Chronobiology in nephrology: the influence of circadian rhythms on renal handling of drugs and renal disease treatment

Lavallaz, Lucas; Musso, Carlos G.

doi:10.1007/s11255-018-2001-z

Cited by 11 publications

(2 citation statements)

References 46 publications

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“…Chronopharmacology studies how biological rhythms influence pharmacokinetics, pharmacodynamics, and toxicity, and determines whether time-of-day administration modifies the pharmacological characteristics of the drug. Chronotherapy applies chronopharmacological studies to clinical treatments, determining the best biological time for dosing [101]. Well known examples in CKD patients include phosphate binders.…”

Section: The Way Forwardmentioning

confidence: 99%

Chronodisruption: A Poorly Recognized Feature of CKD

Carriazo

Ramos

Sanz

et al. 2020

Toxins

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Multiple physiological variables change over time in a predictable and repetitive manner, guided by molecular clocks that respond to external and internal clues and are coordinated by a central clock. The kidney is the site of one of the most active peripheral clocks. Biological rhythms, of which the best known are circadian rhythms, are required for normal physiology of the kidneys and other organs. Chronodisruption refers to the chronic disruption of circadian rhythms leading to disease. While there is evidence that circadian rhythms may be altered in kidney disease and that altered circadian rhythms may accelerate chronic kidney disease (CKD) progression, there is no comprehensive review on chronodisruption and chronodisruptors in CKD and its manifestations. Indeed, the term chronodisruption has been rarely applied to CKD despite chronodisruptors being potential therapeutic targets in CKD patients. We now discuss evidence for chronodisruption in CKD and the impact of chronodisruption on CKD manifestations, identify potential chronodisruptors, some of them uremic toxins, and their therapeutic implications, and discuss current unanswered questions on this topic.

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Section: The Way Forwardmentioning

confidence: 99%

Chronodisruption: A Poorly Recognized Feature of CKD

Carriazo

Ramos

Sanz

et al. 2020

Toxins

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“… 81 The rate of urine clearance of water-soluble drugs and their metabolites is associated with renal function, renal blood flow, glomerular filtration rate, the ability of the kidney to reabsorb or secrete drugs, urine flow, and urine pH, all of which have circadian behavior. 82 Mesial temporal lobe epilepsy is characterized by complex partial seizures originating from the hippocampus and is a common and refractory type of epilepsy. These types of spontaneous seizures show a dependency on the endogenous clock system for seizure threshold.…”

Section: Main Textmentioning

confidence: 99%

Overcoming Compensatory Mechanisms toward Chronic Drug Administration to Ensure Long-Term, Sustainable Beneficial Effects

Ilan

2020

Molecular Therapy - Methods & Clinical Development

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Chronic administration of drugs leads to the activation of compensatory mechanisms that may inhibit some of their activity and induce unwanted toxicity. These mechanisms are an obstacle for maintaining a sustainable effect for many chronic medications. Pathways that adapt to the burden induced by chronic drugs, whether or not related to the underlying disease, can lead to a partial or complete loss of effect. Variability characterizes many biological systems and manifests itself as large intra- and inter-individual differences in the response to drugs. Circadian rhythm-based chronotherapy is further associated with variability in responses noted among patients. This paper reviews current knowledge regarding the loss of effect of chronic medications and the range of variabilities that have been described in responses and loss of responses. Establishment of a personalized platform for overcoming these prohibitive mechanisms is presented as a model for ensuring long-term sustained medication effects. This novel platform implements personalized variability signatures and individualized circadian rhythms for preventing and opposing the prohibitive effect of the compensatory mechanisms induced by chronic drug administration.

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Chronobiology and Implications for Pharmacology

Gorman

2024

Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays

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Chronobiology in nephrology: the influence of circadian rhythms on renal handling of drugs and renal disease treatment

Cited by 11 publications

References 46 publications

Chronodisruption: A Poorly Recognized Feature of CKD

Chronodisruption: A Poorly Recognized Feature of CKD

Overcoming Compensatory Mechanisms toward Chronic Drug Administration to Ensure Long-Term, Sustainable Beneficial Effects

Chronobiology and Implications for Pharmacology

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