Arcaine and MK-801 make recall state-dependent in rats

Ceretta, Ana Paula Chiapinotto; Camera, Keli; Mello, Carlos Fernando; Rubin, Maribel Antonello

doi:10.1007/s00213-008-1304-7

Cited by 35 publications

(16 citation statements)

References 29 publications

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“…Given the absence of MK-801 at test, this would have resulted in the observed impairment, consistent with prior reports that MK-801 causes state-dependent retrieval effects (Ceretta et al 2008;Flint et al 2013). However, it is not obvious why the VR20 session, but not the other reactivation procedures, would preferentially induce state-dependent learning.…”

Section: Reactivation-dependent Lever Pressing Impairmentsupporting

confidence: 84%

Reconsolidation of a well-learned instrumental memory

et al. 2014

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Once consolidated, memories are dynamic entities that go through phases of instability in order to be updated with new information, via a process of reconsolidation. The phenomenon of reconsolidation has been demonstrated in a wide variety of experimental paradigms. However, the memories underpinning instrumental behaviors are currently not believed to reconsolidate. We show that well-learned lever pressing in rats does undergo reconsolidation, which can be disrupted by systemic administration of the noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist (+)-5-methyl-10,11-dihydro-SH-dibenzo[a,d]cyclohepten-5,10-imine maleate (MK-801) when administered prior to a switch to a variable, but not fixed, ratio schedule. Disruption of reconsolidation resulted in a reduction in long-term lever pressing performance and diminished the sensitivity of behavior to contingency change. Further investigation demonstrated that expression of the reconsolidation impairment was not affected by outcome value, implying a deficit in a stimulus -response (S -R) process. The ability to disrupt the performance of well-learned instrumental behaviors is potentially of great importance in the development of reconsolidation-based clinical treatments for conditions that involve compulsive seeking behaviors.

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Section: Reactivation-dependent Lever Pressing Impairmentsupporting

confidence: 84%

Reconsolidation of a well-learned instrumental memory

et al. 2014

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“…Since our previous studies showed that pretraining or post-training Darbandi et al 2008) administration of morphine produces amnesia which can be reversed by pre-test administration the same drug, it can be suggested that the role of memory consolidation in the state-dependent learning may be important. Ceretta et al (2008) also reported that state-dependent learning which is induced by posttraining administration of negative modulators of the NMDA receptors, MK-801 and arcaine may be dependent on the effects of the drugs on early consolidation of inhibitory avoidance and memory retrieval.…”

Section: Discussionmentioning

confidence: 96%

Role of the central amygdala GABA-A receptors in morphine state-dependent memory

2010

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“…The concentration of the MK-801 dose has a significant impact on the type of effects. It has been reported that a low dose of MK-801 (0.03 mg/kg) was not enough to disrupt memory formation, but it was able to cause state dependency for the task (Ceretta et al, 2008).…”

Section: Discussionmentioning

confidence: 99%