Global incidence trends in primary liver cancer by age at diagnosis, sex, region, and etiology, 1990‐2017

Liu, Zhenqiu; Suo, Chen; Mao, Xianhua; Jiang, Yanfeng; Jin, Li; Zhang, Tiejun; Chen, Xingdong

doi:10.1002/cncr.32789

Cited by 94 publications

(93 citation statements)

References 37 publications

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“…The treatment of primer liver tumors (hepatocellular carcinoma, HCC) is not sufficiently efficient because of the late recognition [ 1 ]. Chemotherapy alone or combined with surgery or radiotherapy are the most frequent protocols.…”

Section: Introductionmentioning

confidence: 99%

Poly(3-Hydroxybutyrate)-Based Nanoparticles for Sorafenib and Doxorubicin Anticancer Drug Delivery

Babos

Rydz

Kawalec

et al. 2020

IJMS

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Dual drug-loaded nanotherapeutics can play an important role against the drug resistance and side effects of the single drugs. Doxorubicin and sorafenib were efficiently co-encapsulated by tailor-made poly([R,S]-3-hydroxybutyrate) (PHB) using an emulsion–solvent evaporation method. Subsequent poly(ethylene glycol) (PEG) conjugation onto nanoparticles was applied to make the nanocarriers stealth and to improve their drug release characteristics. Monodisperse PHB–sorafenib–doxorubicin nanoparticles had an average size of 199.3 nm, which was increased to 250.5 nm after PEGylation. The nanoparticle yield and encapsulation efficiencies of drugs decreased slightly in consequence of PEG conjugation. The drug release of the doxorubicin was beneficial, since it was liberated faster in a tumor-specific acidic environment than in blood plasma. The PEG attachment decelerated the release of both the doxorubicin and the sorafenib, however, the release of the latter drug remained still significantly faster with increased initial burst compared to doxorubicin. Nevertheless, the PEG–PHB copolymer showed more beneficial drug release kinetics in vitro in comparison with our recently developed PEGylated poly(lactic-co-glycolic acid) nanoparticles loaded with the same drugs.

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Section: Introductionmentioning

confidence: 99%

Poly(3-Hydroxybutyrate)-Based Nanoparticles for Sorafenib and Doxorubicin Anticancer Drug Delivery

Babos

Rydz

Kawalec

et al. 2020

IJMS

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“…Liver cancer is more common among men compared with women, worldwide (4). The most important risk factors for developing liver cancer are hepatitis B and C infections, liver cirrhosis resulting from viral hepatitis, alcohol abuse and non-alcoholic fatty liver disease (NAFLD) (4,8). Recently, the age-standardized incidence rate of primary liver cancer cases increased in men with age at diagnosis ≥60 years, from 241,189 in 1990 to 578,334 in 2017, globally (8).…”

Section: Introductionmentioning

confidence: 99%

“…The most important risk factors for developing liver cancer are hepatitis B and C infections, liver cirrhosis resulting from viral hepatitis, alcohol abuse and non-alcoholic fatty liver disease (NAFLD) (4,8). Recently, the age-standardized incidence rate of primary liver cancer cases increased in men with age at diagnosis ≥60 years, from 241,189 in 1990 to 578,334 in 2017, globally (8). Therefore, more preventive measures should be taken to prevent NAFLD from being the most important risk factor of liver cancer in elderly patients (9).…”

Section: Introductionmentioning

confidence: 99%

New benzenesulphonohydrazide derivatives as potential antitumour agents

et al. 2020

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Cancer treatment remains a serious challenge worldwide. Thus, finding novel antitumour agents is of great importance. In the present study, nine new benzenesulphonohydrazide derivatives (1-9) were synthesized, and the chemical structures of the obtained compounds were confirmed by spectral analysis methods, including IR, 1 H nuclear magnetic resonance (NMR) and 13 C NMR. Experimental lipophilicity values were established using reversed phase-high performance thin layer chromatography. The antiproliferative activity of the synthesized compounds was tested against three tumour cell lines (769-P, HepG2 and NCI-H2170) and one normal cell line (Vero). Among the newly developed molecules, compound 4 exhibited generally the highest cytotoxicity across all tumour cell lines, and it was highly selective. However, higher selectivity towards the tested cancer cell lines was observed using compound 2, when compared with compound 4, which also exhibited significant antiproliferative activity against these tumour cells. In 769-P cells, compounds 5 and 6 were the most selective among all tested compounds. Compound 5 exhibited high cytotoxicity with an estimated IC 50 value of 1.94 µM. In the NCI-H2170 cell line, compound 7 was the most cytotoxic and the most selective. In brief, the combination of fluorine and bromine substituents at the phenyl ring showed the most promising results, exerting high cytotoxicity and selectivity towards cancer cells. The renal adenocarcinoma cell line (769-P) appeared to be the most sensitive to the anticancer properties of the novel benzenesulphonohydrazones.

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“…Primary liver cancer is the sixth most commonly diagnosed cancer and the fourth leading cause of cancer-related death worldwide [1]. There were approximately 841,000 new cases and 782,000 deaths of liver cancer annually [1,2]. Hepatocellular carcinoma (HCC) accounts for about 75%-85% of all liver cancer cases, and most of HCC are diagnosed at an advanced stage, which has lost opportunities to accept curative treatments [3,4,2].…”

Section: Introductionmentioning

confidence: 99%

“…There were approximately 841,000 new cases and 782,000 deaths of liver cancer annually [1,2]. Hepatocellular carcinoma (HCC) accounts for about 75%-85% of all liver cancer cases, and most of HCC are diagnosed at an advanced stage, which has lost opportunities to accept curative treatments [3,4,2]. Although target and immune therapies have developed rapidly in recent years, the prognosis of HCC remains poor [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Ferroptosis Involved in the Progression of Hepatocellular Carcinoma Through Circ0097009/miR-1261/SLC7A11 Axis

Lyu

Zeng

Kong

et al. 2020

Preprint

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Background: Circular RNAs (circRNAs) is a class of non-coding RNAs and have been demonstrated to play important roles in tumorigenesis. Nevertheless, how circRNAs regulate the progression of hepatocellular cancer (HCC) remains unclear.Methods: CircRNA microarrays was performed in HCC tissues to screen circRNAs that are extinct expressed. Quantitative real-time PCR (qRT-PCR) was conducted in HCC cell lines, and tissues and circ0097009 were found to be significantly up-regulated. Then, we explored the functions of circ0097009 in HCC by a series of experiments including cell proliferation, invasion and mouse xenograft assay. Additionally, luciferase assay and RNA immunoprecipitation (RIP) assay was used to explore the interactions of circ0097009, miRNA-1261 and SLC7A11 (a key regulator in cancer cell ferroptosis) in HCC.Results: Microarray analysis and qRT-PCR verified a circRNA circ0097009, which was significantly up-regulated in HCC tissues and cell lines. Knockdown of circ0097009 inhibited proliferation and invasion in HCC. Luciferase reporter assays showed that circ0097009 and SLC7A11 directly bind to miR-1261. Subsequent experiments showed that circ0097009 and SLC7A11 regulated the expression of each other by sponging miR-1261.Conclusions: Circ0097009 act as a competing endogenous RNA (ceRNA) to regulate SLC7A11 expression, a key regulator in cancer cell ferroptosis through sponging miR-1261 in HCC. Circ0097009 may be used as a diagnostic biomarker and potential target for HCC therapy.

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Global incidence trends in primary liver cancer by age at diagnosis, sex, region, and etiology, 1990‐2017

Cited by 94 publications

References 37 publications

Poly(3-Hydroxybutyrate)-Based Nanoparticles for Sorafenib and Doxorubicin Anticancer Drug Delivery

Poly(3-Hydroxybutyrate)-Based Nanoparticles for Sorafenib and Doxorubicin Anticancer Drug Delivery

New benzenesulphonohydrazide derivatives as potential antitumour agents

Ferroptosis Involved in the Progression of Hepatocellular Carcinoma Through Circ0097009/miR-1261/SLC7A11 Axis

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