Time trend analysis of primary liver cancer incidence in Sihui county of Guangdong Province, China (1987–2011)

Liu, Wenyi; Liu, Qing; Huang, Qihong; Lu, Yu-Qiang; Xie, Shiwei; Lin, Aihua; Cao, Su‐Mei

doi:10.1186/s12885-016-2817-9

Cited by 9 publications

(10 citation statements)

References 27 publications

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“…PLC incidence and its temporal trends are heterogeneous by sex and age . Males were deemed to have a 2‐ to 3‐fold higher risk than females for developing PLC, and the incidence trends for the 2 sexes are for the most part not in alignment . The average age at diagnosis of PLC is approximately 60 years .…”

Section: Introductionmentioning

confidence: 99%

“…9,10 Males were deemed to have a 2-to 3-fold higher risk than females for developing PLC, and the incidence trends for the 2 sexes are for the most part not in alignment. 11,12 The average age at diagnosis of PLC is approximately 60 years. 13,14 However, PLC among middle-aged people (age 30-59 years) and even younger populations (age <30 years) is not rare, which causes a heavier disease burden than that of PLC in older patients.…”

Section: Introductionmentioning

confidence: 99%

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Global incidence trends in primary liver cancer by age at diagnosis, sex, region, and etiology, 1990‐2017

Liu

Suo

Mao

et al. 2020

Cancer

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BACKGROUND: The incidence of primary liver cancer (PLC) continues to increase worldwide. The incidence trends and patterns of PLC associated with different age at diagnosis remain unknown. METHODS: We collected detailed information on PLC between 1990 and 2017 from Global Burden of Disease Study 2017. Estimated annual percentage changes in the PLC age-standardized incidence rate (ASR) diagnosed by age, sex, region, and etiology were calculated to quantify the temporal trends in PLC ASR. RESULTS: Globally, the number of PLC cases for which the age at diagnosis was <30 years decreased from 17,381 in 1990 to 14,661 in 2017, whereas the number of PLC cases diagnosed at age 30 to 59 and ≥60 years old increased from 216,561 and 241,189 in 1990 to 359,770 and 578,344 in 2017, respectively. The ASR of PLC cases with age at diagnosis <30 years and between 30 and 59 years decreased in both sexes, whereas the ASR of PLC with age at diagnosis ≥60 years increased in males and remained stable in females at the global level. Males had a more dramatic increase in PLC diagnosed at age ≥60 years but a milder decrease in PLC diagnosed between 30 and 59 years of age. This decrease was attributed largely to the reduction in PLC caused by hepatitis B and hepatitis C and was consistent in most regions except for developed countries, in which the ASR of PLC increased irrespective of sex and age. The ASR of PLC due to nonalcoholic steatohepatitis (NASH) increased by the greatest magnitude in most regions. CONCLUSION: PLC in highly endemic regions has been partly alleviated due to the potent control of hepatitis, especially among young and middle-aged people. However, an unfavorable trend was observed in most developed countries and in elderly populations. As such, PLC prevention schedules should give more attention to NASH and elderly patients. Cancer 2020;126:2267-2278.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Global incidence trends in primary liver cancer by age at diagnosis, sex, region, and etiology, 1990‐2017

Liu

Suo

Mao

et al. 2020

Cancer

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“…However, there is no data on the epidemiology of HCC in mainland China, while these have been widely reported in the United States, Australia, Denmark, Thailand and many other counties and areas [ 4 , 5 , 6 , 7 , 8 , 9 , 10 ]. Only a few studies have reported the incidence and mortality rates of primary liver cancer in some regions of China, including Shanghai, Guangzhou, Shenzhen, Chongqing, Fuzhou, Nantong, Sihui and other cities [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ]. However, almost all of the cities mentioned above are located in the south of China; the changes in prevalence, incidence, and mortality of primary liver cancer have not yet been examined in Northern China, and much less for HCC.…”

Section: Introductionmentioning

confidence: 99%

Trends and Age-Period-Cohort Effects on the Prevalence, Incidence and Mortality of Hepatocellular Carcinoma from 2008 to 2017 in Tianjin, China

Liu

Chang

2021

IJERPH

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Objectives: China is the country most afflicted by hepatocellular carcinoma in the world. However, little is known about the epidemiology of hepatocellular carcinoma in China. This study aimed to examine the trends of the prevalence, incidence, and mortality of hepatocellular carcinoma in China, and to investigate the effects of age, period, and birth cohort on the epidemiological trend. Methods: The data were obtained from the Urban Employee Basic Medical Insurance claims database (2003–2017) in Tianjin, China, which covers 5.95 million individuals. The average annual percentage change of the prevalence, incidence, and mortality were accessed using joinpoint regression. Age-period-cohort models were produced to quantify the effects of age, period, and cohort. Results: The hepatocellular carcinoma prevalence rate increased by 5.13% annually from 20.12/100,000 in 2008 to 30.49/100,000 in 2017, and the incidence rate was almost unchanged, from 13.91/100,000 in 2008 to 14.09/100,000 in 2017, but mortality decreased by 1.80% annually from 8.18/100,000 in 2008 to 7.34/100,000 in 2017. The age-period-cohort analysis revealed that the prevalence rate was remarkably increased from age 25, peaked in age 60, and decreased at age 70 and over. In the period index, the prevalence rate increased gradually from 2008 to 2016, and decreased a little in 2017. In the cohort index, the prevalence rate decreased approximately linearly from the 1925 cohort to the 1990 cohort. The result for the incidence was similar to the prevalence. The mortality rate increased approximately linearly from age 45 to 85, decreased from the 1925 cohort to the 1990 cohort, but it changed a little with the change of period. Conclusions: The findings of this study could inform the necessity of conducting earlier screening for high-risk individuals and improving the treatment of hepatocellular carcinoma, which may also help to predict future changes in hepatocellular carcinoma epidemiology.

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“…The present study showed that PLC was the third most common type of cancer in Guangzhou, with a WASIR of 20.96/100 000 being observed during the period of 2004-2013, which was substantially higher than the global (12.49/100 000) 1 and the national averages (19.28/100 000), 12 and considerably lower than in Sihui (30.80/100 000) 13 and Qidong (41.37/100 000). 14 major risk factor of liver cancer, showed a trend similar to that of liver cancer incidence in males, and could lead to a remarkable difference by sex.…”

Section: Discussionmentioning

confidence: 47%

Time trends and patterns of primary liver cancer in Guangzhou from 2004 to 2015

Lin

et al. 2017

Precision Radiation Oncology

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Objective: To analyze the epidemiological trends and patterns of primary liver cancer (PLC) in Guangzhou, China, between 2004 and, and provide a basis for making control measures and strategies for prevention. Methods:The data were extracted from the population-based database of the Guangzhou Cancer Registry. The crude incidence, world age standardized incidence rate (WASIR), and average annual percentage change were calculated. WASIR was calculated with Segi's population.Results: There were a total of 27 149 cases diagnosed with PLC during 2004−2015, with a sex ratio of 4.14:1 (21 865 males and 5284 females). The crude incidence and WSRIR were 28.57/100 000 and 20.96/100 000, respectively. The average annual percentage change of crude incidence and WASIR were -0.24% (95% CI -1.60 to 1.20) and -2.31% (95% CI -3.50 to -1.10).The age-specific incidence rates declined in all age groups, except for the ≥75 years group. The incidence rate increased rapidly from age 40 years and peaked at the age of 80-84 years. Conclusions:The WASIR of PLC has been decreasing significantly in Guangzhou. However, the incidence is still high, and the prevention and control of PLC should be strengthened.

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Time trend analysis of primary liver cancer incidence in Sihui county of Guangdong Province, China (1987–2011)

Cited by 9 publications

References 27 publications

Global incidence trends in primary liver cancer by age at diagnosis, sex, region, and etiology, 1990‐2017

Global incidence trends in primary liver cancer by age at diagnosis, sex, region, and etiology, 1990‐2017

Trends and Age-Period-Cohort Effects on the Prevalence, Incidence and Mortality of Hepatocellular Carcinoma from 2008 to 2017 in Tianjin, China

Time trends and patterns of primary liver cancer in Guangzhou from 2004 to 2015

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