Our system is currently under heavy load due to increased usage. We're actively working on upgrades to improve performance. Thank you for your patience.
“…In both conditions, ventilation would mainly occur in the zone of the PV curve where variable tidal volumes increase the mean driving pressure. In addition, Jensen’s theorem foresees that, in non‐injured lungs, variability in tidal volumes would only limit derecruitment, given that no convex portion is present on the PV curve [ 19 ]. Fig.…”
Section: Mechanisms Of Variable Ventilationmentioning
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency medicine 2016. Other selected articles can be found online at http://www.biomedcentral.com/collections/annualupdate2016. Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www.springer.com/series/8901.
“…In both conditions, ventilation would mainly occur in the zone of the PV curve where variable tidal volumes increase the mean driving pressure. In addition, Jensen’s theorem foresees that, in non‐injured lungs, variability in tidal volumes would only limit derecruitment, given that no convex portion is present on the PV curve [ 19 ]. Fig.…”
Section: Mechanisms Of Variable Ventilationmentioning
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency medicine 2016. Other selected articles can be found online at http://www.biomedcentral.com/collections/annualupdate2016. Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www.springer.com/series/8901.
“…In both conditions, ventilation would mainly occur in the zone of the PV curve where variable tidal volumes increase the mean driving pressure. In addition, Jensen's theorem foresees that, in non-injured lungs, variability in tidal volumes would only limit derecruitment, given that no convex portion is present on the PV curve [19].…”
Section: Recruitment and Stabilization Of Ventilated Lung Regionsmentioning
“…We used saline lavage to deplete surfactant in the rat lung. Saline lung lavage is a widely used rat model to investigate lung injury (8,20). The Pa O 2 /FI O 2 was used as a parameter to monitor the success of the lung injury.…”
Volumetric capnography is a standard method to determine pulmonary dead space. Hereby, measured carbon dioxide (CO2) in exhaled gas volume is analyzed using the single-breath diagram for CO2. Unfortunately, most existing CO2 sensors do not work with the low tidal volumes found in small animals. Therefore, in this study, we developed a new mainstream capnograph designed for the utilization in small animals like rats. The sensor was used for determination of dead space volume in healthy and surfactant-depleted rats (n = 62) during spontaneous breathing (SB) and mechanical ventilation (MV) at three different tidal volumes: 5, 8, and 11 ml/kg. Absolute dead space and wasted ventilation (dead space volume in relation to tidal volume) were determined over a period of 1 h. Dead space increase and reversibility of the increase was investigated during MV with different tidal volumes and during SB. During SB, the dead space volume was 0.21 ± 0.14 ml and increased significantly at MV to 0.39 ± 0.03 ml at a tidal volume of 5 ml/kg and to 0.6 ± 0.08 ml at a tidal volume of 8 and 11 ml/kg. Dead space and wasted ventilation during MV increased with tidal volume. This increase was mostly reversible by switching back to SB. Surfactant depletion had no further influence on the dead space increase during MV, but impaired the reversibility of the dead space increase.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
