Time of origin of the neuroblasts in the neural tube of the chick embryo determined by histochemical observation of acetyl - cholinesterase activity.

Miki, Akinori; Atoji, Yasuro; Mizoguti, Humio

doi:10.1267/ahc.14.641

Cited by 11 publications

(2 citation statements)

References 29 publications

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“…Some neuroepithelial sites in the neighborhood of secondary organizers nevertheless revealed low levels of AChE activity. Comparison with published reports using other markers of postmitotic neurons corroborated earlier accounts (e.g., Gerebtzoff, 1959;Filogamo and Marchisio, 1971;Drews, 1975;Miki et al, 1981aMiki et al, , 1981bMiki and Mizoguti, 1982;Mizoguti and Miki, 1985;Layer, 1983; see also Layer and Sporns, 1987;Layer, 1990Layer, , 1991Schlaggar et al, 1993) indicating that most young neurons initiate AChE expression shortly after exiting the ventricular zone (sometimes even whilst still inside it). We found the patchy and heterochronic emergence of the earliest neurons, and the subsequent sequential tangential spread and radial accumulation of neurogenesis at different parts of the neural wall, to be informative about basic anteroposterior (AP) and dorsoventral (DV) subdivisions already presumed to be induced by earlier genetic patterning of the neuroepithelial progenitors.…”

supporting

confidence: 88%

Neuromeric Landmarks in the Rat Midbrain, Diencephalon and Hypothalamus, Compared with Acetylcholinesterase Histochemistry

Puelles

Fernández

Martı́nez-de-la-Torre

2015

The Rat Nervous System

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supporting

confidence: 88%

Neuromeric Landmarks in the Rat Midbrain, Diencephalon and Hypothalamus, Compared with Acetylcholinesterase Histochemistry

Puelles

Fernández

Martı́nez-de-la-Torre

2015

The Rat Nervous System

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“…Another early feature of the neural tube is the development of neurons, initially at the lateral borders of the floor plate. In the chick embryo the first motoand interneurons are recognizable in the cervicobrachial region at 2 days (Lyser 1964;Miki et al 1981;Layer et al 1988;Yaginuma et al 1990), and at 4 days a large number of neurons is present (Fig. lA).…”

Section: Introductionmentioning

confidence: 97%

Development of floor plate, neurons and axonal outgrowth pattern in the early spinal cord of the notochord-deficient chick embryo

1991

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The notochord is probably involved in the development of the neural tube. In this study, a fragment of caudal notochord was extirpated in ovo from chick embryos at 1.5 days of incubation. At 4.5 days a distinct notochord-deficient region at thoracolumbar level was found. Profound effects were seen, especially at the cranial site of this region. Somites were smaller than normal, or even not recognizable, and in some cases the myotomes were fused in the midline. The spinal cord appeared reduced in size and lacked a floor plate. The average amount of spinal cord neurons was 23% of the normal value, the cells being located circularly along the outer margin of the spinal cord, except for the roof plate. Axonal roots left the cord in the ventral midline only. Caudal to this site, neurons or floor plate cells were alternately present in the ventral spinal cord, and axonal roots left bilaterally. In a caudal direction, a normal morphology gradually reappeared. The possibility is discussed that reduction in spinal cord size and amount of neurons is a direct or indirect effect of the absence of the notochord, and that the sclerotome may be involved.(ABSTRACT TRUNCATED AT 250 WORDS)

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Segment‐related, mosaic neurogenetic pattern in the forebrain and mesencephalon of early chick embryos: I. Topography of ache‐positive neuroblasts up to stage HH18

Puelles

Amat

Martı́nez-de-la-Torre

1987

J of Comparative Neurology

259

285

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Histochemical mapping of AChE-positive neuroblasts in sectioned and whole-mounted preparations of the chick embryo mesencephalon and prosencephalon allows a correlation of early neural tube morphogenesis (segmentation, longitudinal compartmentation) with the heterochronic pattern of neurogenesis. One significant finding is that the initial appearance of neuroblasts in the forebrain does not follow neuromeric segmentation, but evolves in parallel with it. Early neuroblasts appear as separate, distinct groups within specific matrix territories at the center of the transverse neuromeric segments. Neighbouring segments display different spatiotemporal patterns of neurogenesis. Overall gradients of differentiation in the rostrocaudal and ventrodorsal directions are absent, whereas a clear-cut segment-related, mosaic pattern becomes evident. Notwithstanding this, gross regularities of heterochrony in the neurogenetic behavior of the different segments lead to a definition of elemental longitudinal compartments of the forebrain and mesencephalon (floor, paramedian, basal, and alar regions) on the basis of precocious differentiation of the basal region and retarded differentiation of the paramedian and alar regions.

show abstract

Time of origin of the neuroblasts in the neural tube of the chick embryo determined by histochemical observation of acetyl - cholinesterase activity.

Cited by 11 publications

References 29 publications

Neuromeric Landmarks in the Rat Midbrain, Diencephalon and Hypothalamus, Compared with Acetylcholinesterase Histochemistry

Neuromeric Landmarks in the Rat Midbrain, Diencephalon and Hypothalamus, Compared with Acetylcholinesterase Histochemistry

Development of floor plate, neurons and axonal outgrowth pattern in the early spinal cord of the notochord-deficient chick embryo

Segment‐related, mosaic neurogenetic pattern in the forebrain and mesencephalon of early chick embryos: I. Topography of ache‐positive neuroblasts up to stage HH18

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