Neuromeric Landmarks in the Rat Midbrain, Diencephalon and Hypothalamus, Compared with Acetylcholinesterase Histochemistry

Puelles, Luis; Fernández, Bárbara; Martı́nez-de-la-Torre, Margaret

doi:10.1016/b978-0-12-374245-2.00002-4

Cited by 8 publications

(13 citation statements)

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“…This is partly because we use the more elaborated model of molecularly distinct progenitor domains reported by Puelles et al ( 2012 ), which was not available to these authors. Croizier et al ( 2011 ) convincingly showed in E14 rat embryos that the early Pmch cells occupy a restricted posterior sector of the classical longitudinal hypothalamic cell cord, which is formed by precociously differentiating basal neurons (Gilbert, 1935 ; Keyser, 1972 ; His, 1892 ; see also Puelles et al, 1987 , 2014 ). Consistently with this interpretation, this band expresses Shh and Nkx2.1 (typical overall basal plate markers), as well as Nkx2.2 (an early longitudinal marker expressed across the alar-basal boundary, thus labeling a subliminal part of the hypothalamic cell cord, as well as a liminal part of the overlying subparaventricular area in the alar plate; Figure 1A ; Puelles and Rubenstein, 2003 ; Puelles et al, 2004 , 2012 ; Figure 8.14B of the 2012 reference).…”

Section: Resultsmentioning

confidence: 99%

“…Another basal progenitor domain producing peptidergic cell types is the arc-shaped perimamillary/periretromamillary area (PM/PRM), which lies ventral to the linear Nkx2.1 / Dlx / Arx / Lhx6/Wnt8b -expressing TuV/RTuV domain (tuberomamillary terminal of Shimogori et al, 2010 ), where histaminergic neurons selectively originate (Puelles et al, 2012 ; Figure 1C ). The PRM/PM area represents a domain with precocious neurogenesis, comparable in this regard to the hypothalamic cell cord (TuD/RTuD; see Puelles et al, 2014 ). It is molecularly distinct from the retarded retromamillary and mamillary areas by its selective expression of Otp and Sim1 , in curious parallelism with the alar paraventricular area (Figure 1C ; Puelles et al, 2012 ).…”

Section: Resultsmentioning

confidence: 99%

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Ontogenesis of peptidergic neurons within the genoarchitectonic map of the mouse hypothalamus

2015

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During early development, the hypothalamic primordium undergoes anteroposterior and dorsoventral regionalization into diverse progenitor domains, each characterized by a differential gene expression code. The types of neurons produced selectively in each of these distinct progenitor domains are still poorly understood. Recent analysis of the ontogeny of peptidergic neuronal populations expressing Sst, Ghrh, Crh and Trh mRNAs in the mouse hypothalamus showed that these cell types originate from particular dorsoventral domains, characterized by specific combinations of gene markers. Such analysis implies that the differentiation of diverse peptidergic cell populations depends on the molecular environment where they are born. Moreover, a number of these peptidergic neurons were observed to migrate radially and/or tangentially, invading different adult locations, often intermingled with other cell types. This suggests that a developmental approach is absolutely necessary for the understanding of their adult distribution. In this essay, we examine comparatively the ontogenetic hypothalamic topography of twelve additional peptidergic populations documented in the Allen Developmental Mouse Brain Atlas, and discuss shared vs. variant aspects in their apparent origins, migrations and final distribution, in the context of the respective genoarchitectonic backgrounds. This analysis should aid ulterior attempts to explain causally the development of neuronal diversity in the hypothalamus, and contribute to our understanding of its topographic complexity in the adult.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Ontogenesis of peptidergic neurons within the genoarchitectonic map of the mouse hypothalamus

2015

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“…Given that our rat data were reported before in some detail, including sectioned specimens [Puelles et al, 2015a], we will just compare their general aspects with the sauropsidian material, and eventually correct or add some interpretive details. We show early rat forebrain AChE patterns at E11 and E11.5 in Figure 8a-e; Figure 8b is a flattened wholemount at E11, and Figure 8f is a graphic reconstruction of the neuromeric ventricular relief at E11.5 (obtained from a series of semithin sagittal sections).…”

Section: -Rat Forebrain Resultsmentioning

confidence: 99%

“…The present research examines heterochronic spatial patterns in the topology of emerging acetylcholinesterase (AChE)-positive young postmitotic neurons in the sauropsidian (chick and lizard) and mammalian (rat) forebrain and hindbrain. We will reexamine and partly reinterpret previously published chick and rat material [Puelles et al, 1987a[Puelles et al, , 2015a, adding unpublished chick forebrain and rat hindbrain results from Amat's [1986] doctoral thesis, and including as well some hitherto unpublished results from our AChE studies on lizard embryos, done in collaboration with C.M. Trujillo.…”

Section: Introductionmentioning

confidence: 99%

Neurogenetic Heterochrony in Chick, Lizard, and Rat Mapped with Wholemount Acetylcholinesterase and the Prosomeric Model

Amat¹,

Martı́nez-de-la-Torre²,

Trujillo³

et al. 2022

Brain Behav Evol

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In the developing brain, the phenomenon of neurogenesis is manifested heterotopically, that is, much the same neurogenetic steps occur at different places with a different timetable. This is due apparently to early molecular regionalization of the neural tube wall in the anteroposterior and dorsoventral dimensions, in a checkerboard pattern of more or less deformed quadrangular histogenetic areas. Their respective fate is apparently specified by a locally specific combination of active/repressed genes known as ‘molecular profile’. This leads to position-dependent differential control of proliferation, neurogenesis, differentiation, and other aspects, eventually in a heterochronic manner across adjacent areal units with sufficiently different molecular profiles. It is not known how fixed these heterochronic patterns are. We reexamined here comparatively early patterns of forebrain and hindbrain neurogenesis in a lizard (Lacerta gallotia galloti), a bird (the chick), and a mammal (the rat), as demonstrated by activation of acetylcholinesterase (AChE). This is an early marker of postmitotic neurons, which leaves unlabeled the neuroepithelial ventricular cells, so that we can examine cleared wholemounts of the reacted brains to have a birds-eye view of the emergent neuronal pattern at each stage. There is overall heterochrony between the basal and alar plates of the brain, a known fact, but, remarkably, heterochrony occurs even within the precocious basal plate among its final anteroposterior neuromeric subdivisions and their internal microzonal subdivisions. Some neuromeric units or microzones are precocious, while others follow suit without any specific spatial order or gradient; other similar neuromeric units remain retarded in the midst of quite advanced neighbors, though they do produce similar neurogenetic patterns at later stages. It was found that some details of such neuromeric heterochrony are species-specific, possibly related to differential morphogenetic properties. Given the molecular causal underpinning of the updated prosomeric model used here for interpretation, we comment on the close correlation between some genetic patterns and the observed AChE differentiation patterns.

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“…In contrast, LHb neurons have rather early birthdates and a short neurogenetic period compared with MHb and other neurons of the thalamic complex (McAllister and Das 1977 ; Angevine 1970 ). Recently, some embryologic data in the rat were reported, suggesting that the LHb (or a portion of it) may in fact originate outside the habenular territory in a caudoventral region of the thalamus, and its neurons secondarily migrate upward into the habenular domain (Puelles et al 2015 ; Beretta et al 2013 ). In that case, a significant part of the LHb might be regarded as not primarily epithalamic, and this observation may offer another explanation why the LHb was correlated more with prethalamic and thalamic nuclei than with MHb in our analysis.…”

Section: Discussionmentioning

confidence: 99%

Molecular anatomy of the thalamic complex and the underlying transcription factors

et al. 2015

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Thalamocortical loops have been implicated in the control of higher-order cognitive functions, but advances in our understanding of the molecular underpinnings of neocortical organization have not been accompanied by similar analyses in the thalamus. Using expression-based correlation maps and the manual mapping of mouse and human datasets available in the Allen Brain Atlas, we identified a few individual regions and several sets of molecularly related nuclei that partially overlap with the classic grouping that is based on topographical localization and thalamocortical connections. These new molecular divisions of the adult thalamic complex are defined by the combinatorial expression of Tcf7l2, Lef1, Gbx2, Prox1, Pou4f1, Esrrg, and Six3 transcription factor genes. Further in silico and experimental analyses provided the evidence that TCF7L2 might be a pan-thalamic specifier. These results provide substantial insights into the “molecular logic” that underlies organization of the thalamic complex.Electronic supplementary materialThe online version of this article (doi:10.1007/s00429-015-1052-5) contains supplementary material, which is available to authorized users.

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Neuromeric Landmarks in the Rat Midbrain, Diencephalon and Hypothalamus, Compared with Acetylcholinesterase Histochemistry

Cited by 8 publications

References 65 publications

Ontogenesis of peptidergic neurons within the genoarchitectonic map of the mouse hypothalamus

Ontogenesis of peptidergic neurons within the genoarchitectonic map of the mouse hypothalamus

Neurogenetic Heterochrony in Chick, Lizard, and Rat Mapped with Wholemount Acetylcholinesterase and the Prosomeric Model

Molecular anatomy of the thalamic complex and the underlying transcription factors

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