Time and dose-dependent effects of Labisia pumila on the bone strength of postmenopausal osteoporosis rat model

Effendy, Nadia Mohd; Abdullah, Shahrum; Yunoh, Mohd Faridz Mod; Shuid, Ahmad Nazrun

doi:10.1186/s12906-015-0567-x

“…Sprague Dawley rats are a valuable model for the induction of osteoporosis after hormonal depletion via ovariectomy [43, 44]. Here, the rats were 13 weeks old at the time of ovariectomy, which is reportedly acceptable for the osteoporosis model [45, 46].…”

Section: Discussionmentioning

confidence: 99%

Effect of the Lipoxygenase Inhibitor Baicalein on Muscles in Ovariectomized Rats

Saul

¹

,

Kling

²

,

Kosinsky

³

et al. 2016

Journal of Nutrition and Metabolism

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Sarcopenia, a loss of muscle mass accompanying osteoporosis, leads to falls and fall-related injuries. Baicalein, as a phytochemical agent, has an antioxidative and anti-inflammatory effect in muscle. In this study, sixty-one female Sprague Dawley rats were divided into five groups: four groups were ovariectomized (OVX) and one control group was nonovariectomized (NON-OVX). Eight weeks after ovariectomy, three disparate concentrations (1 mg/kg body weight (BW), 10 mg/kg BW, and 100 mg/kg BW) of baicalein were applied subcutaneously daily in three OVX groups. Mm. soleus, gastrocnemius, and longissimus were extracted; their diameter, area, relation to body, and muscle weights as well as number of capillaries per fibre were recorded. In Mm. soleus and gastrocnemius, the baicalein effect (increasing number of capillaries per fibre) was proportional to the dose applied. The fibre diameters and area under baicalein treatment were significantly greater compared to OVX and NON-OVX groups. In M. longissimus, we observed a shift to type IIa fibres. Serum creatine kinase levels were significantly lower in highest baicalein concentration group. We conclude that baicalein can stimulate angiogenesis, though not fibre type-specific, in skeletal muscle and reduce the estrogen-related loss of fibre diameter and area in the skeletal muscle in rats. Therefore, a protective effect of baicalein on muscle cells can be assumed.

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“…Sprague Dawley rats are a valuable model for the induction of osteoporosis after hormonal depletion via ovariectomy [43,44]. Here, the rats were 13 weeks old at the time of ovariectomy, which is reportedly acceptable for the osteoporosis model [45,46].…”

Section: Discussionmentioning

confidence: 99%

Effect of the lipoxygenase inhibitor baicalein on muscles in ovariectomized rats

Saul¹

2017

Preprint

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Sarcopenia, a loss of muscle mass accompanying osteoporosis, leads to falls and fall-related injuries. Baicalein, as a phytochemical agent, has an antioxidative and anti-inflammatory effect in muscle. In this study, sixty-one female Sprague Dawley rats were divided into five groups: four groups were ovariectomized (OVX) and one control group was nonovariectomized (NON-OVX). Eight weeks after ovariectomy, three disparate concentrations (1 mg/kg body weight (BW), 10 mg/kg BW, and 100 mg/kg BW) of baicalein were applied subcutaneously daily in three OVX groups. Mm. soleus, gastrocnemius, and longissimus were extracted; their diameter, area, relation to body, and muscle weights as well as number of capillaries per fibre were recorded. In Mm. soleus and gastrocnemius, the baicalein effect (increasing number of capillaries per fibre) was proportional to the dose applied. The fibre diameters and area under baicalein treatment were significantly greater compared to OVX and NON-OVX groups. In M. longissimus, we observed a shift to type IIa fibres. Serum creatine kinase levels were significantly lower in highest baicalein concentration group. We conclude that baicalein can stimulate angiogenesis, though not fibre type-specific, in skeletal muscle and reduce the estrogen-related loss of fibre diameter and area in the skeletal muscle in rats. Therefore, a protective effect of baicalein on muscle cells can be assumed.

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“…The herbal plant traditionally known as Kacip Fatimah ( Labisia pumila ) belongs to the family Myrsinaceae [ 99 , 100 ]. Labisia pumila water extract is traditionally used by Malay women to treat menstrual irregularities and dysmenorrhoea [ 99 , 100 ]. It is also used to improve uterine contraction post-delivery and to promote sexual function [ 99 , 100 ].…”

Section: Antiosteoporotic Constituents Extracted From Natural Planmentioning

confidence: 99%

“…Labisia pumila water extract is traditionally used by Malay women to treat menstrual irregularities and dysmenorrhoea [ 99 , 100 ]. It is also used to improve uterine contraction post-delivery and to promote sexual function [ 99 , 100 ]. Its water extract is also being consumed to treat diseases such as gonorrhoea, rheumatism, dysentery, and bone disorders [ 101 ].…”

Section: Antiosteoporotic Constituents Extracted From Natural Planmentioning

confidence: 99%

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Protective Effects of Selected Botanical Agents on Bone

Jolly

¹

,

Chin

²

,

Alias

³

et al. 2018

IJERPH

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Osteoporosis is a serious health problem affecting more than 200 million elderly people worldwide. The early symptoms of this disease are hardly detectable. It causes progressive bone loss, which ultimately renders the patients susceptible to fractures. Osteoporosis must be prevented because the associated fragility fractures result in high morbidity, mortality, and healthcare costs. Many plants used in herbal medicine contain bioactive compounds possessing skeletal protective effects. This paper explores the anti-osteoporotic properties of selected herbal plants, including their actions on osteoblasts (bone forming cells), osteoclasts (bone resorbing cells), and bone remodelling. Some of the herbal plant families included in this review are Berberidaceae, Fabaceae, Arecaceae, Labiatae, Simaroubaceaea, and Myrsinaceae. Their active constituents, mechanisms of action, and pharmaceutical applications were discussed. The literature shows that very few herbal plants have undergone human clinical trials to evaluate their pharmacological effects on bone to date. Therefore, more intensive research should be performed on these plants to validate their anti-osteoporotic properties so that they can complement the currently available conventional drugs in the battle against osteoporosis.

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Time and dose-dependent effects of Labisia pumila on the bone strength of postmenopausal osteoporosis rat model

Cited by 16 publications

References 87 publications

Effect of the Lipoxygenase Inhibitor Baicalein on Muscles in Ovariectomized Rats

Effect of the Lipoxygenase Inhibitor Baicalein on Muscles in Ovariectomized Rats

Effect of the lipoxygenase inhibitor baicalein on muscles in ovariectomized rats

Protective Effects of Selected Botanical Agents on Bone

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