Time Course Effect of Thyroxine on Serum Lipoprotein Concentrations in Hypothyroid Subjects

Hylander, Britta; Rosenqvist, Urban

doi:10.1111/j.0954-6820.1982.tb01946.x

Cited by 7 publications

(1 citation statement)

References 17 publications

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“…[ 25 ] indicated that hypothyroid patients, who had received levothyroxine therapy, showed decreased levels of LDL-C, and total cholesterol as far as thyroid hormones reached normal levels. Hylander and Rosenqvist[ 26 ] also reported that levothyroxine therapy in hypothyroid patients with abnormal LDL could improve the LDL cholesterol level until TSH reached a normal level. The above results confirm the findings of the present study.…”

Section: Discussionmentioning

confidence: 99%

Investigating the effect of levothyroxine replacement on cholesterol levels in hypothyroid patients

Moradi,

Zaman,

Tangestani

et al. 2024

Journal of Family Medicine and Primary Care

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Introduction: Effects of levothyroxine therapy on the lipid profile of hypothyroid patients lead to decrease in the risk of cardiovascular diseases and mortality. Objective: Overt or subclinical hypothyroid dysfunction has negative effects on lipid metabolism and leads to hypercholesterolemia that in turn increases the risk of cardiovascular diseases and mortality. In this matter, several interventional studies investigated the effects of levothyroxine therapy on the lipid profile of hypothyroid patients, and conflicting results have been obtained. The current research aims to investigate the effect of levothyroxine replacement on cholesterol levels in hypothyroid patients. Methods: The present prospective study examined 112 patients (mean age of 43.80 ± 14.36 years) with overt hypothyroidism. To do so, 72.3% of patients were females. Levothyroxine replacement therapy was prescribed for patients, and they were examined monthly to evaluate the effects of therapy on their lipid profiles. After reaching normal thyroid stimulating hormone (TSH), the patients’ laboratory parameters, including TSH, total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides, were surveyed. Results: After Levothyroxine therapy, there was a significant reduction in mean TSH (62.03 vs. 2.33 ± 1.95; P < 0.0001), triglycerides (145.57 ± 88.65 vs. 121.91 ± 59.52, P = 0.002), cholesterol (203.90 ± 53.73 vs. 166.65 ± 40.07, P < 0.0001), and serum LDL (123.61 ± 45.03 vs. 95.99 ± 24.20, P < 0.0001), but the mean value of serum HDL did not show any significant change (54.18 ± 16.60 vs. 51.59 ± 18.38, P = 0.274). Conclusions: Levothyroxine therapy has beneficial effects on lipid profile in patients with overt hypothyroidism because it decreases serum triglyceride, total cholesterol, and LDL. However, levothyroxine therapy does not significantly change HDL levels.

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Section: Discussionmentioning

confidence: 99%

Investigating the effect of levothyroxine replacement on cholesterol levels in hypothyroid patients

Moradi,

Zaman,

Tangestani

et al. 2024

Journal of Family Medicine and Primary Care

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Systemic alterations in phospholipid concentrations of blood plasma in patients with thyroid carcinoma: anin-vitro31P high-resolution NMR study

et al. 2000

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Altered Thyroid Hormone Binding to Plasma Lipoproteins in Hypothyroidism

Benvenga

Robbins²

1996

Thyroid

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Iodothyronine binding to plasma lipoproteins (Lp) and gel filtration elution patterns of cholesterol and triglycerides were evaluated in the total lipoprotein fractions (TLF) obtained from 10 healthy blood donors and 7 patients with hypothyroidism of brief duration. TLF (d < 1.210 kg/L) shown to be free of plasma T4 transport proteins (TBG, TTR, HSA) was equilibrated with 0.3 nM 125I-labeled T4, T3 or reverse T3 (rT3) and chromatographed on Sepharose CL-6B. Percent distribution of rT3 among the Lp subtypes was similar in the two groups (in normals: VLDL = 4.2 +/- 2.4, LDL = 15.6 +/- 4.2, HDL = 79.9 +/- 5.2) but HDL in hypothyroid subjects bound significantly more T4 (98.7 +/- 0.4 vs. 91.2 +/- 0.3%) and T3 (95.5 +/- 2.6 vs. 78.3 +/- 11.3%). Correspondingly less T4 and T3 was bound to VLDL and LDL. Whereas rT3 elution coincided with the major HDL cholesterol peak (202 +/- 17 kDa) and was the same in the two groups, both T4 and T3 eluted with smaller HDL particles and differed between hypothyroid and normal subjects. T4 eluted with somewhat larger HDL particles in hypothyroid subjects (176 +/- 24 kDa vs. 111 +/- 34 kDa) and T3 eluted with smaller HDL (94 +/- 30 kDa vs. 148 +/- 31 kDa). The major HDL-cholesterol peak in hypothyroid subjects had a slightly but significantly greater mass than in normals (241 +/- 28 kDa vs. 218 +/- 14 kDa). The HDL elution patterns also differed: in normals there were from 3 to 6 minor peaks on either side of the major peak, whereas in hypothyroid subjects there were only 0 to 2 minor peaks. In conclusion, iodothyronines bind to relatively small size HDL subfractions and these are different for T4, T3, and rT3; hypothyroidism of brief duration induces both quantitative and qualitative changes in iodothyronine distribution among lipoproteins and alters the microheterogeneity of HDL-cholesterol.

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Time Course Effect of Thyroxine on Serum Lipoprotein Concentrations in Hypothyroid Subjects

Cited by 7 publications

References 17 publications

Investigating the effect of levothyroxine replacement on cholesterol levels in hypothyroid patients

Investigating the effect of levothyroxine replacement on cholesterol levels in hypothyroid patients

Systemic alterations in phospholipid concentrations of blood plasma in patients with thyroid carcinoma: anin-vitro31P high-resolution NMR study

Altered Thyroid Hormone Binding to Plasma Lipoproteins in Hypothyroidism

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