Tigecycline attenuates staphylococcal superantigen-induced T-cell proliferation and production of cytokines and chemokines

Saliba, Ranime; Paasch, Linda L.; Solh, Ali El

doi:10.3109/08923970902838672

Cited by 22 publications

(12 citation statements)

References 41 publications

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“…Staphylococcal enterotoxins (SEs) and TSST-1 are intermediate molecular weight proteins (20–30 kDa) that cause food poisoning and toxic syndrome, respectively, in humans and other species [5]. Moreover, both SEs and TSST-1 can act as bacterial superantigens that bind to MHC class II molecules on antigen presenting cells and selectively stimulate T cells expressing appropriate Vβ gene segments on their T cell receptors (TCRs) [6]. The secretion of staphylococcal exotoxins is regulated in a growth-phase-dependent manner, predominantly occurring during the post-exponential phase [7].…”

Section: Introductionmentioning

confidence: 99%

Subinhibitory Concentrations of Perilla Oil Affect the Expression of Secreted Virulence Factor Genes in Staphylococcus aureus

et al. 2011

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BackgroundThe pathogenicity of staphylococcus aureus is dependent largely upon its ability to secrete a number of virulence factors, therefore, anti-virulence strategy to combat S. aureus-mediated infections is now gaining great interest. It is widely recognized that some plant essential oils could affect the production of staphylococcal exotoxins when used at subinhibitory concentrations. Perilla [Perilla frutescens (L.) Britton], a natural medicine found in eastern Asia, is primarily used as both a medicinal and culinary herb. Its essential oil (perilla oil) has been previously demonstrated to be active against S. aureus. However, there are no data on the influence of perilla oil on the production of S. aureus exotoxins.Methodology/Principal FindingsA broth microdilution method was used to determine the minimum inhibitory concentrations (MICs) of perilla oil against S. aureus strains. Hemolysis, tumour necrosis factor (TNF) release, Western blot, and real-time RT-PCR assays were performed to evaluate the effects of subinhibitory concentrations of perilla oil on exotoxins production in S. aureus. The data presented here show that perilla oil dose-dependently decreased the production of α-toxin, enterotoxins A and B (the major staphylococcal enterotoxins), and toxic shock syndrome toxin 1 (TSST-1) in both methicillin-sensitive S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA).Conclusions/SignificanceThe production of α-toxin, SEA, SEB, and TSST-1 in S. aureus was decreased by perilla oil. These data suggest that perilla oil may be useful for the treatment of S. aureus infections when used in combination with β-lactam antibiotics, which can increase exotoxins production by S. aureus at subinhibitory concentrations. Furthermore, perilla oil could be rationally applied in food systems as a novel food preservative both to inhibit the growth of S. aureus and to repress the production of exotoxins, particularly staphylococcal enterotoxins.

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Section: Introductionmentioning

confidence: 99%

Subinhibitory Concentrations of Perilla Oil Affect the Expression of Secreted Virulence Factor Genes in Staphylococcus aureus

et al. 2011

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“…[ 36 ] As an acute-phase reactant, fibrinogen biosynthesis is increased by interleukin (IL)-6-mediated increases in the transcription of the fibrinogen mRNA [ 37 ] ; IL-1 and tumor necrosis factor-alpha suppress fibrinogen synthesis. [ 38 ] There is, however, room for speculation that tigecycline may interfere with the production of fibrinogen by influencing the level of cytokines or by directly influencing the transcription of fibrinogen mRNA.…”

Section: Discussionmentioning

confidence: 99%

Hypofibrinogenemia induced by high-dose tigecycline—case report and review of literature

Fan

Huang²,

Weng³

et al. 2020

Medicine

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Rationale: Extensive off-label use may affect the safety profile of tigecycline. Tigecycline-associated hypofibrinogenemia is potentially life threatening, although the frequency of life-threatening reactions is unknown and their incidence is easily overlooked. We report a case of 2 instances of treatment with high-dose tigecycline, each of which presented with hypofibrinogenemia. Patient concerns: An 86-year-old male patient was treated twice with high-dose tigecycline and presented with hypofibrinogenemia both times. The decrease in fibrinogen occurred within 3 to 7 days of tigecycline treatment. Other coagulation parameters had slightly prolonged values. Diagnoses: Coagulopathy and hypofibrinogenemia. Interventions: We discontinued the tigecycline. Outcomes: The fibrinogen level normalized within 5 days after the withdrawal of tigecycline. Following 80 days of hospitalization, the patient was transferred to the rehabilitation hospital for further treatment. Lessons: We suggest routine strict monitoring of coagulation parameters, particularly fibrinogen. Attention should be paid to below-normal fibrinogen levels due to increased bleeding risk and severity of reaction at fibrinogen levels below 1 g/L.

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“…Indeed, PMIN does not inhibit the growth of minocycline-sensitive bacterial strains (Lertvorachon et al 2005;Bastos et al 2008), but does inhibit licking behaviour in mice to the same extent as those induced by minocycline (Bastos et al 2008). On the other hand, tigecycline, which differs from minocycline by the long side chain at the 9 position of carbon atom (9-tert-butyl-glycylamido moiety) and broader antibacterial spectrum, inhibits the production of inflammatory cytokines in different experimental settings, and this effects are unrelated to the antibacterial activity (Saliba et al 2009;Salvatore et al 2009). Both PMIN and tigecycline are equipotent to minocycline in reducing the microglial production of PGE 2 induced by LPS (L.F.S.…”

Section: Interaction Between Minocycline and Morphinementioning

confidence: 97%

Tetracyclines and pain

Bastos

Oliveira

Watkins

et al. 2012

Naunyn-Schmiedeberg's Arch Pharmacol

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Tetracyclines are natural or semi-synthetic bacteriostatic agents which have been used since late 1940s against a wide range of gram-positive and gram-negative bacteria and atypical organisms such as chlamydia, mycoplasmas, rickettsia, and protozoan parasites. After the discovery of the first tetracyclines, a second generation of compounds was sought in order to improve water solubility for parenteral administration or to enhance bioavailability after oral administration. This approach resulted in the development of doxycycline and minocycline in the 1970s. Doxycycline was included in the World Health Organization Model List of Essential Medicines either as antibacterial or to prevent malaria or to treat patients with this disease. Additional development led to the third generation of tetracyclines, being tigecycline the only medicine of this class to date. Besides antibacterial activities, the anti-inflammatory, antihypernociceptive and neuroprotective activities of tetracyclines began to be widely studied in the late 1990s. Indeed, there has been an increasing interest in investigating the effects induced by minocycline as this liposoluble derivative is known to cross the blood-brain barrier to the greatest extent. Minocycline induces antihypernociceptive effects in a wide range of animal models of nociceptive, inflammatory and neuropathic pain. In this study, we discuss the antihypernociceptive activity of tetracyclines and summarise its underlying cellular and molecular mechanisms.

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Tigecycline attenuates staphylococcal superantigen-induced T-cell proliferation and production of cytokines and chemokines

Cited by 22 publications

References 41 publications

Subinhibitory Concentrations of Perilla Oil Affect the Expression of Secreted Virulence Factor Genes in Staphylococcus aureus

Subinhibitory Concentrations of Perilla Oil Affect the Expression of Secreted Virulence Factor Genes in Staphylococcus aureus

Hypofibrinogenemia induced by high-dose tigecycline—case report and review of literature

Tetracyclines and pain

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