Time to abandon the term angiomyolipoma for non-PEComatous angiomyomatous (or angiomatous) oral tumors with adipocytes

Tosios, Konstantinos I.; Koutlas, Ioannis G.; Kyriakopoulos, Vasileios F.; Balta, Maria G.; Theologie-Lygidakis, Nandia; Vardas, Emmanuel P; Iatrou, Ioannis

doi:10.1016/j.tripleo.2010.04.045

Cited by 5 publications

(7 citation statements)

References 35 publications

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“…We fully agree with Tosios et al [18] in that the term 'angiomyolipoma' should be discouraged for angiomyomatous lesions with mature adipocytes, including terms such as 'mucocutaneous' AML coined by Watanabe and Suzuki [8].…”

Section: Discussionsupporting

confidence: 84%

PEComa of the Nose: Report of a Case with Immunohistochemical and Ultrustructural Studies and a Review of the Literature

Afrogheh

Schneider

Bezuidenhout

et al. 2013

Head and Neck Pathol

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Section: Discussionsupporting

confidence: 84%

PEComa of the Nose: Report of a Case with Immunohistochemical and Ultrustructural Studies and a Review of the Literature

Afrogheh

Schneider

Bezuidenhout

et al. 2013

Head and Neck Pathol

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“…Five were in the upper and lower lip, 5 on the palate, 1 in the cheek, and 1 in the tongue. Each one was 2 cm in diameter or smaller 3 . In our case, the angiomyolipoma was 8 cm in diameter.…”

Section: Discussionmentioning

confidence: 48%

“…Each one was 2 cm in diameter or smaller. 3 In our case, the angiomyolipoma was 8 cm in diameter. Because of its size, the tumor affected tongue motility, thus affecting food intake, chewing, swallowing, and understandability of the speech, which is characteristic of other big lingual tumors.…”

Section: Discussionmentioning

confidence: 48%

Huge Angiomyolipoma of the Tongue

Bauer

Alerić

Bujas

2011

Otolaryngol.--head neck surg.

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“…In 2005, three cases initially diagnosed as cutaneous angiomyolipomas were re‐reviewed; all three lacked HMB‐45 expression, and none were associated with tuberous sclerosis . The author proposed that entities such as these represented angioleiomyoma with fat rather than true PEComas; other authors have argued similarly . We agree that most, if not all, of the cases described in the literature as ‘cutaneous angiomyolipoma’ have been erroneously classified and actually represent angioleiomyoma with adipocytes rather than true PEComa.…”

Section: Discussionmentioning

confidence: 97%

“…As smooth muscle tumors and AML/PEComa have different criteria for malignancy, at least in the kidney, the distinction is potentially important . Scattered case reports in the literature of purported cutaneous AML have noted a lack of connection to tuberous sclerosis or a non‐supportive, unusual immunoreactive pattern . In 2005, three cases initially diagnosed as cutaneous angiomyolipomas were re‐reviewed; all three lacked HMB‐45 expression, and none were associated with tuberous sclerosis .…”

Section: Discussionmentioning

confidence: 99%

Incidence of mature adipocytic component within cutaneous smooth muscle neoplasms

2016

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Angioleiomyoma is a benign smooth muscle tumor of the subcutis. The presence of mature adipocytes has been described in this tumor under the rubric of 'angiolipoleiomyoma' or, erroneously, 'angiomyolipoma' (these are not PEComas). Previous studies have found adipocytes in only 2-3% of angioleiomyoma. Anecdotally, the incidence appeared to be greater than this in our practice. Moreover, the presence of adipocytes has not been evaluated in pilar leiomyoma or cutaneous leiomyosarcoma. We searched the pathology archives from 2007 to 2014 for all cutaneous and subcutaneous leiomyoma and leiomyosarcoma; cases were reviewed to confirm the diagnosis and evaluate for mature adipocytes. Seven of 73 total cases (10%) contained mature adipocytes: 1 of 33 pilar leiomyoma (3%), 4 of 22 angioleiomyoma (18%) and 2 of 18 leiomyosarcoma (11%). In our series, the 18% incidence of 'angioleiomyoma with fat' (our preferred terminology) is higher than the previously reported incidence of 2-3%. We also report the rare presence of mature adipocytes within pilar leiomyoma and cutaneous leiomyosarcoma, a finding not previously reported to our knowledge. Mature adipocytes may be present within cutaneous and subcutaneous leiomyomas and leiomyosarcomas and should not detract from the diagnosis or lead to concern for an adipocytic neoplasm or PEComa.

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Time to abandon the term angiomyolipoma for non-PEComatous angiomyomatous (or angiomatous) oral tumors with adipocytes

Cited by 5 publications

References 35 publications

PEComa of the Nose: Report of a Case with Immunohistochemical and Ultrustructural Studies and a Review of the Literature

PEComa of the Nose: Report of a Case with Immunohistochemical and Ultrustructural Studies and a Review of the Literature

Huge Angiomyolipoma of the Tongue

Incidence of mature adipocytic component within cutaneous smooth muscle neoplasms

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