Time-Series Expression Analysis of Epidermal Stem Cells from High Fat Diet Mice

Lu, Ying; Lu, Q Y; Liu, Houlin; Yu, Jixiang; Xin, Chunlei; Liu, Yingping; Liu, Yanfang; Fan, Lei

doi:10.1089/cmb.2019.0172

Cited by 2 publications

(1 citation statement)

References 34 publications

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“…In EpdSCs, HFD induces transcriptional changes in genes controlling extracellular matrix (ECM) and the PI3K pathway [ 201 ], whereas, in NSCs, FAs overload has an inhibitory effect on neurogenesis, mainly due to the impact that HFD-derived inflammatory molecules, such as IKKβ/NFκB, have on NSCs [ 199 ] ( Figure 6 ). A similar mechanism is also responsible for a feed-forward loop causing the loss of hypothalamic appetite-repressing pro-opiomelanocortin (POMC) neurons, favoring an HFD-induced over-eating behavior [ 199 ].…”

Section: Effects Of Specific Diets On Stem Cellsmentioning

confidence: 99%

Role of Diet in Stem and Cancer Stem Cells

Puca

Fedele

Rasio

et al. 2022

IJMS

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Diet and lifestyle factors greatly affect health and susceptibility to diseases, including cancer. Stem cells’ functions, including their ability to divide asymmetrically, set the rules for tissue homeostasis, contribute to health maintenance, and represent the entry point of cancer occurrence. Stem cell properties result from the complex integration of intrinsic, extrinsic, and systemic factors. In this context, diet-induced metabolic changes can have a profound impact on stem cell fate determination, lineage specification and differentiation. The purpose of this review is to provide a comprehensive description of the multiple “non-metabolic” effects of diet on stem cell functions, including little-known effects such as those on liquid-liquid phase separation and on non-random chromosome segregation (asymmetric division). A deep understanding of the specific dietetic requirements of normal and cancer stem cells may pave the way for the development of nutrition-based targeted therapeutic approaches to improve regenerative and anticancer therapies.

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Section: Effects Of Specific Diets On Stem Cellsmentioning

confidence: 99%

Role of Diet in Stem and Cancer Stem Cells

Puca

Fedele

Rasio

et al. 2022

IJMS

View full text Add to dashboard Cite

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Lipid Mediated Regulation of Adult Stem Cell Behavior

Clémot

Demarco

Jones

2020

Front. Cell Dev. Biol.

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Adult stem cells constitute an important reservoir of self-renewing progenitor cells and are crucial for maintaining tissue and organ homeostasis. The capacity of stem cells to self-renew or differentiate can be attributed to distinct metabolic states, and it is now becoming apparent that metabolism plays instructive roles in stem cell fate decisions. Lipids are an extremely vast class of biomolecules, with essential roles in energy homeostasis, membrane structure and signaling. Imbalances in lipid homeostasis can result in lipotoxicity, cell death and diseases, such as cardiovascular disease, insulin resistance and diabetes, autoimmune disorders and cancer. Therefore, understanding how lipid metabolism affects stem cell behavior offers promising perspectives for the development of novel approaches to control stem cell behavior either in vitro or in patients, by modulating lipid metabolic pathways pharmacologically or through diet. In this review, we will first address how recent progress in lipidomics has created new opportunities to uncover stem-cell specific lipidomes. In addition, genetic and/or pharmacological modulation of lipid metabolism have shown the involvement of specific pathways, such as fatty acid oxidation (FAO), in regulating adult stem cell behavior. We will describe and compare findings obtained in multiple stem cell models in order to provide an assessment on whether unique lipid metabolic pathways may commonly regulate stem cell behavior. We will then review characterized and potential molecular mechanisms through which lipids can affect stem cell-specific properties, including self-renewal, differentiation potential or interaction with the niche. Finally, we aim to summarize the current knowledge of how alterations in lipid homeostasis that occur as a consequence of changes in diet, aging or disease can impact stem cells and, consequently, tissue homeostasis and repair.

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Time-Series Expression Analysis of Epidermal Stem Cells from High Fat Diet Mice

Cited by 2 publications

References 34 publications

Role of Diet in Stem and Cancer Stem Cells

Role of Diet in Stem and Cancer Stem Cells

Lipid Mediated Regulation of Adult Stem Cell Behavior

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