Time course of phthalate cumulative risks to male developmental health over a 27-year period: Biomonitoring samples of the German Environmental Specimen Bank

Apel, Petra; Kortenkamp, Andreas; Koch, Holger M.; Vogel, Nina; Rüther, Maria; Kasper-Sonnenberg, Monika; Conrad, André; Brüning, Thomas; Kolossa-Gehring, Marike

doi:10.1016/j.envint.2020.105467

Cited by 36 publications

(20 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…35 Another study on 24 h urine samples collected from young adults (between 20 and 29 years old) participating in the German Environmental Specimen Bank between 1988 and 2015 shows that DnBP and DEHP were major risk drivers before 2000. 85 In both populations, however, MCRs became higher over time, showing increasing contribution of more phthalates to HI. 35,85 Although risks associated with the DEHP alternatives are deemed to be less critical, the observation that DEHTP metabolites were detected at similar or even higher levels compared to DEHP metabolites in the urine of Saudi children requires attention.…”

Section: ■ Discussionmentioning

confidence: 99%

Urinary Concentrations of Major Phthalate and Alternative Plasticizer Metabolites in Children of Thailand, Indonesia, and Saudi Arabia, and Associated Risks

Lee

Pälmke

Ringbeck

et al. 2021

Environ. Sci. Technol.

Self Cite

View full text Add to dashboard Cite

Phthalates are widely used in consumer products and are well-known for adverse endocrine outcomes. Di-(2-ethylhexyl) phthalate (DEHP), one of the most extensively used phthalates, has been rapidly substituted with alternative plasticizers in many consumer products. The aim of this study was to assess urinary phthalate and alternative plasticizer exposure and associated risks in children of three Asian countries with different geographical, climate, and cultural characteristics. Children were recruited from elementary schools of Saudi Arabia (n = 109), Thailand (n = 104), and Indonesia (n = 89) in 2017–2018, and their urine samples were collected. Metabolites of major phthalates and alternative plasticizers were measured in the urine samples by HPLC-MS/MS. Urinary metabolite levels differed substantially between the three countries. Metabolite levels of diisononyl phthalate (DiNP), diisodecyl phthalate (DiDP), di(2-ethylhexyl) terephthalate (DEHTP), and 1,2-cyclohexane dicarboxylic acid diisononyl ester (DINCH) were the highest in Saudi children: Median urinary concentrations of oxo-MiNP, OH-MiDP, 5cx-MEPTP, and OH-MINCH were 8.3, 8.4, 128.0, and 2.9 ng/mL, respectively. Urinary DEHP metabolite concentrations were the highest in the Indonesian children. The hazard index (HI) derived for the plasticizers with antiandrogenicity based reference doses (RfDAA) was >1 in 86%, 80%, and 49% of the Saudi, Indonesian, and Thai children, respectively. DEHP was identified as a common major risk driver for the children of all three countries, followed by DnBP and DiBP depending on the country. Among alternative plasticizers, urinary DEHTP metabolites were detected at levels comparable to those of DEHP metabolites or higher among the Saudi children, and about 4% of the Saudi children exceeded the health based human biomonitoring (HBM)-I value. Priority plasticizers that were identified among the children of three countries warrant refined exposure assessment for source identification and relevant exposure reduction measures.

show abstract

Section: ■ Discussionmentioning

confidence: 99%

Urinary Concentrations of Major Phthalate and Alternative Plasticizer Metabolites in Children of Thailand, Indonesia, and Saudi Arabia, and Associated Risks

Lee

Pälmke

Ringbeck

et al. 2021

Environ. Sci. Technol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…The MCR was also applied to evaluate the human health risk for anti-androgenicity of phthalates in a retrospective study that analysed 27 years of exposure data in 24-h urine samples from the German Environmental Specimen Bank (Apel et al, 2020). While RI decreased from 1.8 to 0.2 from 1985 to 2015, the MCR actually increased during this time from 1.5 to 1.9.…”

Section: Mixtures In Risk Assessment 841 Conceptsmentioning

confidence: 99%

Bioanalytical Tools in Water Quality Assessment

Neale¹,

Leusch²,

Escher³

2021

View full text Add to dashboard Cite

The first edition of Bioanalytical Tools in Water Quality Assessment was released in 2012. The field has exploded since and the second edition updates and reviews the application of bioanalytical tools for water quality assessment including surveillance monitoring. The book focuses on applications to water quality assessment ranging from wastewater to drinking water, including recycled water, as well as treatment processes and advanced water treatment. Emerging applications for other environmental matrices are also included. Bioanalytical Tools in Water Quality Assessment, Second Edition, not only demonstrates applications but also fills in the background knowledge in toxicology/ecotoxicology needed to appreciate these applications. Each chapter summarises fundamental material in a targeted way so that information can be applied to better understand the use of bioanalytical tools in water quality assessment. The book can be used by lecturers teaching academic and professional courses and also by risk assessors, regulators, experts, consultants, researchers and managers working in the water sector. It can also be a reference manual for environmental engineers, analytical chemists and toxicologists. ISBN: 9781789061970 (Paperback) ISBN: 9781789061987 (eBook)

show abstract

“…Non-carcinogenic risks induced byPAEs and BPA on human health were estimated using Hazard Quotient (HQ). This is determined using EDI, reference dose (RfD; ug/kg body weight/day) for increased mortality as reported in USEPA 2012, and RfD for anti-androgenicity 46,47 as follows:…”

Section: Human Health Risk Assessmentmentioning

confidence: 99%

Occurrence And Seasonal Disparity Of Emerging Endocrine Disrupting Chemicals In A Drinking Water Supply System And Associated Health Risk

Kumawat¹,

Sharma²,

Pal³

et al. 2022

Preprint

View full text Add to dashboard Cite

Contamination of drinking water with endocrine-disrupting chemicals (EDCs) raisesconcerns over the security and long-term sustainability of clean water supplies as well ashuman exposure via daily water intake. In this study, the seasonal disparity and occurrence ofsix phthalates and bisphenol A in the drinking water supply system and associated health risk wereexamined. DEHP was the most prevalent phthalate esters congener ranging from 1.14 - 8351.85 µg/L(winter) and 0.552 - 410.29 µg/L (summer) surpassing the permissible limit.Meanwhile, BPA concentrations were found under the permissible limit. The results suggested that PAEsconcentration displayed significant seasonal variations with the highest in winter and thelowest in the summer.The exposure toPAEs and BPA from drinking water was assessed, and the results indicated a possible healthrisk to humans with a Hazard Quotient (HQ) for DEHP.The findings necessitate an immediate scrutiny of these EDCs indrinking water supply system and are critical for implementing effective technologies at theWTP scale to ensure the quality and safety of drinking water in order to ascertain human andenvironmental health.

show abstract

Time course of phthalate cumulative risks to male developmental health over a 27-year period: Biomonitoring samples of the German Environmental Specimen Bank

Cited by 36 publications

References 65 publications

Urinary Concentrations of Major Phthalate and Alternative Plasticizer Metabolites in Children of Thailand, Indonesia, and Saudi Arabia, and Associated Risks

Urinary Concentrations of Major Phthalate and Alternative Plasticizer Metabolites in Children of Thailand, Indonesia, and Saudi Arabia, and Associated Risks

Bioanalytical Tools in Water Quality Assessment

Occurrence And Seasonal Disparity Of Emerging Endocrine Disrupting Chemicals In A Drinking Water Supply System And Associated Health Risk

Contact Info

Product

Resources

About