Pharmacology of Hormone Replacement Therapy in Menopause

Voican, A.; Francou, Bruno; Novac, Liliana; Chabbert-Buffet, Nathalie; Canonico, Marianne; Meduri, Géri; Lombès, Marc; Scarabin, Pierre‐Yves; Young, Jacques; Guiochon‐Mantel, Anne; Bouligand, Jérôme

doi:10.5772/32655

Cited by 3 publications

(6 citation statements)

References 147 publications

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“…As a result of the lack of intestinal and first-pass hepatic metabolism, a different profile of intermediate metabolites is seen. 13 Specifically, the estrone to estradiol ratio is closer to 1:1 with the transdermal route, which mimics the physiologic ratio seen in premenopausal women. [14][15][16] These effects are summarized in Figure 1.…”

Section: Transdermal Estradiol Delivery Systems: Characteristics and mentioning

confidence: 80%

Clinical efficacy of estradiol transdermal system in the treatment of hot flashes in postmenopausal women

Castelo-Branco¹,

Soveral²

2014

RRTD

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Hot flashes are among the most common symptoms of estrogen deprivation associated with menopause. Hot flashes affect quality of life in menopausal women and constitute the main indication for hormonal replacement. Treatment using estrogens with or without a progestin is highly effective in reducing the frequency and intensity of hot flashes. There are several estrogen formulations available for the treatment of menopausal symptoms, including oral, transdermal, intranasal, and vaginal preparations. Within the transdermal group, several preparations exist and all have been shown to be effective in the control of hot flashes. Transdermal estrogens constitute an effective treatment for menopausal hot flashes and may have additional beneficial effects compared with oral treatment, given that first-pass hepatic metabolism is avoided using the transdermal route. Transdermal estrogens should be considered as a viable treatment option for symptomatic menopausal women. When it has been decided to use the transdermal route, the woman should be informed of the benefits and side effects of each transdermal system and her preference taken into account when recommending a specific transdermal preparation.

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Section: Transdermal Estradiol Delivery Systems: Characteristics and mentioning

confidence: 80%

Clinical efficacy of estradiol transdermal system in the treatment of hot flashes in postmenopausal women

Castelo-Branco¹,

Soveral²

2014

RRTD

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“…Thus, in the egg-type chickens, the greatest body weight gain was ob-served in the decades II and III [8] that agrees with our data (see Table 1). The cholesterol donation detected at the age of 42 days (see Table 2) (r-Pearson: LDL and TCS -r = 0.86, p = 0.002) apparently provides an endocrine pool for the synthesis of progesterone and its derivatives [15,16,25] (see Table 1, 2, Fig.). It was reported [8] that in white Leghorn cross chicks the growth stabilized after 30 days of life.…”

Section: Factor Analysis With Principal Component Methods Of Blood Biomentioning

confidence: 99%

“…), particularly, the vascular ones. The events involve intracellular nuclear receptors [14] and the so-called extragenome integral membrane progesterone receptors [14,15], involved in express responses not accompanied by gene transcription [14,15], and, apparently, being necessary in growth and development.…”

Section: Factor Analysis With Principal Component Methods Of Blood Biomentioning

confidence: 99%

“…Recent studies have established that progesterone and its synthetic derivatives have a direct, due to the neurosteroids of the group of pregnenolone synthesized de novo from cholesterol in the brain of birds [12], and mediated [13,14] effects on the vegetative and central nervous system. They also participate in the neurotransmitter control over the chronological rhythms of postnatal growth and development due to receptor interaction with aminobutyric acid [12,13] and dopamine, affect the organogenesis of blood vessels, locomotor apparatus [15], skeletal muscles (which has hypertrophic development in broiler chickens) [5,9], and myelination of nerve fibers [13]. Progesterone, 17-hydroxyprogesterone and its metabolite cortisol are among the primary activators and effectors of the hypothalamic-pituitary-adrenal axis [10,16].…”

mentioning

confidence: 99%

“…On day 7, the broilers showed a factor (see Table 2, Fig. ) which included progesterone and cortisol as principal components (r-Pearson: P 4 and Cortisol -r = 0.73, p = 0.016), and also a factor of cholesterol donation through active conversion of LDL cholesterol to progesterone and, therefore, the activation of endocrine metabolic pathway of 17-OHP and its products, the sex hormones, cortisol and other steroids [15,16] (see Table 1, 2, Fig.). Progesterone (along with somatotropic and thyroid hormones) provides an increase in body weight, primarily due to the regulation of the synthesis of proteins (mainly the proteins of skeletal muscles and tissues of internal organs) [24].…”

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confidence: 99%

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Involvement of Cholesterol, Progesterone, Cortisol and Lipoproteins in Metabolic Changes During Early Ontogenesis of Broiler Chicks of an Industrial Cross

Kolesnik¹,

Дерхо²

2017

S-h. biol.

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Morphophysiological changes in body are influenced by environmental factors, what is more, the specific nature of the body reactions depends on the reaction rate and the stage of ontogenesis on which the physiological stimuli act (I. Schmalhausen, 1982). Also it is known that hormones participate in the regulation of metabolism, growth and development, in adaptation processes. We determined the concentration of high-density (HDL) and low density (LDL) lipoproteins directly involved in protein and lipid metabolism, total cholesterol (TCS), progesterone (P 4), 17hydroxyprogesterone (17-OHP), and cortisol in blood plasma of Hubbard F15 broiler chickens at early postnatal ontogenesis using four groups of poultry of the industrial herd of Chebarkulskaya Ptitsa LLC (Chelyabinsk Province, Russian Federation), 10 animals in each, aged 1, 7, 23 and 42 days, respectively. The role and interrelations of these substances in metabolism were assessed using Pearson's correlation analysis and factor analysis by the principal components method with Varimax factor rotation. Thus, in 1-day aged chicks, the integration of factors HDL, LDL, TCS, P 4 and cortisol involved in metabolic processes and metabolism regulations was noted with r-Pearson for P 4

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Ovarian Tissue-Based Hormone Replacement Therapy Recovers Menopause-Related Signs in Mice

et al. 2022

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Purpose In women, menopause manifests with a variety of symptoms related to sex-hormone deficiency. Supplementing steroid hormones with pharmacological drugs has been widely practiced. However, considering the possible complications associated with artificial hormone therapy, studies have been conducted to find an alternative to pharmacological hormone replacement therapy. Accordingly, this study aimed to evaluate the efficacy of tissue-based hormone replacement therapy (tHRT) for treating post-menopausal signs and symptoms. Materials and Methods CD-1 mice were ovariectomized, and the ovaries were cryopreserved. Following artificial induction of post-menopausal osteoporosis, cryopreserved ovaries were subcutaneously autografted, and indexes related to bone health were monitored for 12 weeks. Bone mineral density (BMD), bone mineral contents (BMC), total bone volume (BV), and body fat mass were measured by dual energy X-ray absorptiometry. Uterine atrophy was assessed histologically, and bone microstructures were imaged by micro-computed tomography analysis. Results Regardless of the number of grafted ovaries, the BMC, BMD, and BV values of mice that underwent ovary transplantation were better than those that did not undergo transplantation. The uteruses in these mice were thicker and heavier after auto-transplantation. Furthermore, the bone microstructure recovered after tHRT. Conclusion Recovery of menopause-related bone loss and uterine atrophy was achieved through tHRT. Ovarian tissue cryopreservation and transplantation may be applicable not only in patients wanting to preserve fertility but also in sex hormone-deficient post-menopausal women.

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Pharmacology of Hormone Replacement Therapy in Menopause

Cited by 3 publications

References 147 publications

Clinical efficacy of estradiol transdermal system in the treatment of hot flashes in postmenopausal women

Clinical efficacy of estradiol transdermal system in the treatment of hot flashes in postmenopausal women

Involvement of Cholesterol, Progesterone, Cortisol and Lipoproteins in Metabolic Changes During Early Ontogenesis of Broiler Chicks of an Industrial Cross

Ovarian Tissue-Based Hormone Replacement Therapy Recovers Menopause-Related Signs in Mice

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