Tibolone: the way to beat many a postmenopausal ailments

Lazovic, Gordana; Radivojevic, Ubavka; Marinković, Jelena

doi:10.1517/14656566.9.6.1039

Cited by 8 publications

(2 citation statements)

References 75 publications

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“…Tibolone is used for the treatment of menopausal symptoms and for the postponement and calming of symptoms accompanying agerelated diseases (72). A case of a patient under tibolone therapy for 2 years who developed a mixed-type liver injury with prolonged cholestasis and features of the vanishing bile duct syndrome following a 10-week treatment with SJW has been reported (73).…”

Section: Hormonal Therapymentioning

confidence: 99%

Herb–Drug Interactions with St John’s Wort (Hypericum perforatum): an Update on Clinical Observations

Borrelli

Izzo

2009

AAPS J

236

190

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Abstract. St John's wort (SJW) extracts, prepared from the aerial parts of Hypericum perforatum, contain numerous pharmacologically active ingredients, including naphthodianthrones (e.g., hypericin and its derivatives), phloroglucinols derivatives (e.g., hyperforin, which inhibits the reuptake of a number of neurotransmitters, including serotonin), and flavonoids. Such extracts are widely used for the treatment of mild-to-moderate depression. As a monotherapy, SJW has an encouraging safety profile. However, relevant and, in some case, life-threatening interactions have been reported, particularly with drugs which are substrate of cytochrome P450 and/or P-glycoprotein. Well-documented SJW interactions include (1) reduced blood cyclosporin concentration, as suggested by multiple case reports as well as by clinical trials, (2) serotonin syndrome or lethargy when SJW was given with serotonin reuptake inhibitors, (3) unwanted pregnancies in women while using oral contraceptives and SJW, and (4) reduced plasma drug concentration of antiretroviral (e.g., indinavir, nevirapine) and anticancer (i.e., irinotecan, imatinib) drugs. Hyperforin, which is believed to contribute to the antidepressant action of St John's wort, is also strongly suspected to be responsible of most of the described interactions.

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Section: Hormonal Therapymentioning

confidence: 99%

Herb–Drug Interactions with St John’s Wort (Hypericum perforatum): an Update on Clinical Observations

Borrelli

Izzo

2009

AAPS J

236

190

View full text Add to dashboard Cite

show abstract

“…Tibolone is a synthetic compound with mixed oestrogenic, progestogenic and androgenic activities, representing an alternative to conventional HRT (Lazovic et al, 2008). It represents an efficient option for vasomotor symptoms alleviation or prevention of BMD loss in menopausal women (Gallagher et al, 2001;Swanson et al, 2006).…”

Section: Other Therapeutic Optionsmentioning

confidence: 99%