Time-resolved diffused optical characterization of key tissue constituents of human bony prominence locations

Sekar, Sanathana Konugolu Venkata; Farina, Andrea; Martinenghi, Edoardo; Mora, Alberto Dalla; Taroni, Paola; Pifferi, Antonio; Negredo, Eugènia; Escrig, Roser; Rosales, Quim; Lindner, Claus; Pagliazzi, Marco; Durdurán, Turgut

doi:10.1364/ecbo.2015.95380x

Cited by 7 publications

(18 citation statements)

References 11 publications

(4 reference statements)

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“…Subject 1007 is the only subject with a tumor in the muscle. Literature values for water concentrations in tissue vary greatly (Taroni et al, 2007;Sekar et al, 2015b;Pifferi et al, 2004) but with the exception of subjects 1004 and 1007, the water concentrations in this study are similar to those previously reported for other bony locations on the limbs.…”

Section: Discussionsupporting

confidence: 87%

“…Another study used a diffuse optical time resolved transmittance system to measure chromophores for the proximal femur (trochanter), distal and proximal radius, distal and proximal ulna, and calcaneous (Sekar et al, 2015b). Once again, chromophore measurements are very different, even when comparing the proximal femur to the distal femur.…”

Section: Discussionmentioning

confidence: 99%

“…The absorption and reduced scattering coefficients of the patella and bones in the index finger were respectively measured using frequency-domain diffuse optical spectroscopy and tomography (Farzam et al, 2013;Xu et al, 2001). With a time resolved transmittance system, the optical properties for the manubrium, forearm, forehead, and calcaneous were measured in transmission (Pifferi et al, 2004;Sekar et al, 2015b;Sekar et al, 2015a). The optical properties for the forehead, tibia, radius, ulna, and greater trochanter of the femur have also been measured with time resolved reflectance spectroscopy (Matcher et al, 1997;Sekar et al, 2015a;Doornbos et al, 1999).…”

Section: Previous Diffuse Optics Work In Bonementioning

confidence: 99%

“…However, the spectra for myoglobin and hemoglobin are so similar they cannot be separated in this context (Chance et al, 1988). Collagen is also an important component in bone, tendon, cartilage, muscle, and skin (Lodish et al, ) and several groups have added collagen to their fitting procedures (Pifferi et al, 2004;Zhao et al, 2017;Taroni et al, 2007;Sekar et al, 2015a;Sekar et al, 2015b).…”

Section: Limitationsmentioning

confidence: 99%

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Clinical Feasibility of Diffuse Optical Spectroscopic Imaging for Sarcoma

Peterson

2016

Biomedical Optics 2016

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I have the best family and friends. You have created a support network that has allowed me to grow and overcome. I could not have done this without you. Darren, thank you for being my advisor. You have given me freedom to explore and discover. Bang, thank you for being my co-sponsor. You have coached me in the clinic and encouraged me with your unwavering enthusiasm for me and this project. I am grateful to my committee members, Cathie, Elise, and Ji, for guiding this project and me. I would like to acknowledge all members of the BOTLab, past and present, for their friendship and support, especially my fellow DOSI collaborators. Brannon, thank you for curiosity and patience while creating the phantom set. Professor Bigio, from my first year as an academic advisee to my final year as a Ph.D., you have been a steadfast mentor and an example of a student ally and advocate. I had a lot of help from my clinical collaborators. At Montefiore Medical Center and MD Anderson Cancer Center, I would like to acknowledge Drs. Bang Hoang, David Geller, Rui Yang, and Richard Gorlick. Thank you so much for your enthusiasm and support, you have been amazing collaborators. I also want to acknowledge Janet, Jeremy, and Damian, for coordinating measurements, consenting subjects, extracting patient data, documenting IRB amendments, and guiding me and this project. At Boston Medical Center, I would like to thank Liz, Salli, Jill, Meredith, Jen, Joanna, Malti, Debbie, and Nancy for all their help. Liz, I'll miss doing the DOSI-DO with you. For when everything falls apart, thank you Chris, Dan, and Eric at the Electronic Design Facility for helping me put it back together again. From measurements to data processing to repairs, I would also like to thank Anais, Amanda, and Tom for imparting all of their DOSI knowledge and wisdom. Within the Biomedical Engineerv ing Department, I'm so grateful for all the help, support, and laughs from Christen, Will, Allie, Stephanie, Nicole, and Tara.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Previous Diffuse Optics Work In Bonementioning

confidence: 99%

Section: Limitationsmentioning

confidence: 99%

See 2 more Smart Citations

Clinical Feasibility of Diffuse Optical Spectroscopic Imaging for Sarcoma

Peterson

2016

Biomedical Optics 2016

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“…Works by Taroni et al 11 and Provenzano et al 12 showed that collagen density in breast tissues correlates with breast density and accordingly with the risk of breast cancer. Few studies on the noninvasive characterization of collagen in bone tissues 13,14 revealed its future prospects in osteology to complement existing technologies, such as dual-energy x-ray absorptiometry (DXA), for bone pathological diagnosis. Enhanced contrast of collagen absorption was reported using photoacoustics at SWIR wavelengths as compared to the near-infrared region.…”

mentioning

confidence: 99%

Diffuse optical characterization of collagen absorption from 500 to 1700 nm

et al. 2017

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Abstract. Reduction in scattering, high absorption, and spectral features of tissue constituents above 1000 nm could help in gaining higher spatial resolution, penetration depth, and specificity for in vivo studies, opening possibilities of near-infrared diffuse optics in tissue diagnosis. We present the characterization of collagen absorption over a broadband range (500 to 1700 nm) and compare it with spectra presented in the literature. Measurements were performed using a time-domain diffuse optical technique. The spectrum was extracted by carefully accounting for various spectral distortion effects, due to sample and system properties. The contribution of several tissue constituents (water, lipid, collagen, oxy, and deoxy-hemoglobin) to the absorption properties of a collagen-rich in vivo bone location, such as radius distal in the 500-to 1700-nm wavelength region, is also discussed, suggesting bone diagnostics as a potential area of interest.

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Assessment of diabetic small‐fiber neuropathy by using short‐wave infrared hyperspectral imaging

Sheen

Sheu

Wang

et al. 2021

Journal of Biophotonics

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Among patients with type 2 diabetes mellitus (T2DM), the association between hyperspectral imaging (HSI) examination and diabetic neuropathy (DN) is ascertained using HSI of the feet using four types of spectral difference measurements. DN was evaluated by traditional Michigan Neuropathy Screening Instrument (MNSI), evaluation of painful neuropathy (ID-Pain, DN4) and sudomotor function by measuring electrochemical skin conductance (ESC). Of the 120 T2DM patients and 20 healthy adults enrolled, T2DM patients are categorized into normal sudomotor (ESC >60 μS)and sudomotor dysfunction (ESC ≤ 60 μS) groups. Spectral difference analyses reveal significant intergroup differences, whereas traditional examinations cannot distinguish between the two groups. HSI waveform reflectance gradually increases with disease severity, at 1400 to 1600 nm. The area under the curve (AUC) of receiver operating characteristic (ROC) analysis for abnormal ESC is ≥0.8 for all four HSI methods. HSI could be an objective, sensitive, rapid, noninvasive and remote approach to identify early small-fiber DN.diabetic neuropathy (DN), electrochemical skin conductance (ESC), hyperspectral imaging (HSI), short-wave infrared (SWIR), type 2 diabetes mellitus (T2DM)

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Time-resolved diffused optical characterization of key tissue constituents of human bony prominence locations

Cited by 7 publications

References 11 publications

Clinical Feasibility of Diffuse Optical Spectroscopic Imaging for Sarcoma

Clinical Feasibility of Diffuse Optical Spectroscopic Imaging for Sarcoma

Diffuse optical characterization of collagen absorption from 500 to 1700 nm

Assessment of diabetic small‐fiber neuropathy by using short‐wave infrared hyperspectral imaging

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