Employing co-resonant coupling in dynamic-mode cantilever MEMS sensors has the potential for a significant increase in sensitivity while maintaining a reliable oscillation detection. However, the resulting complex interplay between the micro-and nanocantilever has to be carefully considered for applicationspecific sensor design as it impacts all relevant sensor properties, such as linearity, stability and detectivity. Here, an overview of key parameters, their dependence on the strength of co-resonance and resulting consequences for sensor performance is provided.