A depth dependent transversely isotropic micromechanic model of articular cartilage

Elhamian, Seyed Mohammad Mehdi; Alizadeh, Mansour; Shokrieh, M.M.; Karimi, Alireza

doi:10.1007/s10856-015-5449-8

Cited by 8 publications

(8 citation statements)

References 34 publications

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“…They apply dynamic compression loading which is similar to the natural physiological loading of cartilage. Compression bioreactors can improve mass formation and increase the elastic modules of the cartilage formed to approach that of native cartilage [21,22]. Mauck et al in 2000 seeded cells on agarose disks in dynamic compressions with a peakto-peak compressive strain amplitude of 10% at a frequency of 1 Hz, 3 times (1 hour on, 1 hour off)/day, 5 days per week for 4 weeks resulted in a six-fold increase in the equilibrium aggregate modulus over free swelling controls after 28 days of loading (100 ± 16 kPa versus 15 ± 8 kPa, p < 0.0001).…”

Section: Bioreactors For Inducing Compressionmentioning

confidence: 99%

Bioreactors for tissue engineering: An update

Zhao

Griffin

Cai

et al. 2016

Biochemical Engineering Journal

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One of the greatest puzzles in wound healing is how to substitute or replace the defect caused by loss and damaged tissue or organs. In regenerative medicine, Tissue Engineering has been proposed to supply this demand by generating tissues in vitro. Bioreactors are the key to translate these cells and tissue-based constructs into large-scale biological products that are clinically effective, safe and financially pliable. In this review, we summarise the different upto-date bioreactor designs being used for different cell types and special design scaffolds, and highlight advantages of different bioreactors, current challenges and the future trends. It is our belief that with efforts combined from multiple disciplinary participants, a novel bioreactor system that is capable of fast, large scale tissue culture would come about in near future.

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Section: Bioreactors For Inducing Compressionmentioning

confidence: 99%

Bioreactors for tissue engineering: An update

Zhao

Griffin

Cai

et al. 2016

Biochemical Engineering Journal

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“…Mauck et al [135] demonstrated that the application of dynamic deformational loading at physiological strain levels enhances chondrocyte matrix elaboration in cell-seeded agarose scaffolds to produce a more functional engineered cartilage tissue construct than in free swelling controls. Compression bioreactors can improve glycosaminoglycan and hydroxyproline formation and increase the elastic modulus of the cartilage formed to approach that of native cartilage [136,137]. Meanwhile, Sittichockechaiwut et al [138] have shown that osteoblasts were highly sensitive to mechanical loading.…”

Section: Compression Bioreactormentioning

confidence: 99%

3D Bioprinting of Human Tissues: Biofabrication, Bioinks, and Bioreactors

Zhang

Wehrle

Rubert

et al. 2021

IJMS

114

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The field of tissue engineering has progressed tremendously over the past few decades in its ability to fabricate functional tissue substitutes for regenerative medicine and pharmaceutical research. Conventional scaffold-based approaches are limited in their capacity to produce constructs with the functionality and complexity of native tissue. Three-dimensional (3D) bioprinting offers exciting prospects for scaffolds fabrication, as it allows precise placement of cells, biochemical factors, and biomaterials in a layer-by-layer process. Compared with traditional scaffold fabrication approaches, 3D bioprinting is better to mimic the complex microstructures of biological tissues and accurately control the distribution of cells. Here, we describe recent technological advances in bio-fabrication focusing on 3D bioprinting processes for tissue engineering from data processing to bioprinting, mainly inkjet, laser, and extrusion-based technique. We then review the associated bioink formulation for 3D bioprinting of human tissues, including biomaterials, cells, and growth factors selection. The key bioink properties for successful bioprinting of human tissue were summarized. After bioprinting, the cells are generally devoid of any exposure to fluid mechanical cues, such as fluid shear stress, tension, and compression, which are crucial for tissue development and function in health and disease. The bioreactor can serve as a simulator to aid in the development of engineering human tissues from in vitro maturation of 3D cell-laden scaffolds. We then describe some of the most common bioreactors found in the engineering of several functional tissues, such as bone, cartilage, and cardiovascular applications. In the end, we conclude with a brief insight into present limitations and future developments on the application of 3D bioprinting and bioreactor systems for engineering human tissue.

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“…In the present study, the cortical bone was assumed as an orthotropic material while the cancellous bone was modelled as a linear isotropic material. The orthotropic materials do not have uniform mechanical properties in every direction [16]. While, isotropic materials have the same mechanical properties regardless of loading direction [17].…”

Section: Materials Propertiesmentioning

confidence: 99%

Numerical study of stress shielding evaluation of hip implant stems coated with composite (carbon/PEEK) and polymeric (PEEK) coating materials.

Darwich¹,

Nazha²,

Abbas³

2019

biomedicalresearch

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The forces applied to the prosthesis during human activity produce dynamic stresses varying in time and may causing stress shielding in prosthesis-bone system. Therefore, it is important to reduce stress shielding effect. This study aimed to investigates, using finite element analysis, how a PEEK and carbon/ PEEK composite coating materials on a titanium alloy hip implant stem could reduce stress shielding effect corresponding to different human activities: standing up, normal walking and climbing stairs under dynamic loadings to find out which of all these models have a better performance. A 3D finite element model of femur, hip implants, coating layers with composite (carbon/PEEK) and polymeric (PEEK) coating materials were constructed for finite element analysis. A time-dependent cycling load was applied on the prosthesis head. The maximum increase in load transfer to the bone was 207% for the prosthesis coated with carbon/PEEK configuration I (fibers orientated with 0, +45,-45, and 90 degrees) in average compared to uncoated one. Numerical result showed that the carbon/PEEK composite material (configuration I) seems to be a good solution to distribute the applied load and transfer it to the bone, thus to reduce stress shielding problems and to prolong lifetime of the prosthesisbone system. It will prevent aseptic loosening and enhance the stability of the system.

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A depth dependent transversely isotropic micromechanic model of articular cartilage

Cited by 8 publications

References 34 publications

Bioreactors for tissue engineering: An update

Bioreactors for tissue engineering: An update

3D Bioprinting of Human Tissues: Biofabrication, Bioinks, and Bioreactors

Numerical study of stress shielding evaluation of hip implant stems coated with composite (carbon/PEEK) and polymeric (PEEK) coating materials.

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