Tick-borne encephalitis

Lindquist, Lars

doi:10.1016/b978-0-444-53488-0.00025-0

Cited by 61 publications

(69 citation statements)

References 191 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For TBE, moderately raised CSF protein and mononuclear pleocytosis ranging from 6 × 10 6 to 1200 × 10 6 cells/l but normal glucose and lactate levels are characteristic . Exceptionally, TBE has been demonstrated without CSF pleocytosis .…”

Section: Clinical Characteristics and Diagnosismentioning

confidence: 99%

EAN consensus review on prevention, diagnosis and management of tick‐borne encephalitis

Taba

Schmutzhard

Forsberg

et al. 2017

Euro J of Neurology

164

185

View full text Add to dashboard Cite

show abstract

Section: Clinical Characteristics and Diagnosismentioning

confidence: 99%

EAN consensus review on prevention, diagnosis and management of tick‐borne encephalitis

Taba

Schmutzhard

Forsberg

et al. 2017

Euro J of Neurology

164

185

View full text Add to dashboard Cite

show abstract

“…Additionally, vasculitis and breakdown of the BBB was also observed following WNV infection [68]. Immune cell infiltration consisting of lymphocytes and macrophages in the brain stem, cerebellum and cortex is quite prominent following infection by tick-borne encephalitis virus (TBEV) and JEV [69,70]. Many focal areas of tissue necrosis can be found in JEV encephalitic brains, giving a “punched out” appearance.…”

Section: Encephalitismentioning

confidence: 99%

Viral diseases of the central nervous system

Swanson

McGavern

2015

Current Opinion in Virology

275

251

View full text Add to dashboard Cite

Virus-induced diseases of the central nervous system (CNS) represent a significant burden to human health worldwide. The complexity of these diseases is influenced by the sheer number of different neurotropic viruses, the diverse routes of CNS entry, viral tropism, and the immune system. Using a combination of human pathological data and experimental animal models, we have begun to uncover many of the mechanisms that viruses use to enter the CNS and cause disease. This review highlights a selection of neurotropic viruses that infect the CNS and explores the means by which they induce neurological diseases such as meningitis, encephalitis, and myelitis.

show abstract

“…Tick-borne encephalitis virus (TBEV) is the most important tick-transmitted virus causing human disease in Europe and Asia [1][2][3][4]. TBEV belongs to the genus Flavivirus, within the Flaviviridae family, and can be divided into three distinct subtypes: the European (TBEV-Eur, formerly known as Central European encephalitis virus), the Siberian (TBEV-Sib, formerly known as Siberian encephalitis virus), and the Far Eastern (TBEV-FE, formerly known as Russian Spring Summer encephalitis virus) subtypes [3]. Recently, two new subtypes of TBEV (Himalayan and Baikalian) have been characterised [5,6].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, two new subtypes of TBEV (Himalayan and Baikalian) have been characterised [5,6]. Several studies suggest that the case fatality rate for TBE caused by TBEV-Eur is 0-4% [1,7] by TBEV-Sib 2-3% [1,7] and by TBEV-FE 6-40% [1,3,7,8]. However, according to Ruzek et al, 2019 [9] the overall TBE mortality rate in Russia is approximately 2% (i.e.…”

Section: Introductionmentioning

confidence: 99%

Multi-laboratory evaluation of ReaScan TBE IgM rapid test, 2016 to 2017

et al. 2020

View full text Add to dashboard Cite

Background: Tick-borne encephalitis (TBE) is a potentially severe neurological disease caused by TBE virus (TBEV). In Europe and Asia, TBEV infection has become a growing public health concern and requires fast and specific detection. Aim: In this observational study, we evaluated a rapid TBE IgM test, ReaScan TBE, for usage in a clinical laboratory setting. Methods: Patient sera found negative or positive for TBEV by serological and/or molecular methods in diagnostic laboratories of five European countries endemic for TBEV (Estonia, Finland, Slovenia, the Netherlands and Sweden) were used to assess the sensitivity and specificity of the test. The patients' diagnoses were based on other commercial or quality assured in-house assays, i.e. each laboratory's conventional routine methods. For specificity analysis, serum samples from patients with infections known to cause problems in serology were employed. These samples tested positive for e.g. Epstein-Barr virus, cytomegalovirus and Anaplasma phagocytophilum, or for flaviviruses other than TBEV, i.e. dengue, Japanese encephalitis, West Nile and Zika viruses. Samples from individuals vaccinated against flaviviruses other than TBEV were also included. Altogether, 172 serum samples from patients with acute TBE and 306 TBE IgM negative samples were analysed. Results: Compared with each laboratory's conventional methods, the tested assay had similar sensitivity and specificity (99.4% and 97.7%, respectively). Samples containing potentially interfering antibodies did not cause specificity problems. Conclusion: Regarding diagnosis of acute TBEV infections, ReaScan TBE offers rapid and convenient complementary IgM detection. If used as a stand-alone, it can provide preliminary results in a laboratory or point of care setting.

show abstract

Tick-borne encephalitis

Cited by 61 publications

References 191 publications

EAN consensus review on prevention, diagnosis and management of tick‐borne encephalitis

EAN consensus review on prevention, diagnosis and management of tick‐borne encephalitis

Viral diseases of the central nervous system

Multi-laboratory evaluation of ReaScan TBE IgM rapid test, 2016 to 2017

Contact Info

Product

Resources

About