Time-dependent effect analysis of antipsychotic treatment in a naturalistic cohort study of patients with schizophrenia

Abstract

Unplanned readmissions are very common for patients with schizophrenia but antipsychotic drug treatment is associated with a strong risk-reducing effect in this regard.

Factors Associated with Psychiatric Readmissions: A Systematic Review

“…In one month, readmission rates ranged from 11% to 31% (Boaz et al, 2013;Byrne, Hooke, & Page, 2010, Kroken, Mellesdal, Wentzel-Larsen, Jørgensen & Johnsen, 2012Sánchez, Jaramillo & Herazo, 2013;Zilber, Hornik-Lurie & Lerner, 2011). In three months, there were 49% of readmissions (Sánchez et al, 2013), while in six months, rates varied between 21% and 37% (Byrne et al, 2010;Kroken et al, 2012;et al, 2014;Pfiffner et al, 2014).…”

“…In three months, there were 49% of readmissions (Sánchez et al, 2013), while in six months, rates varied between 21% and 37% (Byrne et al, 2010;Kroken et al, 2012;et al, 2014;Pfiffner et al, 2014). The most studied period for readmission rates was one year (n = 13) with rates varying between 10% and 72% (Boaz et al, 2013;Castro, Furegato, & Santos, 2010;Jaramillo-Gonzalez, Sanchez-Pedraza, & Herazo, 2014;Kikuchi, Abo, Kumakura, Kubota, & Nagano, 2013;Kroken et al, 2012;Loch, 2012;Martínez-Ortega et al, 2012;Schmutte, Dunn, & Sledge, 2010;Zhang, Harvey, & Andrew, 2011).…”

“…The main results are shown in Table 1. (Sánchez et al, 2013) 3 months 49.5% (Sánchez et al, 2013) 6 months 15.3% (Byrne et al, 2010); 21% (Moss et al, 2014); 31.2% (Kroken et al, 2012) 1 year 10% (Martínez-Ortega et al, 2012); 20.5% (Kikuchi et al, 2013); 30% (Schmutte et al, 2010); 34% (Castro et al, 2010); 42.6% (Loch, 2012); 44.8% (Kroken et al, 2012); 46% (Zhang et al, 2011); 60% (Jaramillo-Gonzalez et al, 2014); 72% (Boaz et al, 2013) 2 years 79.8% (Bowersox et al, 2012); 84% (Boaz et al 2013) 3 years 55.6% (Kroken et al, 2012) 7 years 27.6% (Batalla et al, 2013).…”

“…A study comparing the time to readmission between users with multiple diagnoses and users with a first episode of depression found that 15% and 17.6% of users presented, respectively, at least one hospitalization in two years (Byrne et al, 2010). In a study using the three-year criterion, 55.6% of the participants were readmitted (Kroken et al, 2012).…”

Time to discontinuation of antipsychotic drugs in a schizophrenia cohort: influence of current treatment strategies

“…Accordingly, to study the effectiveness of antipsychotic treatment in a representative clinical setting we performed an open cohort study of all patients discharged from hospital during a 5-year period and recorded antipsychotic treatment and concomitant psychosocial treatment (including involuntary treatment) in a time-dependent manner. Using this cohort, we have recently demonstrated the strong preventive effect of antipsychotic treatment on readmissions for patients with schizophrenia [Kroken et al 2012].…”