Acute effects of MDMA (3,4-methylenedioxymethamphetamine) on EEG oscillations: alone and in combination with ethanol or THC (delta-9-tetrahydrocannabinol)

Lansbergen, Marieke M.; Dumont, Glenn; Gerven, Joop M. A. van; Buitelaar, Jan K.; Verkes, Robbert‐Jan

doi:10.1007/s00213-010-2031-4

Cited by 16 publications

(15 citation statements)

References 61 publications

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“…Overall, effects of the pharmacological manipulation with moderate alcohol intoxication were weaker than the EOC effects, with alcohol increasing power in alpha and beta bands, especially under the eyes-closed condition. Our observation of alcohol-induced alpha increase is consistent with other evidence obtained with EEG (Kaplan, Hesselbrock, O’Connor, & DePalma, 1988; Lansbergen, Dumont, van Gerven, Buitelaar, & Verkes, 2011; Lukas, Mendelson, Kouri, Bolduc, & Amass, 1990). Furthermore, the increase in alpha power during alcohol challenge is higher in the offspring of alcoholics (Cohen, Porjesz, & Begleiter, 1993; Ehlers & Schuckit, 1991).…”

Section: Discussionsupporting

confidence: 93%

Oscillatory spatial profile of alcohol's effects on the resting state: Anatomically-constrained MEG

Rosen

O’Hara

Kovacevic

et al. 2014

Alcohol

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It has been firmly established that opening and closing the eyes strongly modulate the electro- and magnetoencephalography (EEG and MEG) signals acquired during wakeful rest. Certain features of the resting EEG are altered in chronic alcoholics and their offspring, and have been proposed as biomarkers for alcoholism. Spontaneous brain oscillations are also affected by pharmacological manipulations, but the spectral and spatial characteristics of these changes are not clear. This study examined effects of the eyes-open (EO) and eyes-closed (EC) resting paradigm and alcohol challenge on the spatial profile of spontaneous MEG and EEG oscillations. Whole-head MEG and scalp EEG signals were acquired simultaneously from healthy social drinkers (n = 17) who participated in both alcohol (0.6 g/kg ethanol for men, 0.55 g/kg for women) and placebo conditions in a counterbalanced design. Power of the signal was calculated with Fast Fourier Transform and was decomposed into its constituent theta (4–7 Hz), alpha (8–12 Hz), and beta (15–20 Hz) frequency bands. High-resolution structural MRI images were additionally obtained from all participants and used to constrain distributed minimum norm inverse source power estimates. The spatial estimates of the main generator nodes were in agreement with studies using a combined fMRI-EEG approach. Alpha band oscillations dominated the spectral profile and their source was estimated to the medial parieto-occipital area. Power in theta and beta bands was weaker overall and their sources were estimated to a more focal medial prefrontal area. EO and EC manipulation most strongly modulated power in the alpha band, but a wide-band power increase was observed during the EC condition. Alcohol intoxication increased alpha power, particularly during the EC condition. Application of this methodology to cohorts of chronic alcoholics or individuals at risk could potentially provide insight into the neural basis of oscillatory differences that may be predictive of the vulnerability to alcoholism.

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Section: Discussionsupporting

confidence: 93%

Oscillatory spatial profile of alcohol's effects on the resting state: Anatomically-constrained MEG

Rosen

O’Hara

Kovacevic

et al. 2014

Alcohol

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“…Furthermore, 5-HT is linked to the psychological effect of many psychotropic drugs; specifically, 5-HT 2A R activation has been reported to be essential for the psychological effects induced by various psychedelics ( Nichols, 2016 ), and in the case of MDMA, has been linked to perceptual and emotional alterations ( Liechti et al, 2000 ; Kuypers et al, 2018 ). Broadband reduction in oscillatory power, triggered by 5-HT 2A R, seems to be linked to the subjective effect of serotonergic drugs ( Carhart-Harris et al, 2016 ; Carhart-Harris and Friston, 2019 ) and has been consistently observed in humans and rodents following administration of MDMA ( Frei et al, 2001 ; Lansbergen et al, 2011 ) or various other 5-HT 2A R agonists ( Kometer et al, 2015 ; Muthukumaraswamy et al, 2013 ; Carhart-Harris et al, 2016 ; Wood et al, 2012 ). The link between 5-HT 2A R and perception is further supported by the fact that several routinely used antipsychotic drugs are potent 5-HT 2A R antagonists ( Marek et al, 2003 ; Meltzer, 1999 ).…”

Section: Discussionmentioning

confidence: 99%

Somatostatin interneurons activated by 5-HT2A receptor suppress slow oscillations in medial entorhinal cortex

Filippo

Rost

Stumpf

et al. 2021

eLife

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Serotonin (5-HT) is one of the major neuromodulators present in the mammalian brain and has been shown to play a role in multiple physiological processes. The mechanisms by which 5-HT modulates cortical network activity, however, are not yet fully understood. We investigated the effects of 5-HT on slow oscillations (SOs), a synchronized cortical network activity universally present across species. SOs are observed during anesthesia and are considered to be the default cortical activity pattern. We discovered that (±)3,4-methylenedioxymethamphetamine (MDMA) and fenfluramine, two potent 5-HT releasers, inhibit SOs within the entorhinal cortex (EC) in anesthetized mice. Combining opto- and pharmacogenetic manipulations with in vitro electrophysiological recordings, we uncovered that somatostatin-expressing (Sst) interneurons activated by the 5-HT2A receptor (5-HT2AR) play an important role in the suppression of SOs. Since 5-HT2AR signaling is involved in the etiology of different psychiatric disorders and mediates the psychological effects of many psychoactive serotonergic drugs, we propose that the newly discovered link between Sst interneurons and 5-HT will contribute to our understanding of these complex topics.

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“…Addictive substances have been found to alter brain electrical wave activities (Ceballos et al, 2009; Custodio et al, 2019; Lansbergen et al, 2011). Consistently, MAL and BOD, similar to METH, increased delta and gamma waves in mice.…”

Section: Discussionmentioning

confidence: 99%

Two newly-emerging substituted phenethylamines MAL and BOD induce differential psychopharmacological effects in rodents

et al. 2020

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Background: Recently, the recreational use of substituted phenethylamines has grown rapidly. Among these are 2-(3,5-dimethoxy-4-((2-methylallyl)oxy)phenyl)ethanamine (MAL) and 2-(2,5-dimethoxy-4-methylphenyl)-2-methoxyethan-1-amine (BOD). However, studies characterizing their abuse potential are still lacking. Aim: The purpose of this study was to investigate the abuse potential of MAL and BOD. Methods: The psychostimulant, reinforcing, and rewarding properties of MAL and BOD were analyzed using locomotor sensitization, self-administration, and conditioned place preference tests. Dopamine antagonists (i.e. SCH23390, haloperidol) were administered during conditioned place preference to evaluate the involvement of the mesolimbic dopamine system. Furthermore, dopamine-related protein expression in the nucleus accumbens and the ventral tegmental area was measured along with dopamine concentrations in the nucleus accumbens. Electroencephalography was conducted to determine effects of MAL and BOD on brain wave activity. Results: MAL induced psychostimulant effects and sensitization, while BOD induced locomotor depression in mice. Only MAL was self-administered by rats. Both drugs induced conditioned place preference in mice at different doses; dopamine receptor antagonists blocked MAL- and BOD-induced conditioned place preference. Both the compounds altered the expression of dopamine receptor D1 and D2 proteins in the nucleus accumbens and tyrosine hydroxylase (TH) and dopamine transporter in the ventral tegmental area, enhanced dopamine levels in the nucleus accumbens, and increased delta and gamma wave activities in the brain. Conclusions: MAL may induce abuse potential via the mesolimbic dopaminergic system and possibly accompanied by alterations in brain wave activity. Moreover, the lack of rewarding and reinforcing effects in BOD suggest that this drug may have little to no capability to engender compulsive behavior, though having found to induce alterations in dopaminergic system and brain wave activities.

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Acute effects of MDMA (3,4-methylenedioxymethamphetamine) on EEG oscillations: alone and in combination with ethanol or THC (delta-9-tetrahydrocannabinol)

Cited by 16 publications

References 61 publications

Oscillatory spatial profile of alcohol's effects on the resting state: Anatomically-constrained MEG

Oscillatory spatial profile of alcohol's effects on the resting state: Anatomically-constrained MEG

Somatostatin interneurons activated by 5-HT2A receptor suppress slow oscillations in medial entorhinal cortex

Two newly-emerging substituted phenethylamines MAL and BOD induce differential psychopharmacological effects in rodents

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