The Association between Obesity Phenotypes and Early Renal Function Decline in Adults without Hypertension, Dyslipidemia, and Diabetes

Choi, Jung In; Cho, Young Hye; Lee, Sang Yeoup; Jeong, Dong Wook; Lee, Jeong Gyu; Yi, Yu Hyeon; Tak, Young Jin; Lee, Seung Hun; Hwang, Hye Rim; Park, Eun Ju

doi:10.4082/kjfm.18.0139

Cited by 10 publications

(10 citation statements)

References 32 publications

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“…Meanwhile, in 135 of first-degree relatives, higher frequency of obesity was noted, followed by overweight and normal weight. Several previous studies have reported similar findings, that increased BMI was independent risk factor for CKDs in general population, diabetes and hypertension (25,26,27,28,29). Indeed, obesity is known to affect hemodynamic, insulin resistance, adipokines changes, low grade inflammation, oxidative stress and endothelial dysfunction, therefore has been suggested to be a risk factor of CKDs.…”

Section: Discussionsupporting

confidence: 54%

Obese First degree relatives of hemodialysis patients are at Higher Risk for Developing Kidney Diseases: In a Cross-sectional Study

Elemam

2019

SJMS

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Background: Previously, it has been demonstrated that obesity is one of the strongest risk factors for incident chronic kidney diseases (CKDs). Currently, we examine the association between Body mass index (BMI) and CKD in first degree relatives (FDRs) of renal failure patients on hemodialysis. Materials and methods: In a cross-sectional study, 135 FDRs of end-stage renal disease (ESRD) patients on hemodialysis were included. Serum creatinine, uric acid, calcium, phosphate, and alkaline phosphatase were measured. Glomerular filtration rate (e-GFR) and albumin to creatinine ratio (ACR) were estimated. The height in Cm, weight in Kg was measured, and the BMI was calculated. Results: Females 64% were found to have a higher frequency than males 36%. The frequency of BMI categories was found to be 26.7% obese, 26.7% overweight, and 46.6. % normal weight. The mean BMI was (26.0 ± 6.62). The prevalence of CKDs is 19.3% among relatives. CKDs were more frequent 42.3 % in obese, followed by 30.8 % in overweight and 26.9% in normal-weight relatives. Obese and overweight relatives have significantly higher ACR than normal weight (P= 0.012). GFR found to be significantly higher in obese and overweight relatives than normal weight (P = 0.000). GFR was negatively correlated with BMI (R = - 0.430, P = 0.000). Conclusion: Obese and overweight RF relatives had higher ACR and lower eGFR. Therefore, obese and overweight members are at higher risk of developing CKD. Keywords: CKDs, Family members, BMI, Obesity, ACR, eGFR. Corresponding author: Abozaid Mohammed Hamid, email: elemam69@hotmail.com

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Section: Discussionsupporting

confidence: 54%

Obese First degree relatives of hemodialysis patients are at Higher Risk for Developing Kidney Diseases: In a Cross-sectional Study

Elemam

2019

SJMS

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“…In the only meta-analysis on MetS in AUD patients none of the five studies analyzed the role of kidney disease in the syndrome 13 . Besides, some other studies in different populations at risk of MetS included the alcohol consumption as a covariate but they did not analyze the association of eGFR and MetS 28 – 30 .…”

Section: Discussionmentioning

confidence: 99%

Prevalence and associations of metabolic syndrome in patients with alcohol use disorder

Hernández-Rubio

Sanvisens

Bolao

et al. 2022

Sci Rep

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Excessive alcohol consumption has been associated with different components of the metabolic syndrome (MetS) such as arterial hypertension, dyslipidemia, type 2 diabetes or obesity. We aimed to analyze the prevalence and associations of MetS in patients with Alcohol Use Disorder (AUD). Cross-sectional study in heavy drinkers admitted for the treatment of AUD between 2013 and 2017. Medical comorbidity, anthropometric data, alcohol use and biological parameters were obtained. MetS was established according to the harmonized definition. A total of 728 patients (22% women) were included; median age was 47 years (IQR: 40–53.5), median alcohol consumption was 160 g/day (IQR: 115–240) and prevalence of MetS was 13.9%. The multivariate analysis showed a significant dose–response effect of estimated glomerular filtration (eGFR) and MetS: relative to patients with eGFR > 90 mL/min, those with eGFR (60–90 mL/min) and those with eGFR < 60 mL/min were 1.93 times (95% CI 1.18–3.15) and 5.61 times (95% CI 1.66–19.0) more likely to have MetS, respectively. MetS was significantly associated with hyperuricemia (OR 2.28, 95% CI 1.36–3.82) and elevated serum GGT (OR 3.67, 95% CI 1.80–7.46). Furthermore, for every increase of 1 year in age, the probability of MetS increased significantly (OR 1.03, 95% CI 1.01–1.05). MetS in heavy drinkers is independently associated with reduced kidney function and metabolic risk factors including hyperuricemia and elevated serum GGT.

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“…One can observe increase renal sodium reabsorption, besides the recruitment of functional reserve with glomerular hyper ltration. Obesity can also promote hypo ltration, increasing the risk for CKD [10][11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Does bariatric surgery improves kidney function? A cohort study

Bezerra

Brandt

Borborema

et al. 2021

Preprint

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Background Obesity is a global epidemic that may cause renal dysfunction. Weight loss in the postoperative follow-up of bariatric surgery may improve renal function in these patients. Thus, the purpose of this study was to give insight on the subject using a sensible biomarker (cystatin C). Methods This cohort was performed in the Obesity Department from Campina Grande – Paraiba, Brazil. It was randomly enrolled 35 obese who underwent bariatric surgery (12 bypass and 23 sleeve) with follow-up of at least one year. The ages ranged from 24 and 57 years. Those with thyroid disease and with renal disease, with microalbuminuria ≥ 30mg/dL, were excluded. Serum levels of creatinine and cystatin C were measured, and the glomerular filtration rate (GFR) was estimated using the CKD Epi (chronic kidney disease epidemiology collaboration) cystatin-creatinine equation. The investigation was approved by the Ethics Committee. Results Twenty five women (71.4%) and 10 men (28.5%) were randomly recruited for the research. The most frequent associated morbidities were: sexual dysfunction (n = 17–48.5%); blood hypertension (n = 15–42.8%); type II diabetes (n = 13–37.1%); anxiety (n = 14–40.0%); and depression (n = 12–34.2%). Twenty three (65.7%) patients underwent sleeve technique and 12 (34.2%) bypass surgery. It was observed a significant reduction of BMI in the post-operative follow-up – p < 0.0001. There was a significant improvement of glomerular filtration rates (p = 0.0091). The improvement of renal function was more significant among those who underwent sleeve surgery as compared to bypass (p = 0.0008). Conclusion It was observed improvement of the majority of morbidities after bariatric surgery, as well as renal function, in obese individuals. Despite these results, larger and longer term outcome cohorts are required for better answer of the main purpose of this health issue.

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The Association between Obesity Phenotypes and Early Renal Function Decline in Adults without Hypertension, Dyslipidemia, and Diabetes

Cited by 10 publications

References 32 publications

Obese First degree relatives of hemodialysis patients are at Higher Risk for Developing Kidney Diseases: In a Cross-sectional Study

Obese First degree relatives of hemodialysis patients are at Higher Risk for Developing Kidney Diseases: In a Cross-sectional Study

Prevalence and associations of metabolic syndrome in patients with alcohol use disorder

Does bariatric surgery improves kidney function? A cohort study

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