Time-dependent expression of annexin 1 in a model of chronic granulomatous inflammation

Abstract

The pattern of ANXA1 expression indicates that infiltrated neutrophils are responsible for the majority of ANXA1 present both at early and later stages of this model of granulomatous inflammation.

Annexin 1: Differential expression in tumor and mast cells in human larynx cancer

“…Other studies have also demonstrated difference in ANXA1 expression patterns at mRNA and protein levels. 28,30 This data correlated with the antiproliferative response, suggesting that peptide Ac2-26 can trigger Hep-2 cell growth regulation by direct interaction with the ANXA1 FPR receptor. The peptide may also have activated endogenous ANXA1 expression, resulting in growth regulation by an unclarified autocrine/paracrine mechanism.…”

“…The sections (1 lm thick) were prepared onto histological slides, 28 washed in 0.1 M Tris buffer (Sigma Chemical), pH 8.2, incubated for 30 min with 3% hydrogen peroxide and then washed 3 times in Tris buffer for further 30 min. Nonspecific binding sites were then blocked with 10% Chicken Egg Albumin in Tris buffer (TBAE).…”

Expression of annexin A1 in Leishmania-infected skin and its correlation with histopathological features

“…However, the role of ANXA1 in this response is unknown. Our data demonstrate that skin macrophages from patients with cutaneous leishmaniasis express ANXA1 more abundantly than do macrophages from uninfected skin, major histocompatibility complex those observed in other leukocytes at steady state and during acute (29) or chronic infl ammation (30) . Abundant expression at infection sites also suggests that the protein may be involved in phagocytosis of parasites.…”

“…T cells in cellular lesions express ANXA1 robustly, presumably due to widespread infl ammation, as indicated by accumulation of lymphohistiocytic and plasmacytic infi ltrate, edema, and absence of granuloma. ANXA1 has been described in the literature as a key regulator of T cell activation and migration to infl ammatory sites (29) (30) (33) , and of signaling pathways (p38, ERK MAPK, Akt, and NF-κB) that control production of cytokines such as TNF-α, INF-γ, IL-2, and IL-17 (37) (38) . ANXA1 also regulates the differentiation and proliferation of lymphocytes (18) .…”

Expression of Annexin A1 in Normal and Chronically Inflamed Nasal Mucosa

“…6 Experimental data indicate that annexin A1 is mainly active in models of inflammation where the involvement of neutrophils was crucial to the development of the response, 13 although it is also expressed in eosinophils and mast cells.…”