Time-Dependent Association Between Metabolic Syndrome and Risk of CKD in Korean Men Without Hypertension or Diabetes

Ryu, Seungho; Chang, Yoosoo; Woo, Hee‐Yeon; Lee, Kyu‐Beck; Kim, Soo-Geun; Kim, Dong Il; Kim, Won Sool; Suh, Byung-Seong; Jeong, Cheol‐Ho; Yoon, Kyungho

doi:10.1053/j.ajkd.2008.07.027

Cited by 76 publications

(76 citation statements)

References 44 publications

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“…Because increased HOMA-IR is emerging as an independent risk factor for the development of CKD in adults (30), there is also potential for insulin resistance to emerge as a risk factor for progression among children with pre-existing CKD. Longitudinal follow-up is needed to elucidate whether abnormal glucose metabolism is persistent and its role in the development of CVD and progression of CKD.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Correlates of Multiple Cardiovascular Risk Factors in Children with Chronic Kidney Disease

Wilson

Schneider

Cox

et al. 2011

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives Although prevalence of traditional cardiovascular risk factors (CVRF) has been described in children with CKD, the frequency with which these CVRF occur concomitantly and the clinical characteristics associated with multiple CVRF are unknown. This study determined the prevalence and characteristics of multiple CVRF in children in the Chronic Kidney Disease in Children study.Design, setting, participants, & measurements Using cross-sectional data from first follow-up visits, we determined the prevalence of four CVRF: hypertension (casual BP Ͼ95 th percentile or self-reported hypertension with concurrent use of anti-hypertensive medication), dyslipidemia (triglycerides Ͼ130 mg/dl, HDL Ͻ40 mg/dl, non-HDL Ͼ160 mg/dl, or use of lipid-lowering medication), obesity (BMI Ͼ95 th percentile), and abnormal glucose metabolism (fasting glucose Ͼ110 mg/dl, insulin Ͼ20 IU/ml, or HOMA-IR Ͼ2.20, Ͼ3.61, or Ͼ3.64 for those at Tanner stage 1, 2 to 3, or 4 to 5, respectively) in 250 children (median age 12.2 years, 74% Caucasian, median iohexol-based GFR 45.2 ml/min per 1.73 m 2 ).Results Forty-six percent had hypertension, 44% had dyslipidemia, 15% were obese, and 21% had abnormal glucose metabolism. Thirty-nine percent, 22%, and 13% had one, two, and three or more CVRF, respectively. In multivariate ordinal logistic regression analysis, glomerular disease and nephrotic-range proteinuria were associated with 1.96 (95% confidence interval, 1.04 to 3.72) and 2.04 (95% confidence interval, 0.94 to 4.43) higher odds of having more CVRF, respectively. ConclusionsWe found high prevalence of multiple CVRF in children with mild to moderate CKD. Children with glomerular disease may be at higher risk for future cardiovascular events.

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Section: Discussionmentioning

confidence: 99%

Prevalence and Correlates of Multiple Cardiovascular Risk Factors in Children with Chronic Kidney Disease

Wilson

Schneider

Cox

et al. 2011

Clinical Journal of the American Society of Nephrology

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“…The sample size of included studies ranged from 176 to 17039 patients with MetS. Three studies included United States or European populations (10 -12), whereas eight studies included Asian populations (13,14,(21)(22)(23)(24)(25)(26). Follow-up duration ranged from 3.5 to 12 years.…”

Section: Statistical Analysesmentioning

confidence: 99%

“…Nine studies excluded participants with diabetes (10 -12,14,22-26). Five studies used the modified NCEP-ATP III criteria for diagnosis of MetS (14,21,22,25,26); three studies used the NCEP-ATP III criteria (10,12,23); two studies examined both the modified NCEP-ATP III and IDF definitions (11,24); and one study classified patients as having MetS on the basis of modified NCEP-ATP III, NCEP-ATP III, and IDF definitions (13). For studies in Asian populations that reported more than one definition, we selected outcomes using the modified NCEP-ATP III criteria for this analysis.…”

Section: Statistical Analysesmentioning

confidence: 99%

“…For studies in Asian populations that reported more than one definition, we selected outcomes using the modified NCEP-ATP III criteria for this analysis. Three studies used body mass index (BMI) Ն25 kg/m 2 instead of waist circumference to assess obesity (14,25,26) because of a lack of data. Only four studies reported the use of creatinine calibration (10,13,14,25).…”

Section: Statistical Analysesmentioning

confidence: 99%

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Metabolic Syndrome and Kidney Disease

Thomas

Sehgal

Kashyap

et al. 2011

Clinical Journal of the American Society of Nephrology

468

322

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SummaryBackground and objectives Observational studies have reported an association between metabolic syndrome (MetS) and microalbuminuria or proteinuria and chronic kidney disease (CKD) with varying risk estimates. We aimed to systematically review the association between MetS, its components, and development of microalbuminuria or proteinuria and CKD.Design, setting, participants and measurements and population We searched MEDLINE (1966 to October 2010), SCOPUS, and the Web of Science for prospective cohort confidence interval (CI) studies that reported the development of microalbuminuria or proteinuria and/or CKD in participants with MetS. Risk estimates for eGFR Ͻ60 ml/min per 1.73 m 2 were extracted from individual studies and pooled using a random effects model. The results for proteinuria outcomes were not pooled because of the small number of studies.Results Eleven studies (n ϭ 30,146) were included. MetS was significantly associated with the development of eGFR Ͻ60 ml/min per 1.73 m 2 (odds ratio, 1.55; 95% CI, 1.34, 1.80). The strength of this association seemed to increase as the number of components of MetS increased (trend P value ϭ 0.02). In patients with MetS, the odds ratios (95% CI) for development of eGFR Ͻ60 ml/min per 1.73 m 2 for individual components of MetS were: elevated blood pressure 1

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“…16,22 There was evidence that it showed a strong link between renal damage and MetS criteria. 23 However, above studies did not predict the effect of treating MetS. We discussed that controlled MetS in early-stage CKD appeared to decrease the risk of late-stage CKD, but it seemed that the renal function decline in our selected population (estimated annual GFR decline 7.4 mL/min/1.73 m 2 in CMS group and 16.8 mL/min/1.73 m 2 in UMS group) conferred faster progression to late-stage CKD as compared to another study (0 mL/min/1.73 m 2 in CMS group and 5 mL/min/1.73 m 2 UMS group).…”

Section: Discussionmentioning

confidence: 99%

Association between management of metabolic syndrome and progression of early-stage chronic kidney disease: an observational cohort study

Lin

Huang

et al. 2014

Renal Failure

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Time-Dependent Association Between Metabolic Syndrome and Risk of CKD in Korean Men Without Hypertension or Diabetes

Cited by 76 publications

References 44 publications

Prevalence and Correlates of Multiple Cardiovascular Risk Factors in Children with Chronic Kidney Disease

Prevalence and Correlates of Multiple Cardiovascular Risk Factors in Children with Chronic Kidney Disease

Metabolic Syndrome and Kidney Disease

Association between management of metabolic syndrome and progression of early-stage chronic kidney disease: an observational cohort study

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