Systemic alterations in phospholipid concentrations of blood plasma in patients with thyroid carcinoma: anin-vitro31P high-resolution NMR study

Raffelt, Klaus; Moka, D.; Süllentrop, Frauke; Dietlein, Markus; Hahn, Josef; Schicha, H.

doi:10.1002/(sici)1099-1492(200002)13:1<8::aid-nbm602>3.0.co;2-x

Cited by 32 publications

(8 citation statements)

References 13 publications

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“…This is in accordance with the findings of other groups [44][45][46][47]. Even more astonishing was our finding that especially those patients suffering from tumor-associated weight loss displayed low lyso-PC serum levels [35].…”

Section: Discussionsupporting

confidence: 93%

Marine phospholipids—a promising new dietary approach to tumor-associated weight loss

Taylor¹,

Pletschen

Arends

et al. 2009

Support Care Cancer

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Section: Discussionsupporting

confidence: 93%

Marine phospholipids—a promising new dietary approach to tumor-associated weight loss

Taylor¹,

Pletschen

Arends

et al. 2009

Support Care Cancer

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“…In comparison with normal tissues, thyroid carcinoma tissues from patients had a significant increase in lecithin, SM, and cholesterol [72]. Changes of the SM content together with other lipids in the blood plasma of patients with thyroid carcinoma were reported [73]. Serum lipidomic profiling with a panel which included 36:3phosphatidic acid (PA) and 34:1SM can be useful to distinguish between malignant thyroid cancer and benign thyroid tumors [74].…”

Section: Biomarkers Of Thyroid Damagementioning

confidence: 99%

Radiation and Thyroid Cancer

Albi

Cataldi

Lazzarini

et al. 2017

IJMS

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Radiation-induced damage is a complex network of interlinked signaling pathways, which may result in apoptosis, cell cycle arrest, DNA repair, and cancer. The development of thyroid cancer in response to radiation, from nuclear catastrophes to chemotherapy, has long been an object of study. A basic overview of the ionizing and non-ionizing radiation effects of the sensitivity of the thyroid gland on radiation and cancer development has been provided. In this review, we focus our attention on experiments in cell cultures exposed to ionizing radiation, ultraviolet light, and proton beams. Studies on the involvement of specific genes, proteins, and lipids are also reported. This review also describes how lipids are regulated in response to the radiation-induced damage and how they are involved in thyroid cancer etiology, invasion, and migration and how they can be used as both diagnostic markers and drug targets.

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“…However, it would have been consistent if LPC values before giving MPL were also lower in metastasized PCa patients when compared to all other subjects, but no differences were observed before intervention. An explanation could be that all subjects had already low LPC values (181 μ M, normal values range from 200 to 400 μ M [ 32 – 35 ]).…”

Section: Discussionmentioning

confidence: 99%

Effects of Marine Phospholipids Extract on the Lipid Levels of Metastatic and Nonmetastatic Prostate Cancer Patients

Gaudry

Taylor

Kluth³

et al. 2014

International Scholarly Research Notices

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High intake of omega-3 fatty acids (n-3 FAs) from fish has shown to reduce metastatic progression of prostate cancer. This clinical trial investigated the influence of high n-3 FA intake (marine phospholipids, MPL) on the FA composition of blood lipids, lysophosphatidylcholine (LPC), and on lipoproteins in prostate cancer patients and elderly men without prostate cancer. MPL supplementation resulted in a significant increase of n-3 FAs (eicosapentaenoic and docosahexaenoic acid) in blood lipids, while arachidonic acid (n-6 FA) decreased significantly. Low density lipoprotein (LDL) and high density lipoprotein (HDL) increased significantly, but the LDL increase was observed only in subjects with an inactive tumour. Similarly, LPC plasma concentration increased significantly only in patients without tumour. The missing increase of LDL and LPC after MPL supplementation in patients with actively growing (metastasizing) prostate cancer suggests that tumour cells have an elevated demand for LDL and LPC. Due to the MPL-induced increase of n-3 FAs in these blood lipids, it can be assumed that especially actively growing and metastasizing prostate cancer cells are provided with elevated amounts of these antimetastatic n-3 FAs. A hypothetic model explaining the lower incidence of metastatic progression in prostate cancer patients with high fish consumption is presented.

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Systemic alterations in phospholipid concentrations of blood plasma in patients with thyroid carcinoma: anin-vitro31P high-resolution NMR study

Cited by 32 publications

References 13 publications

Marine phospholipids—a promising new dietary approach to tumor-associated weight loss

Marine phospholipids—a promising new dietary approach to tumor-associated weight loss

Radiation and Thyroid Cancer

Effects of Marine Phospholipids Extract on the Lipid Levels of Metastatic and Nonmetastatic Prostate Cancer Patients

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