Time-dependent changes of myeloperoxidase in relation to in-hospital mortality in patients with the first anterior ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention

Stanković, Sanja; Ašanin, Milika; Trifunović, D.; Majkić-Singh, Nada; Ignjatović, Svetlana; Mrdović, Igor; Matić, Dragan; Savić, Lidija; Marinković, Jelena; Ostojić, Miodrag; Vasiljević, Zorana

doi:10.1016/j.clinbiochem.2012.02.015

Cited by 13 publications

(14 citation statements)

References 42 publications

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“…MPO concentrations appeared to be reliably stable in ethylenediaminetetraacetic acid (EDTA) plasma . Time dependent changes of MPO serum concentration were also shown after primary percutaneous coronary intervention (PCI) in patients with MI presenting anterior ST‐segment elevation . However, so far there exists no standardized laboratory MPO test pattern for routine clinical use.…”

Section: Introductionmentioning

confidence: 99%

“…21 Time dependent changes of MPO serum concentration were also shown after primary percutaneous coronary intervention (PCI) in patients with MI presenting anterior ST-segment elevation. 22 However, so far there exists no standardized laboratory MPO test pattern for routine clinical use. Risk scores and clinically used biomarkers were proven to predict mortality among patients with suspected ACS.…”

Section: Introductionmentioning

confidence: 99%

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Sequential Analysis of Myeloperoxidase for Prediction of Adverse Events After Suspected Acute Coronary Ischemia

Koch

Henrich

Heidt³

2014

Clinical Cardiology

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Background: Myeloperoxidase (MPO) plasma values predict major adverse cardiac events (MACE) in cases of acute coronary syndrome. The effect of serial testing in patients who are suspected for acute coronary ischemia is unclear. Hypothesis: We hypothesize that sequential MPO measurement may improve prediction of MACE in patients with suspected acute coronary ischemia. Methods: The present prospective observational study examined the prognostic significance of MPO in 917 patients with suspicion of acute coronary syndrome. Blood samples were taken at cardiac catheter laboratory admission and the day after coronary angiography. We recorded patients' mortality, the occurrence of cardiac ischemia, and repeated percutaneous coronary intervention through the next 6 months. Results: Mortality among patients with increased MPO plasma levels the day after coronary angiography was increased significantly (P < 0.01). Patients with MPO values above 306.3 pmol/L had a significantly higher incidence of 6-month MACE (P < 0.0001) than patients with lower plasma values. Cox proportional hazards multivariate regression analyses revealed that MPO was an independent marker for MACE after suspected acute coronary ischemia (P = 0.048). However, MPO plasma levels at cardiac catheter laboratory admission showed no prognostic significance. Conclusions: In patients with suspected myocardial infarction, MPO levels above 306.3 pmol/L measured 24 hours after onset of symptoms were independent predictors of 6-month mortality and MACE.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sequential Analysis of Myeloperoxidase for Prediction of Adverse Events After Suspected Acute Coronary Ischemia

Koch

Henrich

Heidt³

2014

Clinical Cardiology

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“…Myeolperoxidase is stored in and released by activated neutrophilic granulocytes in inflammatory conditions. Elevated levels can be found in patients with, myocardial or endothelial damage [22,23], and in inflammatory and infectious diseases such as sepsis, brucellosis and HIV [24-26]. Very high levels were found in the malaria group, reflecting vascular damage and inflammation.…”

Section: Discussionmentioning

confidence: 99%

Clinical relevance of different biomarkers in imported plasmodium falciparum malaria in adults: a case control study

Stauga

Hahn

Brattig

et al. 2013

Malar J

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BackgroundFor rapid initiation of anti-malarial treatment and prevention of complications, early diagnosis and risk stratification is important in patients with Plasmodium falciparum malaria. Routine laboratory values do not correlate well with disease severity. The aim of this study was to determine the diagnostic and prognostic value of several biomarkers related to inflammation; endothelial and cardiac dysfunction; coagulation, and haemolysis in imported P. falciparum malaria.MethodsIn a prospective case-control study, 79 adult travellers with both uncomplicated and complicated P. falciparum malaria were included between 2007 and 2011. Forty-one healthy subjects were included as controls. Blood samples were obtained within 24 hours after first consultation to assess routine laboratory values as well as markers related to inflammation (PAPP-A, copeptin, CRP), endothelial activation (MPO, elastase-2, endothelin-1, sICAM-1, sVCAM-1), cardiac function (NT-proBNP, MR-proANP), coagulation (fibrinogen, D-dimers, platelet count), and haemolysis (LDH). Prognostic performance was assessed using the receiver operating characteristic curve (area under the curve = AUROC).ResultsTwelve (15.2%) patients had severe P. falciparum malaria. In the patient group, significant thrombocytopaenia was found, all other markers but PAPP-A were significantly elevated. Diagnostic performance was best for CRP with an AUROC of 1.00, followed by MPO (0.99), D-dimers (0.98), elastase-2 (0.98), and sICAM-1 (0.98). Biomarker levels did not correlate well with disease severity.ConclusionThe combination of travel history, fever prior to blood sampling, and CRP serum levels above or below 10.8 mg/l upon hospital admission, best discriminated between malaria patients and control persons. None of the biomarkers studied predicted the presence or the development of malaria complications, neither at the time of admission, nor during hospitalization.

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“…The plasma MPO level independently predicts in-hospital mortality in patients with STEMI treated by PCI (Table 3). 63…”

Section: Biomarkers Of Plaque Instabilitymentioning

confidence: 99%

Emerging families of biomarkers for coronary artery disease: inflammatory mediators

Yayan¹

2013

VHRM

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IntroductionInflammation has been implicated in the development of atherosclerosis in patients with acute coronary syndrome. C-reactive protein is an established nonspecific prognostic inflammatory biomarker for patients with acute coronary syndrome in the medical literature. This has led to a concerted effort to identify circulating inflammatory biomarkers to facilitate predicting the risk for and diagnosing coronary artery disease in at-risk subjects. The objective of this study was to search after novel inflammatory biomarkers reported as useful for diagnosing coronary artery disease.MethodsThe PubMed database was searched for reports published from January 1, 2000 to June 30, 2012 of novel circulating biomarkers for coronary artery disease in addition to the established biomarker, C-reactive protein. The search terms used were “infarction”, “biomarkers”, and “markers”, and only original articles describing clinical trials that were written in English were included. All published articles were separately examined carefully after novel inflammatory markers for acute coronary syndrome. All irrelevant publications without content pertaining to inflammatory biomarkers for acute coronary syndrome were excluded from this study. Our results reflect all articles concerning biomarkers in humans.ResultsThe PubMed search yielded 4,415 research articles. After further analysis, all relevant published original articles examining 53 biomarkers were included in this review, which identified 46 inflammation biomarkers useful for detecting coronary artery disease.ConclusionThe emergence of diverse novel biomarkers for coronary artery disease has provided insight into the varied pathophysiology of this disease. Inflammatory biomarkers have tremendous potential in aiding the prediction of acute coronary syndrome and recurrent ischemic episodes, and will eventually help improve patient care and management.

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Time-dependent changes of myeloperoxidase in relation to in-hospital mortality in patients with the first anterior ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention

Cited by 13 publications

References 42 publications

Sequential Analysis of Myeloperoxidase for Prediction of Adverse Events After Suspected Acute Coronary Ischemia

Sequential Analysis of Myeloperoxidase for Prediction of Adverse Events After Suspected Acute Coronary Ischemia

Clinical relevance of different biomarkers in imported plasmodium falciparum malaria in adults: a case control study

Emerging families of biomarkers for coronary artery disease: inflammatory mediators

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