Time-dependent modulation of inhibitory avoidance memory by spermidine in rats

Systemic administration of polyaminergic agents modulate fear conditioning in rats

“…In addition, we showed that the modulation of fear conditioning by arcaine is timedependent, as its intraperitoneal administration 0, 60, or 180 min after training impairs fear conditioning. This is in agreement with previous results showing that the effect of intrahippocampal spermidine on memory of inhibitory avoidance is time-dependent (Berlese et al 2005).…”

“…This facilitatory effect of systemically injected spermidine on memory is in agreement with the view that polyamines modulate memory by facilitating NMDA receptor activity (Berlese et al 2005;Guerra et al 2006;Kishi et al 1998a,b;Meyer et al 1998;Mikolajczak et al 2002;Nishiga and Kamei 2003;Rubin et al 2000Rubin et al , 2001Rubin et al , 2004Tadano et al 2004). In fact, it has been demonstrated that intrahippocampus and intra-basolateral amygdala administration of spermidine improves the consolidation of inhibitory avoidance and fear conditioning tasks, respectively (Berlese et al 2005;Guerra et al 2006;Rubin et al 2000Rubin et al , 2001Rubin et al , 2004.…”

“…In fact, it has been demonstrated that intrahippocampus and intra-basolateral amygdala administration of spermidine improves the consolidation of inhibitory avoidance and fear conditioning tasks, respectively (Berlese et al 2005;Guerra et al 2006;Rubin et al 2000Rubin et al , 2001Rubin et al , 2004. In addition, the intracerebroventricular administration of spermidine antagonizes the deficits in working memory induced by 7-chlorokynurenic acid, a NMDA receptor antagonist, in the radial maze (Nishiga and Kamei 2003) and attenuates the memory impairment induced by olfactory bulbectomy in the passive avoidance task (Tadano et al 2004).…”

“…The immediately post-training intrahippocampal and intra-amygdala administration of low doses of spermidine improves memory of the inhibitory avoidance (Rubin et al 2000(Rubin et al , 2001 and fear conditioning tasks (Rubin et al 2004). The facilitatory effect of low doses of spermidine on the memory of the inhibitory avoidance task is restricted to the acquisition and early consolidation phases, as it does not alter late consolidation and retrieval (Berlese et al 2005). It is also remarkable that the facilitatory effects of spermidine are antagonized by minute amounts of arcaine, an antagonist of the NMDA receptor polyamine binding site, suggesting that the NMDA receptor is involved in the memory improvement induced by spermidine (Rubin et al 2000(Rubin et al , 2001(Rubin et al , 2004.…”

Arcaine and MK-801 make recall state-dependent in rats

“…Polyamines have also biphasic effects on learning and memory, since they facilitate the acquisition and/or early consolidation of inhibitory avoidance (Berlese et al 2005;Guerra et al 2006;Rubin et al 2000Rubin et al , 2001, fear conditioning (Camera et al 2007;Rubin et al 2004) and the 14-unit Tmaze (Shimada et al 1994) tasks at low doses, but have no effect at high doses. Interestingly, spermidine has no effect on late consolidation and retrieval (Berlese et al 2005).…”