Time course of neuroprotection induced by normobaric hyperoxia in focal cerebral ischemia

Bigdeli, Mohammad Reza; Asheghabadi, Mahdieh; Khalili, Afshin

doi:10.1179/1743132812y.0000000013

Cited by 13 publications

(8 citation statements)

References 29 publications

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“…Apparent preconditioning can also be produced with hyperoxia,(Bigdeli et al, 2012) and hypercarbia/acidosis. (Ladilov, 2012; Tregub et al, 2016) These observations suggest that the blood gas derangements we anticipated might be associated with dysfunctions years later, can also provide neuroprotective benefits, and it is the balance between injury and these benefits that determines what we see.…”

Section: Discussionmentioning

confidence: 99%

Newborn blood gas derangements of children born extremely preterm and neurocognitive dysfunctions at age 10 years

Leviton

Allred

Joseph

et al. 2017

Respiratory Physiology & Neurobiology

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Among 740 children born extremely preterm, we evaluated the relationship between the highest and lowest quartiles of the distributions of PaO2 and PaCO2, as well as the lowest quartile of pH on one day, and separately on two days, and the risk of neurocognitive, language, and behavioral dysfunctions at age 10 years. Children who had hypoxemia, hyperoxemia, hypocapnia, hypercapnia, and acidemia, sometimes on only one day, and sometimes on two or more days, were more likely than others to have a high illness severity score (within the first 12 postnatal hours), and 10 years later to have multiple dysfunctions. The tendency of blood gas derangements to be associated with high illness severity scores and with multiple dysfunctions 10 years later is compatible with the possibility that blood gas derangements are indicators of physiologic instability/vulnerability/immaturity rather than contributors to brain damage.

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Section: Discussionmentioning

confidence: 99%

Newborn blood gas derangements of children born extremely preterm and neurocognitive dysfunctions at age 10 years

Leviton

Allred

Joseph

et al. 2017

Respiratory Physiology & Neurobiology

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“…Finite normobaric and hyperbaric hyperoxia can induce preconditioning in various experimental models [13], [68], and it has been especially investigated in neuroscience [69], [70]. A study showed that hyperoxic preconditioning (100% O 2 ) protected mesenchymal stem cells from subsequent hypoxia and downregulated caspases 1, 3, 6, 7 and 9 [71].…”

Section: Non-linear Response To Physiological Agentsmentioning

confidence: 99%

Non-linear actions of physiological agents: Finite disarrangements elicit fitness benefits

Sedlić

Kovač

2017

Redox Biology

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Finite disarrangements of important (vital) physiological agents and nutrients can induce plethora of beneficial effects, exceeding mere attenuation of the specific stress. Such response to disrupted homeostasis appears to be universally conserved among species. The underlying mechanism of improved fitness and longevity, when physiological agents act outside their normal range is similar to hormesis, a phenomenon whereby toxins elicit beneficial effects at low doses. Due to similarity with such non-linear response to toxins described with J-shaped curve, we have coined a new term “mirror J-shaped curves” for non-linear response to finite disarrangement of physiological agents. Examples from the clinical trials and basic research are provided, along with the unifying mechanisms that tie classical non-linear response to toxins with the non-linear response to physiological agents (glucose, oxygen, osmolarity, thermal energy, calcium, body mass, calorie intake and exercise). Reactive oxygen species and cytosolic calcium seem to be common triggers of signaling pathways that result in these beneficial effects. Awareness of such phenomena and exploring underlying mechanisms can help physicians in their everyday practice. It can also benefit researchers when designing studies and interpreting growing number of scientific data showing non-linear responses to physiological agents.

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“…26,29 There have also been benefits observed following cerebral ischaemia in rats, where arterial hyperoxaemia may provide a degree of neuroprotection. 27,28,30…”

Section: Can Hyperoxaemia Cause Harm?mentioning

confidence: 99%

“…There is also some evidence that hyperoxaemia may improve outcomes in some scenarios. [26][27][28] Following acute myocardial infarction, Bartorelli et al 26 found decreased infarct size and improved left ventricular function when angioplasty reperfusion was used with adjunctive hyperoxia. Both hyperbaric oxygen therapy and, more practically, aqueous oxygen delivery showed these benefits.…”

Section: Can Hyperoxaemia Cause Harm?mentioning

confidence: 99%

Is hyperoxaemia helping or hurting patients during extracorporeal membrane oxygenation? Review of a complex problem

Hayes

Shekar

2013

Perfusion

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Extracorporeal membrane oxygenation (ECMO) facilitates organ support in patients with refractory cardiorespiratory failure whilst disease-modifying treatments can be administered. Improvements to the ECMO process have resulted in its increased utilisation. However, iatrogenic injuries remain, with bleeding and thrombosis the most significant concerns. Many factors contribute to the formation of thrombi, with the hyperoxaemia experienced during ECMO a potential contributor. Outside of ECMO, emerging evidence associates hyperoxaemia with increased mortality. Currently, no universal definition of hyperoxaemia exists, a gap in clinical standards that may impact patient outcomes. Hyperoxaemia has the potential to induce platelet activation, aggregation and, subsequently, thrombosis through markedly increasing the production of reactive oxygen species. There are minimal data in the current literature that explore the relationship between ECMO-induced hyperoxaemia and the production of reactive oxygen species - a putative link towards pathology. Furthermore, there is limited research directly linking hyperoxaemia and platelet activation. These are areas that warrant investigation as definitive data regarding the nascence of these pathological processes may delineate and define the relative risk of supranormal oxygen tension. These data could then assist in defining optimal oxygenation practice, reducing the risks associated with extracorporeal support.

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Time course of neuroprotection induced by normobaric hyperoxia in focal cerebral ischemia

Abstract: In the model of transient focal cerebral ischemia, hyperoxia preconditioning induced effective but transient neuroprotective effects.

Cited by 13 publications

References 29 publications

Newborn blood gas derangements of children born extremely preterm and neurocognitive dysfunctions at age 10 years

Newborn blood gas derangements of children born extremely preterm and neurocognitive dysfunctions at age 10 years

Non-linear actions of physiological agents: Finite disarrangements elicit fitness benefits

Is hyperoxaemia helping or hurting patients during extracorporeal membrane oxygenation? Review of a complex problem

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