Time-dependent degradation of titanium osteoconductivity: An implication of biological aging of implant materials

Att, Wael; Hori, Norio; Takeuchi, Masato; Ouyang, Jianyong; Yang, Yang; Anpo, Masakazu; Ogawa, Takahiro

doi:10.1016/j.biomaterials.2009.06.040

Cited by 240 publications

(264 citation statements)

References 41 publications

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“…A series of studies revealed that osteoblast-affinity to titanium implants decreases over time. Furthermore, an implant biomechanical test demonstrated that the biomechanical strength of the bone-titanium integration for 4-week-old implants was less than half that for newly processed implants during the early healing stage at week 2 9,22) . This "aging-like change" of the biological potential of titanium may be one of the reasons why the currently used titanium implants never achieve the ideal complete osseointegration.…”

Section: Discussionmentioning

confidence: 99%

“…It has been generally accepted that the incomplete achievement level of osseointegration (45-65% of bone-implant contact on average) is the utmost limit of currently available implants 6,7) . A series of studies revealed that these unfavorable bone-implant contacts were attributed to age-related impaired bioactivity of the implants, defined as the biological aging of titanium [8][9][10] . This phenomenon is caused by the loss of hydrophilicity and inevitable occurrence of progressive contamination of the titanium surfaces by hydrocarbons.…”

Section: Introductionmentioning

confidence: 99%

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NaOCl-mediated biofunctionalization enhances bone-titanium integration

et al. 2015

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The aim of this study was to examine the effect of NaOCl pretreatment on the biomechanical fixation of implant at the early healing stage of a rat model. Polished titanium cylindrical implants and disks were prepared, and one-half of these samples were dual acidetched. Then, one-half of both surfaces were chemically-cleaned by pretreatment with 5% NaOCl solution for 24 h. Morphological analyses showed that there was no significant difference between before and after NaOCl treatment. The wettability measurement demonstrated that NaOCl treatment secondarily converted both titanium surfaces from hydrophobic to superhydrophilic, accompanied by the removal of hydrocarbons from the titanium surfaces. Biomechanical push-in test indicated that the bone-titanium integration strength of the NaOCl-treated implants were significantly greater than that of the untreated implants (p<0.05). These results showed that NaOCl pretreatment enhanced the osseointegration capability of titanium, indicating its potential for a simple chemical chair-side pretreatment method.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

NaOCl-mediated biofunctionalization enhances bone-titanium integration

et al. 2015

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“…A number of reports have revealed that cell attachment is promoted on superhydrophilic surfaces rather than on hydrophobic surfaces 14,28,29) . In the present study, there are several possible explanations for the mechanism of increasing the cell attachment capability in the O2-plasma specimen: decreased hydrocarbons, formation of basic hydroxyl groups, and increasing polar components.…”

Section: Discussionmentioning

confidence: 99%

“…In general, Ti preserved in air adsorbs hydrocarbon, and its surface becomes hydrophobic over time 29) . UV light-induced superhydrophilicity of TiO2 was discovered in 1997 30) .…”

Section: Discussionmentioning

confidence: 99%

Influence of plasma and ultraviolet treatment of zirconia on initial attachment of human oral keratinocytes: Expressions of laminin γ2 and integrin β4

et al. 2014

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Initial attachment of human oral keratinocytes cultured on yttria-stabilized tetragonal zirconia polycrystal (TZP) surfaces that were subjected to UV or oxygen plasma (O2-plasma) treatment was investigated. The viability of the attached cells, mRNA expression of laminin γ2 and integrin β4, distribution of laminin γ2 and integrin β4, cell area, and cell morphology were assessed. The results showed that no differences in the viability of attached cells were recognized among the conditions. However, expression of laminin γ2 and integrin β4 as well as cell morphology were promoted only in O2-plasma specimens even though superhydrophilicity was obtained in both the UV and O2-plasma specimens compared with the untreated control specimen. The photocatalytic activity was believed to be closely involved in the above-mentioned differences. The results of this study suggest that TZP surface treated with oxygen plasma promotes the initial attachment capability of human oral keratinocytes with enhancing the extracellular matrix such as laminin γ2.

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“…In addition, there is still room for improvement in the ratio of the titanium surface area that is in close contact with the bone, which is currently 45-65 % 13,14) . In the titanium implants now used in implant treatment, cell adhesion, proliferation, and differentiation decrease over time due to adhesion of carbon compounds to the titanium surface 15,16) . Ozone is used in various fields such as medicine, industry, and dairy farming for sterilization, deodorization, and bleaching 17) as well as in many areas of dentistry.…”

Section: Introductionmentioning

confidence: 99%

Effect on Osteogenesis of Cleaning Titanium Implants with Ozonated Water

Yoshida

Ando

Sugita

et al. 2016

J. Hard Tissue Biology.

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Carbon compounds accumulate over time on titanium surfaces. This is reported to reduce osseointegration of titanium implants in bone. Ozonated water was found to remove carbon compounds and to have a sufficient cleaning effect. The effects of the ozonated water on the titanium surface were evaluated by cell culture and mechanical tests. In vitro study, titanium disks (diameter 20 mm, thickness 1 mm, Grade 2) were treated with sulfuric acid. Disks in the control group were surface cleaned with distilled water, and disks in the O 3 group were surface cleaned for 10 min with ozonated water. The experimental animals were male Sprague-Dawley (SD) rats. We tested for cell proliferation activity, alkaline phosphatase (ALP) activity, calcification and measured calcium concentrations. In vivo study, titanium implants (diameter 1 mm, length 2 mm, Grade 2) were treated with sulfuric acid. Control group samples were washed for 10 min with distilled water immediately before implantation. O 3 group samples were washed for 10 min with ozonated water. We performed push-in testing using a mechanical testing machine. The femurs were removed at 2 and 4 weeks after implantation. Cell proliferation activity was higher in the O 3 group than in the control group at 24 h after cell seeding. Similarly, ALP activity was higher in the O 3 group than in the control group, indicating higher cell differentiation potential. Cell calcification was higher in the O 3 group than in the control group at all measurement times. Maximum compressive stress was significantly higher in the O 3 group compared with the control group at 2 weeks after implantation (p < 0.05). At 4 weeks after implantation, no difference was found between the groups. Osseointegration time was decreased by cleaning titanium implants with ozonated water.

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Time-dependent degradation of titanium osteoconductivity: An implication of biological aging of implant materials

Cited by 240 publications

References 41 publications

NaOCl-mediated biofunctionalization enhances bone-titanium integration

NaOCl-mediated biofunctionalization enhances bone-titanium integration

Influence of plasma and ultraviolet treatment of zirconia on initial attachment of human oral keratinocytes: Expressions of laminin γ2 and integrin β4

Effect on Osteogenesis of Cleaning Titanium Implants with Ozonated Water

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