Association between management of metabolic syndrome and progression of early-stage chronic kidney disease: an observational cohort study

Lin, Jui-Hsiang; Wu, Hung-Chieh; Huang, Wen‐Hung; Lu, Chien-Lu; Cheng, Mei-Hua; Wang, Han-Ting; Yen, Tzung‐Hai; Wang, Weijie

doi:10.3109/0886022x.2014.964140

Cited by 7 publications

(8 citation statements)

References 27 publications

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“…[8][9][10] Our study can explain the difference in these results by investigating early renal function decline (eGFR 60-90 mL/min/1.73 m 2 ) rather than chronic renal failure. 26) Yu et al 27) suggested that obesity phenotypes do not significantly contribute to mildly reduced eGFR. Instead, sex, aging, dyslipidemia, and hyperglycemia were associated with an increased risk of mildly In a retrospective observational cohort study conducted in Taiwan, metabolic components were positively associated with renal function deterioration, and treatment of metabolic syndrome was shown to attenuate CKD progression in patients with early-stage CKD.…”

Section: Discussionmentioning

confidence: 99%

The Association between Obesity Phenotypes and Early Renal Function Decline in Adults without Hypertension, Dyslipidemia, and Diabetes

et al. 2019

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Background: The prevalence of chronic kidney disease is increasing worldwide. Several studies have suggested that obesity is associated with early renal dysfunction. However, little is known about the relationship between obesity phenotypes and early renal function decline. Therefore, this study aimed to identify the relationship between obesity phenotypes and early renal function decline in adults without hypertension, dyslipidemia, and diabetes. Methods: We conducted a cross-sectional analysis of clinical and anthropometric data from 1,219 patients who underwent a routine health checkup in 2014. We excluded adults with cardiovascular disease, renal disease, diabetes, hypertension, dyslipidemia, or low glomerular filtration rate (<60 mL/min/1.73 m 2). Renal function was determined according to the estimated glomerular filtration rate calculated using the Chronic Kidney Disease Epidemiology Collaboration creatinine-cystatin C equation. Results: Age, sex, body mass index, waist circumference, triglyceride, low-density lipoprotein, and fasting glucose had an association with the estimated glomerular filtration rate. After adjusting for age, sex, smoking status, and alcohol intake, the odds ratios of the metabolically abnormal normal weight and metabolically abnormal obese phenotypes for the presence of low estimated glomerular filtration rates were 1.807 (95% confidence interval, 1.009-3.236) and 1.834 (95% confidence interval, 1.162-2.895), compared with the metabolically healthy normal weight phenotype. However, the metabolically healthy obese phenotype did not show a significant association with early renal function decline. Conclusion: In this cross-sectional study, we confirmed the association between the metabolically abnormal normal weight and metabolically abnormal obese phenotypes and early kidney function decline in adults without hypertension, dyslipidemia, and diabetes.

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Section: Discussionmentioning

confidence: 99%

The Association between Obesity Phenotypes and Early Renal Function Decline in Adults without Hypertension, Dyslipidemia, and Diabetes

et al. 2019

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“…The elevated blood pressure and impaired fasting glucose were the main risk factors for CKD among the single components of the syndrome, proposing that, independent of the presence of MetS, individuals with both hypertension and diabetes require a special attention for CKD screening. Since the prevalence of diabetes, hypertension, metabolic syndrome and CKD are rising worldwide, and both metabolic syndrome and CKD increase the risk of progression to end‐stage renal disease and cardiovascular disorders, these findings have significant clinical and public health implications. Therefore, early detection, management and eventually prevention of the metabolic syndrome and its individual components should become an important approach for the reduction of CKD burden in diabetic, in non‐diabetic and in the general population.…”

Section: Discussionmentioning

confidence: 99%

“…The elevated blood pressure and impaired fasting glucose were the main risk factors for CKD among the single components of the syndrome, proposing that, independent of the presence of MetS, individuals with both hypertension and diabetes require a special attention for CKD screening. Since the prevalence of diabetes, hypertension, metabolic syndrome and CKD are rising worldwide, 96-100 and both metabolic syndrome and CKD increase the risk of progression to end-stage renal disease [101][102][103] and cardiovascular disorders, 104,105 these findings have significant clinical and public health implications.…”

Section: Discussionmentioning

confidence: 99%

Metabolic syndrome and its components are associated with increased chronic kidney disease risk: Evidence from a meta-analysis on 11 109 003 participants from 66 studies

et al. 2018

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“…6,[8][9][10] Most reports recognized an independent association between MetS and CKD. 11,12 However, controversies still remain regarding the relationship between decreased estimated glomerular filtration rate (eGFR560 mL/min/1.73 2 ) and individual factors in MetS. Some researchers reported that obesity indicated by elevated body mass index (BMI) which can induce renal injury 13 is an independent culprit in CKD, 14,15 while others observed a U-shaped association between weight change categories and development of CKD.…”

Section: Introductionmentioning

confidence: 99%

Metabolic syndrome does not always play a critical role in decreased GFR

Cai

Wang

et al. 2016

Renal Failure

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Background There is a paucity of literature available as to the relationship between different levels of each metabolic syndrome (MetS) component and decreased GFR. In the present study, we aimed to demonstrate whether MetS always plays a critical role in decreased GFR. Methods A crosssectional study was conducted between February 2010 and September 2012, with 75,468 adults enrolled undergoing measurements of blood pressure as well as tests of blood and urine samples. Univariate and multivariable logistic regression analyses were performed to estimate the odds ratio (OR) with 95% confidence intervals (CI), and the chi-square test was used for categorical variables and described as a percentage. Results Of the 75,468 participants, 350 (0.5%) subjects met criteria for the decreased GFR, with a mean age of 48.79 ± 13.76 years. After adjustment for age, diastolic blood pressure and high-density lipoprotein were inversely related to decreased estimated glomerular filtration rate (eGFR) in multivariable analyses, with an OR (95% CI) of 0.57 (0.39-0.84) and 0.41 (0.24-0.72), respectively. The prevalence rate of CKD in critical group was 0.73% (154 of 21,127) and 0% (0 of 370) in noncritical group. In analysis stratified by the type of MetS components, the differences in noncritical group and the reference group were not statistically significant ( 2 ¼ 1.349, p40.05). Conclusions MetS does not always play a critical role in decreased GFR, with different levels of individual components of MetS exerting idiosyncratic effects in decreased eGFR. In fact, patients with abnormal body mass index, high triglycerides, and elevated fasting plasma glucose would not have impact on decreased GFR.

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Association between management of metabolic syndrome and progression of early-stage chronic kidney disease: an observational cohort study

Cited by 7 publications

References 27 publications

The Association between Obesity Phenotypes and Early Renal Function Decline in Adults without Hypertension, Dyslipidemia, and Diabetes

The Association between Obesity Phenotypes and Early Renal Function Decline in Adults without Hypertension, Dyslipidemia, and Diabetes

Metabolic syndrome and its components are associated with increased chronic kidney disease risk: Evidence from a meta-analysis on 11 109 003 participants from 66 studies

Metabolic syndrome does not always play a critical role in decreased GFR

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