Time to wound closure in trauma patients with disorders in wound healing is shortened by supplements containing antioxidant micronutrients and glutamine: A PRCT

Immunonutrition: Role in Wound Healing and Tissue Regeneration

“…31 In a controlled trial of 20 trauma patients with wounds that were failing to heal after trauma or surgery, the provision of antioxidant micronutrients and glutamine for 2 weeks resulted in significantly reduced wound closure time. 32 It appears that antioxidants have the capacity to expedite wound healing in certain clinical situations, but further studies are needed to elucidate the role of oxidative stress in wound healing.…”

Oxidative stress in severe pulmonary trauma in critical ill patients. Antioxidant therapy in patients with multiple trauma — a review

“…The antioxidants are compounds that inhibit or slow down the oxidative damage [76−78] brought to a molecule by a free radical [79][80][81]. The antioxidants react in various ways [82] -inhibitors of the oxidative reaction determined by free radicals, saturation with oxygen singlet, blocking the chain of oxidative reactions, transforming hydroxyl-peroxides in stable compounds, inhibiting some pro-oxidative enzymes or through synergy with other antioxidants [77,[83][84][85][86] (Table 1).…”

Micronutrients, Arginine, and Glutamine: Does Supplementation Provide an Efficient Tool for Prevention and Treatment of Different Kinds of Wounds?

“…Since formulations for immunonutrition enriched with arginine, omega-3-fatty acids, and ribonucleic acids lower the risk of several wound complications (fistula, anastomosis, and incision dehiscence) and also the risk of anastomotic dehiscence, 38 these formulations seem to be more efficient for wound healing in critically ill patients than products providing exclusively arginine. Since isolated glutamine 40 as well as glutamine-enriched ONS, providing also antioxidant micronutrients 41 , have shown beneficial effects on wound healing, combined supplementation of glutamine with a range of micronutrients such as vitamin C E, b-carotene, zinc, and selenium seems to be reasonable for the treatment of surgical or traumatic wounds in critically ill patients.…”

“…However, a decrease in oxygen saturation, observed in the placebo group, did not occur in the verum group. 41 …”