Tierexperimentelle Thioacetamid-Leberschäden unter therapeutischen Sulfonylharnstoffgaben (D 860)

Knick, B; Ruckes, J; Emrich, K

doi:10.1007/bf02113450

Cited by 7 publications

(1 citation statement)

References 31 publications

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“…On the other hand, Muting [1956] (whose results and conclusions have, however, been criticized by Sfotter [1956] and Kühne & Schultz [1957]) found that prolonged treatment with carbutamide caused a slight decrease of the total serum proteins and a more marked one of serum albumin, as well as a slight increase of serum globulin; he suggested that these changes might possibly be due to early liver damage. Most authors agree that prolonged therapy with hypoglycaemic agents has no toxic effect on the liver parenchyma [Knick, Ruckes & Emrich, 1958;Fister, 1959]. Several investigators have observed no change in the level of serum proteins in diabetics after prolonged treatment with tolbutamide [Steigerwald, Schöffling, Pfeiffer & Meyer, 1957;Mohnike, Ulrich, Bibergeil & Czyzyk, 1957;Stich & Ehrhart, 1957].…”

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confidence: 99%

The Influence of Oral Hypoglycaemic Agents (Carbutamide and Tolbutamide) on the Serum Proteins of Normal Rats

Fišter¹,

Benas²

1960

Journal of Endocrinology

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The effect of prolonged administration of carbutamide and tolbutamide on serum proteins of normal rats has been investigated. Carbutamide, already known to produce an increase of thyroid weight and of serum cholesterol, caused disproteinaemia characterized by increase of total proteins and \g=a\1-globulin. Tolbutamide exerted no thyrostatic action and caused no changes in serum proteins. It is of interest that prolonged administration of water alone also induced an increase in \g=a\1-globulinbut, unlike carbutamide, a decrease in \g=g\-globulin. The changes of the serum proteins are discussed in relation to possible endocrine factors involved.

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confidence: 99%