Tick Tock

Gumz, Michelle L.

doi:10.1681/asn.2014020199

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…Kidney exhibits circadian rhythm of its function in both rodents and humans. The excretion of water and electrolyte and clearance of BUN and Cr from the blood are highly rhythmically regulated within the circadian time scale [ 176 , 177 ]. In addition, it was shown that IL-6 production is rhythmically regulated, which suggests that cisplatin nephrotoxicity might also depend on kidney sensitivity to diurnal variation in inflammatory reaction without direct cisplatin toxicity [ 175 ].…”

Section: Factors Modifying Cisplatin Nephrotoxicitymentioning

confidence: 99%

Cisplatin-Induced Rodent Model of Kidney Injury: Characteristics and Challenges

Perše

Večerić-Haler

2018

BioMed Research International

170

140

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Cisplatin is an antitumor drug used in the treatment of a wide variety of malignancies. However, its primary dose-limiting side effect is kidney injury, which is a major clinical concern. To help understand mechanisms involved in the development of kidney injury, cisplatin rodent model has been developed. Given the complex pathogenesis of kidney injury, which involves both local events in the kidney and interconnected and interdependent systemic effects in the body, cisplatin rodent model is indispensable in the investigation of underlying mechanisms and potential treatment strategies of both acute and chronic kidney injury. Cisplatin rodent model is well appreciated and widely used model due to its simplicity. It has many similarities to human cisplatin nephrotoxicity, which are mentioned in the paper. In spite of its simplicity and wide applicability, there are also traps that need to be taken into account when using cisplatin model. The present paper is aimed at giving a concise insight into the complex characteristics of cisplatin rodent model and heterogeneity of cisplatin dosage regimens as well as outlining factors that can severely influence the outcome of the model and the study. Challenges for future research are also mentioned.

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Section: Factors Modifying Cisplatin Nephrotoxicitymentioning

confidence: 99%

Cisplatin-Induced Rodent Model of Kidney Injury: Characteristics and Challenges

Perše

Večerić-Haler

2018

BioMed Research International

170

140

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“…With this in mind, there is an urgent need for research in order to clarify the biological consequences of sleep disturbance and fatigue among renal transplant patients. The influence of circadian rhythmicity on physiologic functions related to renal cells, including blood pressure control and homeostasis regulation, is a well-studied phenomenon [27,28,29,30]. Evidence suggests that reduced sleep duration and disturbed circadian rhythms may increase sympathetic nervous system stimulation, increase blood pressure, and impair metabolic regulation [31,32,33].…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Effects of Day-Time vs. Night-Time Surgery on Renal Transplant Patient Outcomes

Sugünes

Bichmann

Biernath

et al. 2019

JCM

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Sleep deprivation and disruption of the circadian rhythms could impair individual surgical performance and decision making. For this purpose, this study identified potential confounding factors on surgical renal transplant patient outcomes during day and night. Our retrospective cohort study of 215 adult renal cadaver transplant recipients, of which 132 recipients were allocated in the “day-time” group and 83 recipients in the “night-time” group, primarily stratified the patients into two cohorts, depending on the start time. Within a 24 h operational system, “day-time” was considered as being from 8 a.m. to 8 p.m. and “night-time” from 8 p.m. to 8 a.m.. Primary outcomes examined patient and graft survival after three months and one year. Secondary outcomes included the presence of acute rejection (AR) and delayed graft function (DGF), as well as the rate of postoperative complications. In log-rank testing, “day-time” surgery was associated with a significantly higher risk of patient death (p = 0.003), whereas long-term graft survival was unaffected by the operative time of day. The mean cold ischemia time (CIT), which was 12.4 ± 5.3 h in the “night-time” group, was significantly longer compared to 10.7 ± 3.6 for those during the day (p = 0.01). We observed that “night-time” kidney recipients experienced more wound complications. From our single-centre data, we conclude that night-time kidney transplantation does not increase the risk of adverse events or predispose the patient to a worse outcome. Nevertheless, further research is required to explore the effect of fatigue on nocturnal surgical performance.

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Chronobiology in nephrology: the influence of circadian rhythms on renal handling of drugs and renal disease treatment

Lavallaz

Musso

2018

Int Urol Nephrol

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Tick Tock

Cited by 4 publications

References 17 publications

Cisplatin-Induced Rodent Model of Kidney Injury: Characteristics and Challenges

Cisplatin-Induced Rodent Model of Kidney Injury: Characteristics and Challenges

Analysis of the Effects of Day-Time vs. Night-Time Surgery on Renal Transplant Patient Outcomes

Chronobiology in nephrology: the influence of circadian rhythms on renal handling of drugs and renal disease treatment

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