“…Both chemical (related to absorption) and structural (related to scattering) information can be retrieved by photons traveling through the diffusive medium. Numerous applications have been pursued, both in the medical field-ranging from functional brain imaging 2,3 and neuromonitoring, [4][5][6] to cancer diagnostics 7,8 and therapy monitoring, 9,10 -and in industrial sectors such as characterization of food, 11,12 wood, 13,14 and pharmaceuticals. 15,16 A key requirement for such applications to grow and gain a more widespread clinical or industrial acceptance is to achieve a high grade of reliability, reproducibility, accuracy in quantification, and comparability of clinical results.…”