Time course of biochemical and behavioural effects of a single high dose of chlorpyrifos

López-Crespo, Ginesa; Carvajal, Francisca; Flores, Pilar; Sánchez-Santed, Fernando; Sánchez-Amate, M.C.

doi:10.1016/j.neuro.2007.01.013

Cited by 33 publications

(29 citation statements)

References 27 publications

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“…These substances bind to receptors in the GABA complex and directly or indirectly open the chloride channel, causing an influx of anions into the neuron, which results in the in hyperpolarization of the cell, producing an anxiety-like effect (Andreatini et al, 2001). Although rare, some studies involving contaminants in rodents demonstrate behaviors similar to those seen in this study (Stangherlin et al 2006;López-Crespo et al, 2007;Chen et al, 2011), supporting the hypothesis that the tannery effluent which was used may have acted similarly to these drugs.…”

Section: Resultssupporting

confidence: 80%

Behavioral changes in female Swiss mice exposed to tannery effluents

Almeida¹,

Rabelo²,

Souza³

et al. 2016

Rev. ambiente água

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Among the anthropic activities generating potentially toxic residues are those involved with bovine hide processing (tannery industries). However, knowledge is scant regarding the damage caused to the health of various organisms by tannery waste and studies are rare, especially in mammalian experimental models. This study therefore aimed to evaluate the physical and behavioral effects of the exposure of female Swiss mice to tannery effluent. To accomplish this, for a period of 15 days the animals were fed tannery effluent diluted with water in the following concentrations: 0% (control group, received only potable water), 5% and 10%. The body mass of the animals was evaluated at the beginning and end of the experiment, as well as the daily consumption of water and food. After 15 days of exposure to the effluent, the animals were submitted to the elevated plus maze (predictive of anxiety) and the forced swim test (predictive of depression). The treatments did not affect the animals' body mass, either in eating behavior or in consumption of water. However, it was found that the animals that ingested tannery effluent concentrations of 5% and 10% exhibited an anxiolytic (lower level of anxiety, greater percentage of time in the open arms, longer time and frequency in the diving behavior, less time of lurks and less frequency of freezing) and an antidepressant effect (more time in climbing behavior and less time of immobility) when compared to the control group. It was concluded that the exposure of female Swiss mice to tannery effluents (5% and 10% diluted with water) causes behavioral changes, possibly related to the neurotoxicity of this waste, without causing physical changes in the animals.Keywords: agricultural residues, animal model, anxiety, depression, toxicity, xenobiotics. Alterações comportamentais em fêmeas de camundongos

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Section: Resultssupporting

confidence: 80%

Behavioral changes in female Swiss mice exposed to tannery effluents

Almeida¹,

Rabelo²,

Souza³

et al. 2016

Rev. ambiente água

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“…In this long-term drinking model, changes in alcohol-drinking behavior occur over time between CPF and vehicle-treated rats. Thus, the CPF pretreated rats showed lower ethanol consumption and ethanol preference than the control group at 8, 15, and 20% ethanol concentration (Carvajal et al, 2007). These results are consistent with clinical and experimental data showing that exposure to organophosphates might be linked to increased ethanol sensitivity and reduced voluntary consumption of ethanol-containing beverages in humans.…”

Section: The Relationship Between Organophosphate Exposure and Ethanosupporting

confidence: 88%

“…Also, it has been shown that exposure to another pesticide, chlorpyrifos, causes alteration in several drug-induced responses. For example, tolerance to locomotor effects was shown after a dopaminergic agonist challenge with amphetamine 30 days after exposure to CPF (Lopez-Crespo et al, 2007). In a separate study, the motivational and reward properties of amphetamine were decreased in the place preference paradigm months after CPF administration .…”

Section: Environmental Neurotoxicants and Drug Abusementioning

confidence: 96%

See 1 more Smart Citation

Interaction Between Exposure to Neurotoxicants and Drug Abuse

Carvajal¹,

Sanchez-Amate²,

Lerma-Cabrera³

et al. 2012

Environmental Health - Emerging Issues and Practice

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“…A single dose of CPF (250 mg/kg) induces a maximum brain AChE inhibition 48 hr post-administration (Cardona et al, 2006;Lopez-Crespo et al, 2007), remaining inhibited at similar extent 4 days post-administration and slowly recovering over a period of approximately twelve weeks (Bushnell et al, 1993). In the present study biochemical indexes of CPF intoxication were collected at two different time-points.…”

Section: Brain Acetylcholinesterase Determinationmentioning

confidence: 99%