Time and depth dependent poisson’s ratio of cartilage explained by an inhomogeneous orthotropic fiber embedded biphasic model

Chegini, Salman; Ferguson, Stephen J.

doi:10.1016/j.jbiomech.2010.03.006

Cited by 34 publications

(24 citation statements)

References 32 publications

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“…Local areas of high deformation can be taken into account the initiation points for tissue fibrillation or delamination and these local peaks are not anticipated by an isotropic model. However, a model without fibers is failed to address the reaction force in compression, 14 which is the most important point for growth of most fiber-reinforced models. Although CSM model is one of the simplest fiberreinforced models presented for articular cartilage, it has the potential ability to address the anisotropic mechanical behavior of articular cartilage under various loading conditions.…”

Section: Resultsmentioning

confidence: 99%

“…13 These experiments test can provide us with a comprehensive understanding of the cartilage mechanical behavior and an initial step for the growth of computational and mathematical models. 14 There have been introduced many material models to characterize the mechanical behavior of articular cartilage. These models introduced from relatively simple ones, including the biphasic nature of the articular cartilage, to models that consist descriptions of all main specific components of cartilage.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

An Innovative Randomly Oriented Laminated Composite Model for Articular Cartilage Tissue

Elhamian

Alizadeh²,

Shokrieh³

et al. 2014

j biomater tissue eng

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An Innovative Randomly Oriented Laminated Composite Model for Articular Cartilage Tissue

Elhamian

Alizadeh²,

Shokrieh³

et al. 2014

j biomater tissue eng

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“…By using the aggregate modulus from the experimental measurements in these zones, the collagen fibers volume fractions of the superficial and deep zones have been calculated as 0.22 and 0.20, respectively. Assuming a linear variation of the volume fraction from the superficial zone to deep zone [31], depth dependent collagen fiber volume fraction is determined by:…”

Section: Mechanical Properties Of the Transition Zonementioning

confidence: 99%

A depth dependent transversely isotropic micromechanic model of articular cartilage

Elhamian

Alizadeh

Shokrieh

et al. 2015

J Mater Sci: Mater Med

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“…Healthy adult AC is characterised by a depth-dependent composition [1-3] and structure [4-7]. These characteristics result in depth-dependent mechanical properties [8-11] that are important for the functions of adult AC, specifically load distribution and the establishment of a low friction environment [11-13]. …”

Section: Introductionmentioning

confidence: 99%

Postnatal development of depth-dependent collagen density in ovine articular cartilage

et al. 2010

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BackgroundArticular cartilage (AC) is the layer of tissue that covers the articulating ends of the bones in diarthrodial joints. Adult AC is characterised by a depth-dependent composition and structure of the extracellular matrix that results in depth-dependent mechanical properties, important for the functions of adult AC. Collagen is the most abundant solid component and it affects the mechanical behaviour of AC. The current objective is to quantify the postnatal development of depth-dependent collagen density in sheep (Ovis aries) AC between birth and maturity. We use Fourier transform infra-red micro-spectroscopy to investigate collagen density in 48 sheep divided over ten sample points between birth (stillborn) and maturity (72 weeks). In each animal, we investigate six anatomical sites (caudal, distal and rostral locations at the medial and lateral side of the joint) in the distal metacarpus of a fore leg and a hind leg.ResultsCollagen density increases from birth to maturity up to our last sample point (72 weeks). Collagen density increases at the articular surface from 0.23 g/ml ± 0.06 g/ml (mean ± s.d., n = 48) at 0 weeks to 0.51 g/ml ± 0.10 g/ml (n = 46) at 72 weeks. Maximum collagen density in the deeper cartilage increases from 0.39 g/ml ± 0.08 g/ml (n = 48) at 0 weeks to 0.91 g/ml ± 0.13 g/ml (n = 46) at 72 weeks. Most collagen density profiles at 0 weeks (85%) show a valley, indicating a minimum, in collagen density near the articular surface. At 72 weeks, only 17% of the collagen density profiles show a valley in collagen density near the articular surface. The fraction of profiles with this valley stabilises at 36 weeks.ConclusionsCollagen density in articular cartilage increases in postnatal life with depth-dependent variation, and does not stabilize up to 72 weeks, the last sample point in our study. We find strong evidence for a valley in collagen densities near the articular surface that is present in the youngest animals, but that has disappeared in the oldest animals. We discuss that the retardance valley (as seen with polarised light microscopy) in perinatal animals reflects a decrease in collagen density, as well as a decrease in collagen fibril anisotropy.

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Time and depth dependent poisson’s ratio of cartilage explained by an inhomogeneous orthotropic fiber embedded biphasic model

Cited by 34 publications

References 32 publications

An Innovative Randomly Oriented Laminated Composite Model for Articular Cartilage Tissue

An Innovative Randomly Oriented Laminated Composite Model for Articular Cartilage Tissue

A depth dependent transversely isotropic micromechanic model of articular cartilage

Postnatal development of depth-dependent collagen density in ovine articular cartilage

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