Journal of Neuroscience and Neuropsychology

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Background:The incidence of Parkinson syndrome (PS) increases dramatically after age 80 years. As the number of the very old (>80 years) is rising in the population, the number of PS cases would increase. In the general population the most common variant of PS is the Parkinson's disease (PD). PD is characterized by marked loss of substantia nigra neurons and Lewy Body (LB) inclusions. All the pathological variants of PS in the elderly however remain unknown. The objective of this study was to determine the frequency of different PS variants and their course in the elderly individuals.

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“…Old age is the best known risk for developing PS and the PD [17][18][19][20][21][22]. Individuals over the age of 80 years have been classified as "very old" [20].…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, the proportion of the elderly population has increased at a faster rate than the growth of the general population [17,21,22]. Some experts have predicted rising future healthcare needs for PS cases [22].…”

Section: Introductionmentioning

confidence: 99%

Parkinson's Disease in the Very Old - Clinicopathological Observations

Rajput¹,

Ef²

2017

Journal of Neuroscience and Neuropsychology

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“…The study used prevalence data for projection because of the lack of reliable data on PD incidence and survival in most of the countries studied. If, indeed, PD incidence has been increasing at the rates suggested by the Savica et al study, 1 we would have to revise this estimate to an even larger number, presenting an enormous challenge to our health care system. Effective planning for this possibility will therefore be needed.…”

mentioning

confidence: 97%

“…The Rochester Epidemiology Project has documented medical visits for most residents in Olmstead County, Minnesota, since the mid-1960s. In the Savica et al study, 1 the investigators identified a total of 275 male and 189 female residents with PD between 1976 and 2005 by reviewing decades of medical records. Parkinson disease cases were identified and adjudicated according to an established protocol, and in addition, the study used a subset of study participants to validate the diagnosis with postmortem neuropathological assessment and showed excellent agreement.…”

mentioning

confidence: 99%

“…For example, 2 publications 5,6 used the same national insurance database in Taiwan and examined PD incidence over similar periods but used different algorithms to define PD and reached opposite conclusions: PD incidence increased in one study 5 and decreased in the other. 6 To our knowledge, the Savica et al study 1 is the first to examine long-term trends in PD incidence. The Rochester Epidemiology Project is uniquely suited for this type of research.…”

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confidence: 99%

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Are We Ready for a Potential Increase in Parkinson Incidence?

Chen

2016

JAMA Neurol

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Association of Levels of Physical Activity With Risk of Parkinson Disease

et al. 2018

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Key Points Question What is the association between physical activity and the risk of Parkinson disease? Findings In this systematic review and meta-analysis of more than half a million unique participants, physical activity, particularly moderate to vigorous physical activity, was associated with a significant reduction in Parkinson disease risk. This association was stronger among men than women. Meaning Physical activity may be an important protective factor for preventing the development of Parkinson disease among at-risk men; thus, large prospective studies should be performed to examine this association and to investigate the factors that underlie the observed sex difference.

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Time Trends in the Incidence of Parkinson Disease

Cited by 216 publications

References 32 publications

Parkinson's Disease in the Very Old - Clinicopathological Observations

Parkinson's Disease in the Very Old - Clinicopathological Observations

Are We Ready for a Potential Increase in Parkinson Incidence?

Association of Levels of Physical Activity With Risk of Parkinson Disease

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