Association of Levels of Physical Activity With Risk of Parkinson Disease

Fang, Xuexian; Han, Dan; Cheng, Qi; Zhang, Pan; Zhao, Chunhui; Min, Junxia; Wang, Fudi

doi:10.1001/jamanetworkopen.2018.2421

Cited by 110 publications

(98 citation statements)

References 39 publications

(77 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this review, we focus on aerobic exercise, a type of exercise that involves continuous movements of the body's large muscles in a rhythmic manner for sustained periods, increases heart rate and caloric requirements, and is performed to maintain or improve physical fitness [5]. Different lines of evidence (animal models of PD [6][7][8][9], small human studies [10,11], longitudinal cohort studies [12][13][14][15][16]) underlined the therapeutic potential of aerobic exercise in PD and identified aerobic exercise as a promising form of exercise to study in people with PD. A previous review of clinical trials investigating aerobic exercise in PD concluded that aerobic exercise improves physical fitness in PD, but evidence on diseasespecific effects was lacking [17].…”

Section: Box 1 Exercise Terminology According To the American Collegementioning

confidence: 99%

Current Perspectives on Aerobic Exercise in People with Parkinson's Disease

et al. 2020

View full text Add to dashboard Cite

Parkinson’s disease (PD) is a progressive neurological disorder characterized by motor and non-motor symptoms for which only symptomatic treatments exist. Exercise is a widely studied complementary treatment option. Aerobic exercise, defined as continuous movement of the body’s large muscles in a rhythmic manner for a sustained period that increases caloric requirements and aims at maintaining or improving physical fitness, appears promising. We performed both a scoping review and a systematic review on the generic and disease-specific health benefits of aerobic exercise for people with PD. We support this by a meta-analysis on the effects on physical fitness (VO2max), motor symptoms (Movement Disorder Society Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) motor section), and health-related quality of life (39-item Parkinson’s disease Questionnaire (PDQ-39)). Aerobic exercise has generic health benefits for people with PD, including a reduced incidence of cardiovascular disease, a lower mortality, and an improved bone health. Additionally, there is level 1 evidence that aerobic exercise improves physical fitness (VO2max) and attenuates motor symptoms (MDS-UPDRS motor section) in the off-medication state, although the long-term effects (beyond 6 months) remain unclear. Dosing the exercise matters: improvements appear to be greater after training at higher intensities compared with moderate intensities. We found insufficient evidence for a beneficial effect of aerobic exercise on health-related quality of life (PDQ-39) and conflicting results regarding non-motor symptoms. Compliance to exercise regimes is challenging for PD patients but may be improved by adding exergaming elements to the training program. Aerobic exercise seems a safe intervention for people with PD, although care must be taken to avoid falls in at-risk individuals. Further studies are needed to establish the long term of aerobic exercise, including a focus on non-motor symptoms and health-related quality of life.

show abstract

Section: Box 1 Exercise Terminology According To the American Collegementioning

confidence: 99%

Current Perspectives on Aerobic Exercise in People with Parkinson's Disease

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Results from recent systematic reviews clearly show that higher levels of moderate to vigorous physical activity in mid or later life are associated with lower risk of developing PD . A dose response was observed in men, and the lack of evidence of a dose response in women is likely because of the lower percentage of women included in most studies.…”

Section: The Past 10 Yearsmentioning

confidence: 98%

Environment, lifestyle, and Parkinson's disease: Implications for prevention in the next decade

2019

View full text Add to dashboard Cite

There is evidence from observational studies for a role of a number of environmental exposures and lifestyle habits in modulating the risk for Parkinson's disease. Environmental and lifestyle associations, if causal, represent opportunities for Parkinson's disease prevention or disease modification at individual and population levels. In the past decade, additional evidence has been published that improves causal inference and/or enhances our understanding of the complexity of these associations. A number of gene–environment interactions have been elucidated, and our understanding of the roles of physical activity, pesticide and other chemical exposures, dietary habits, emotional stress, head injury, and smoking has been refined. In the next decade, better techniques will help us to close the gaps in our knowledge, including taking into account Parkinson's disease heterogeneity and gene and risk factor interactions in observational studies. To do this, larger datasets, global consortia, genomewide environment interaction studies, prospective studies throughout the lifespan, and improvements in the methodology of clinical trials of physical activity will be key. Despite the caveats of observational studies, a number of low‐risk and potentially high‐yield recommendations for lifestyle modification could be made to minimize the individual and societal burdens of Parkinson's disease, including dietary modifications, increasing physical activity, and head injury avoidance. Furthermore, a reduction in pesticide use could have a major impact on global health related to and beyond Parkinson's disease. Given the increasing prevalence of this disorder, formulating and promoting these recommendations should be a high priority. © 2019 International Parkinson and Movement Disorder Society

show abstract

“…In a total sample of 498,135 participants conducted by the UK Biobank, the highest risk of death was found in participants with the lowest PA level, and the risk of mortality increased as the PA quantile decreased [45]. The possible explanation may contribute to the beneficial effect that PA was demonstrated can reduce the incidence of chronic diseases [46], Alzheimer disease [47], Parkinson disease [48], and disability [46], which are all FI components, and can reduce mortality in turn. Our research also suggested that SP actively reduced the probability of mortality approximately eightfold in frail participants compared with those who seldom participated in social activities.…”

Section: Discussionmentioning

confidence: 99%

Frailty index–predicted mortality is moderated by health-related behaviors: a 4-year community-based longitudinal-cohort study

Huang¹,

Chen

Bo³

et al. 2020

Preprint

View full text Add to dashboard Cite

To explore the separate and joint associations between frailty and long-term, all-cause mortality with health-related behaviors in older adults. We enrolled a total of 4050 community residents age ≥60 years from Songjiang District, Shanghai, China, and followed up with them every year from 2015 to 2018.Based on the standard procedure for creating an FI, we developed one containing 28 measured variables. Survival analyses were used to examine the risk ratios (RRs) between frailty and 4-year mortality; hazard ratios (HRs) were obtained and adjusted for gender and age. Over an average follow-up time of 1107.56 ± 144.43 days, 216 (5.4%) participants died. Of all participants, 71.7% were non-frail (FI = 0–0.1), 23.2% were pre-frail (FI = 0.1–0.2), and 5.1% were frail (FI ³0.2). Multivariate HRs (with 95% confidence intervals [CIs]) for all-cause mortality were 1.58 (1.06–2.34) and 2.63 (1.52 –4.55) for moderate (FI 0.1–0.2) and severe (FI >0.2) frailty, respectively, compared with mild frailty (<0.1). Risk of death for severely frail participants who were physically inactive (HR = 3.40; 95% CI, 1.78–6.50; P < 0.001) was 105%, much higher than for severely frail participants who performed physical exercise (HR = 2.34; 95% CI, 1.35–4.09; P < 0.01). Similarly, among severely frail participants, those who were socially inactive (HR = 5.77; 95% CI, 2.69–12.38; P < 0.01) were 344% more likely to die than those who regularly participated in social activities (HR = 2.33; 95% CI, 1.42–3.86; P < 0.01).

show abstract

Association of Levels of Physical Activity With Risk of Parkinson Disease

Cited by 110 publications

References 39 publications

Current Perspectives on Aerobic Exercise in People with Parkinson's Disease

Current Perspectives on Aerobic Exercise in People with Parkinson's Disease

Environment, lifestyle, and Parkinson's disease: Implications for prevention in the next decade

Frailty index–predicted mortality is moderated by health-related behaviors: a 4-year community-based longitudinal-cohort study

Contact Info

Product

Resources

About