Time-Restricted Feeding Enhances Early Atherosclerosis in Hypercholesterolemic Mice

Pan, Chang Yu; Herrero‐Fernández, Beatriz; Almarcha, Celia Borja; Bris, Raquel Gomez; Zorita, Virginia; Saéz, Ángela; Maas, Sanne L.; Pérez-Olivares, Laura; Herrero-Cervera, Andrea; Lemnitzer, Patricia; Avondt, Kristof Van; Silvestre-Roig, Carlos; González-Granado, José-María; Chevre, Raphael; Soehnlein, Oliver

doi:10.1161/circulationaha.122.063184

Cited by 14 publications

(6 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Leptin, also levels fell during 8 weeks of the ADF diet, overall that was linked to a reduction in bodily weight as well as fat percentage [74][75]. Following the ADF diet, there was a substantial reduction of resistance level that was likely linked to a drop in body mass index.…”

Section: Journal For Research In Applied Sciences and Biotechnologymentioning

confidence: 99%

Fasting Relationship with an Immune System and Heart Disease

Abud,

Ahmed

2024

J. Res. Appl. Sci. Biotechnol.

View full text Add to dashboard Cite

One of the most frequent contributors to co-morbidities or death among individuals living with HIV (PLWH) in antiretroviral therapy (ART) is cardiovascular disease (CVD). Vascular cardiovascular disease, arterial disease, stroke, illness, or cardiac cardiac were among the CVDs that over 50% of PLWH are expected to have a greater likelihood of acquiring. The pathological process on such organism varies by shared vulnerabilities, HIV Viral infection itself, or complications of immunosuppressive medication. With this goal, potential non-pharmacological treatments, including dietary practices like intermittent fasting (IF), are now being investigated globally. The academic community is becoming increasingly interested within IF, a common procedure, because of its prospective advantages for improving blood pressure (BP), chronic inflammation, platelet-derived expansion factor AB, blood lipids as well as lipoproteins and blood vessel intima-media dimension, as well as additional cardiovascular health indicators. Because intermittent fasting has inherent features that improve the main heart disease risk variables as well as modulate inflammation responses linked to arterial disorder, lipid per oxidation, as well as ageing, this review can concentrate with investigating the possible advantages of irregular not eating as an alternatives to medication inexpensive approach to reducing the prevalence of heart conditions within HIV individuals on ART. Through the battle towards the rising incidence of cardiovascular diseases through PLWH, short-term fasting regimes require must be further evaluated in research studies as a significant, innovative, as well as affordable coadjutant of ART.

show abstract

Section: Journal For Research In Applied Sciences and Biotechnologymentioning

confidence: 99%

Fasting Relationship with an Immune System and Heart Disease

Abud,

Ahmed

2024

J. Res. Appl. Sci. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…Time of eating interventions have been explored in preclinical models of established cardiovascular disease 127‐131 . Two recent preclinical reports, in particular, have raised concern about the effects of time restricted eating in populations at high cardiovascular risk, such as those undergoing cardiotoxic chemotherapy treatment and individuals at high risk of atherogenesis 132,133 . The safety and efficacy of time of eating interventions in human participants with established cardiovascular disease and the effect of time of eating interventions on major cardiovascular outcomes remain unknown 122 …”

Section: Time Of Eating Interventions In Individuals With Established...mentioning

confidence: 99%

The effect of time of eating on cardiometabolic risk in primary and secondary prevention of cardiovascular disease

Billingsley

2023

Diabetes Metabolism Res

View full text Add to dashboard Cite

Continuous energy restriction is currently considered the first‐line dietary therapy for weight loss in individuals with obesity. Recently, interventions which alter the eating window and time of eating occasions have been explored as means to achieve weight loss and other cardiometabolic improvements such as a reduction in blood pressure, glycaemia, lipids and inflammation. It is unknown, however, whether these changes result from unintentional energy restriction or from other mechanisms such as the alignment of nutrient intake with the internal circadian clock. Even less is known regarding the safety and efficacy of these interventions in individuals with established chronic noncommunicable disease states, such as cardiovascular disease. This review examines the effects of interventions which alter both eating window and time of eating occasions on weight and other cardiometabolic risk factors in both healthy participants and those with established cardiovascular disease. We then summarise the state of existing knowledge and explore future directions of study.

show abstract

“…DR-based approaches have also been demonstrated to reduce body weight, blood pressure and atherogenic lipids in patients with metabolic syndrome as well as to modulate the gut microbiome to promote intestinal regeneration, reduce inflammatory bowel disease and alleviate diabetes-induced cognitive impairment (Liu et al, 2020; Rangan et al, 2019; Wilkinson et al, 2020). In some pre-clinical models, however, TRF was shown to not protect against atherosclerosis whilst IF showed beneficial effects against dyslipidemia and atherogenesis (Chen et al, 2021; Inoue et al, 2021; Mérian et al, 2023; Pan et al, 2023).…”

Section: Main Textmentioning

confidence: 99%

Beneficial effects of intermittent fasting in NASH and subsequent HCC development are executed by concerted PPARα and PCK1 action in hepatocytes

Gallage,

Ali,

Barragan Avila

et al. 2023

Preprint

View full text Add to dashboard Cite

The role and molecular mechanisms of intermittent fasting (IF) in non-alcoholic steatohepatitis (NASH) and its transition to hepatocellular carcinoma (HCC) are unknown. Here, we identified that an IF 5:2 regimen (two non-consecutive days of food deprivation per week), initiated in the active phase of mice, prevents/ameliorates NASH and fibrosis as well as reduces subsequent HCC development without affecting total calorie intake. The timing, length and number of fasting cycles as well as the type of NASH diet were all critical parameters determining the effectiveness of the fasting benefits. Combined proteomic, transcriptomic and metabolomic analyses identified that PPAR alpha and glucocorticoid receptor (GR)-PCK1 act co-operatively as hepatic executors of the fasting response by promoting fatty acid catabolism and gluconeogenesis whilst suppressing anabolic lipogenesis. In line, PPAR alpha targets and PCK1 were reduced in human NASH. Additionally, dynamic [18F]FDG-PET analysis in vivo revealed increased [18F]FDG uptake/retention and enhanced gluconeogenesis in the liver upon fasting (in accordance with PPAR alpha and GR-PCK1 activation) when assessed by compartmental modelling. Hepatocyte-specific GR deletion only partially abrogated the hepatic fasting response. In contrast, the combined knockdown of Ppara and Pck1 in vivo abolished the beneficial outcomes of fasting against inflammation and fibrosis, confirming their causal relationship in integrating systemic signalling in hepatocytes. Notably, PPAR alpha agonist pemafibrate recapitulated key aspects of hepatic fasting signalling at a molecular level. Therefore, IF or pharmacological mimetics of the PPAR alpha and/or GR-PCK1 axis could be a viable intervention against NASH and subsequent liver cancer.

show abstract

Time-Restricted Feeding Enhances Early Atherosclerosis in Hypercholesterolemic Mice

Cited by 14 publications

References 5 publications

Fasting Relationship with an Immune System and Heart Disease

Fasting Relationship with an Immune System and Heart Disease

The effect of time of eating on cardiometabolic risk in primary and secondary prevention of cardiovascular disease

Beneficial effects of intermittent fasting in NASH and subsequent HCC development are executed by concerted PPARα and PCK1 action in hepatocytes

Contact Info

Product

Resources

About