Time Course and Regional Distribution of Cortical Changes During Acute Alcohol Ingestion

Tran, Yvonne; Craig, Ashley; Bartrop, Roger; Nicholson, Graham M.

doi:10.1080/00207450490450055

Cited by 9 publications

(9 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our EEG results revealed a relative power increase between alcohol and placebo conditions in the theta band (see Fig. ), as already documented in early EEG investigations [Ehlers et al, ; Sanz‐Martin et al, ; Schwarz et al, ; Tran et al, ]. More recent studies have related this specific EEG signature to an increased sensation of euphoria induced by alcohol.…”

Section: Discussionsupporting

confidence: 89%

“…More recent studies have related this specific EEG signature to an increased sensation of euphoria induced by alcohol. Specifically, Tran and colleagues interpreted this finding as a result of low cortical arousal during the ascending phase of alcohol intoxication [Tran et al, ], whereas Schwartz and coworkers suggested that the theta power increase is instead due to a de‐inhibition [Schwarz et al, ]. A further issue left unresolved by EEG studies concerns the neuronal generators of this specific theta‐band activity.…”

Section: Discussionmentioning

confidence: 99%

“…EEG and fMRI studies have documented that both brain rhythms and network interactions can be experimentally modulated by administration of small amount of alcohol at rest. Specifically, EEG studies showed that alcohol administration induced an increase in the power of the theta rhythm [Schwarz et al, ], mainly located over the frontal cortex [Tran et al, ] and persistent up to two hours after ingestion [Ehlers et al, ]. FMRI investigations revealed changes in cortical activation after alcohol intoxication [Calhoun et al, ; Levin et al, ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Neuronal oscillations and functional interactions between resting state networks

et al. 2013

View full text Add to dashboard Cite

Functional magnetic imaging (fMRI) studies showed that resting state activity in the healthy brain is organized into multiple large-scale networks encompassing distant regions. A key finding of resting state fMRI studies is the anti-correlation typically observed between the dorsal attention network (DAN) and the default mode network (DMN), which - during task performance - are activated and deactivated, respectively. Previous studies have suggested that alcohol administration modulates the balance of activation/deactivation in brain networks, as well as it induces significant changes in oscillatory activity measured by electroencephalography (EEG). However, our knowledge of alcohol-induced changes in band-limited EEG power and their potential link with the functional interactions between DAN and DMN is still very limited. Here we address this issue, examining the neuronal effects of alcohol administration during resting state by using simultaneous EEG-fMRI. Our findings show increased EEG power in the theta frequency band (4-8 Hz) after administration of alcohol compared to placebo, which was prominent over the frontal cortex. More interestingly, increased frontal tonic EEG activity in this band was associated with greater anti-correlation between the DAN and the frontal component of the DMN. Furthermore, EEG theta power and DAN-DMN anti-correlation were relatively greater in subjects who reported a feeling of euphoria after alcohol administration, which may result from a diminished inhibition exerted by the prefrontal cortex. Overall, our findings suggest that slow brain rhythms are responsible for dynamic functional interactions between brain networks. They also confirm the applicability and potential usefulness of EEG-fMRI for central nervous system drug research.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Neuronal oscillations and functional interactions between resting state networks

et al. 2013

View full text Add to dashboard Cite

show abstract

“…In another study, Lukas et al (1986) administered two doses of alcohol (0.347 and 0.695 g/kg) to young men and observed that during the absorption phase, alcohol intoxication resulted in increases in a activity that were positively related to euphoric sensations in the drinkers, whereas during the second phase, both doses of alcohol produced an increase in y activity. Similar results have been reported in other studies with similar alcohol doses (Tran et al, 2004). For example, Sanz-Martin et al…”

Section: Introductionsupporting

confidence: 85%

Effects of alcohol on the performance of the Tower of London task in relation to the menstrual cycle

Sanz-Martín

Hernández‐González

Guevara

et al. 2012

Behavioural Pharmacology

View full text Add to dashboard Cite

It is well known that the metabolism of alcohol and cognitive functions can vary during the menstrual cycle. Also, both alcohol ingestion and hormonal variations during menstruation have been associated with characteristic changes in electroencephalographic (EEG) activity. The aim of the present study was to determine whether EEG activity during the performance of the Tower of London (TOL) task is affected by previous ingestion of alcohol and whether these EEG patterns vary in relation to different phases of the menstrual cycle. For this purpose, female participants consumed a moderate dose of alcohol or placebo during the follicular and early luteal phases of the menstrual cycle and then, 35 min after liquid ingestion, EEG activity was recorded during the performance of TOL. A deleterious effect of alcohol on TOL performance was potentiated in the follicular phase, related to a higher α1 relative power, probably as a result of the low progesterone levels characteristic of this menstrual phase. These data show the feasibility of examining the interaction of alcohol and menstrual cycle phases on cognitive performance by means of EEG recording, and contribute toward a better understanding of the brain mechanisms that underlie the cognitive changes that occur during the menstrual cycle under the effects of alcohol.

show abstract

“…The acute administration of ethanol consistently increases theta and alpha power (particularly within the lower-1 alpha frequency range, 8–10 Hz; e.g. Ilan and Gevins 2001; Lukas et al 1986; Stenberg et al 1994; Tran et al 2004), although alpha power returned to normal levels 60 min after ethanol administration (Lukas et al 1986). Increased alpha power after alcohol consumption has been shown to correlate positively with feelings of euphoria (Lukas et al 1986).…”

Section: Introductionmentioning

confidence: 99%

Acute effects of MDMA (3,4-methylenedioxymethamphetamine) on EEG oscillations: alone and in combination with ethanol or THC (delta-9-tetrahydrocannabinol)

et al. 2010

View full text Add to dashboard Cite

RationaleTypical users of 3,4-methylenedioxymethamphetamine (MDMA or “ecstasy”) are polydrug users, combining MDMA with alcohol or cannabis [most active compound: delta-9-tetrahydrocannabinol (THC)].ObjectivesThe aim of the present study was to investigate whether co-administration of alcohol or THC with MDMA differentially affects ongoing electroencephalogram (EEG) oscillations compared to the administration of each drug alone.MethodsIn two separate experiments, 16 volunteers received four different drug conditions: (1) MDMA (100 mg); (2) alcohol clamp (blood alcohol concentration = 0.6‰) or THC (inhalation of 4, 6 and 6 mg, interval of 1.5 h); (3) MDMA in combination with alcohol or THC; and (4) placebo. Before and after drug administration, electroencephalography was recorded during an eyes closed resting state.ResultsTheta and alpha power increased after alcohol intake compared to placebo and reduced after MDMA intake. No interaction between alcohol and MDMA was found. Significant MDMA × THC effects for theta and lower-1-alpha power indicated that the power attenuation after the combined intake of MDMA and THC was less than the sum of each drug alone. For the lower-2-alpha band, the intake of MDMA or THC alone did not significantly affect power, but the intake of combined MDMA and THC significantly decreased lower-2-alpha power.ConclusionsThe present findings indicate that the combined intake of MDMA and THC, but not of MDMA and alcohol, affects ongoing EEG oscillations differently than the sum of either one drug alone. Changes in ongoing EEG oscillations may be related to the impaired task performance that has often been reported after drug intake.

show abstract

Time Course and Regional Distribution of Cortical Changes During Acute Alcohol Ingestion

Cited by 9 publications

References 17 publications

Neuronal oscillations and functional interactions between resting state networks

Neuronal oscillations and functional interactions between resting state networks

Effects of alcohol on the performance of the Tower of London task in relation to the menstrual cycle

Acute effects of MDMA (3,4-methylenedioxymethamphetamine) on EEG oscillations: alone and in combination with ethanol or THC (delta-9-tetrahydrocannabinol)

Contact Info

Product

Resources

About