Tiamulin in the Feed for the Prevention of Swine Dysentery and Growth Promotion of Growing Pigs

O’Connor, John; Baughn, Caroline; Pilote, R. R.; Alpaugh, W. C.; Linkenheimer, W. H.; Maplesden, D. C.

doi:10.2527/jas1979.494933x

Cited by 4 publications

(3 citation statements)

References 3 publications

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“…Tiamulin is a pleuromutilin antibiotic fed to reduce swine dysentery caused by Brachyspira ( Treponema ) hyodysenteriae (O'Connor et al . ; van Duijkeren et al . ).…”

Section: Discussionmentioning

confidence: 99%

“…Chlortetracycline is a tetracycline derivative with broad-spectrum antimicrobial activity commonly used in swine production but may have little effect against Campylobacter since most isolates harbour resistance (Quintana-Hayashi and Thakur 2012). Tiamulin is a pleuromutilin antibiotic fed to reduce swine dysentery caused by Brachyspira (Treponema) hyodysenteriae (O'Connor et al 1979;van Duijkeren et al 2014). Resistance against tiamulin is not widespread but Campylobacter appears to harbour resistance (Lykkegberg et al 2007).…”

Section: Discussionmentioning

confidence: 99%

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Effect of lysozyme or antibiotics on faecal zoonotic pathogens in nursery pigs

et al. 2015

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“…Tiamulin is a pleuromutilin antibiotic fed to reduce swine dysentery caused by Brachyspira ( Treponema ) hyodysenteriae (O'Connor et al . ; van Duijkeren et al . ).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of lysozyme or antibiotics on faecal zoonotic pathogens in nursery pigs

et al. 2015

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“…Tiamulin was approved for use in veterinary medicine in 1979, followed by valnemulin in 1999. Retapamulin was the only pleuromutilin approved for topical use for humans since 2007 (Novak, 2011). However, in 2019, the U.S. Food and Drug Administration approved lefamulin, a newly developed pleuromutilin, to treat adults with community-acquired bacterial pneumonia due to its activity against Staphylococcus aureus, Streptococcus pneumoniae and atypical bacteria (Andrei et al, 2019;WHO, 2021;Zhanel et al, 2021).…”

Section: Short Description Of the Class/substancementioning

confidence: 99%

Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 8: Pleuromutilins: tiamulin and valnemulin

Koutsoumanis¹,

Allende²,

Álvarez‐Ordóñez³

et al. 2021

EFS2

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The specific concentrations of tiamulin and valnemulin in non-target feed for food-producing animals, below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial concentrations in feed which have an effect in terms of growth promotion/increased yield were assessed by EFSA in collaboration with EMA. Details of the methodology used for this assessment, associated data gaps and uncertainties, are presented in a separate document. To address antimicrobial resistance, the Feed Antimicrobial Resistance Selection Concentration (FARSC) model developed specifically for the assessment was applied. However, due to the lack of data on the parameters required to calculate the FARSC, it was not possible to conclude the assessment until further experimental data become available. To address growth promotion, data from scientific publications obtained from an extensive literature review were used. Levels in feed that showed to have an effect on growth promotion/ increased yield were reported for tiamulin, while for valnemulin no suitable data for the assessment were available. It was recommended to carry out studies to generate the data that are required to fill the gaps which prevented the calculation of the FARSC for these two antimicrobials.

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Design, synthesis, and evaluation of novel pleuromutilin aryl acrylate derivatives as promising broad-spectrum antibiotics especially for combatting multi-drug resistant gram-negative bacteria

et al. 2023

European Journal of Medicinal Chemistry

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Tiamulin in the Feed for the Prevention of Swine Dysentery and Growth Promotion of Growing Pigs

Cited by 4 publications

References 3 publications

Effect of lysozyme or antibiotics on faecal zoonotic pathogens in nursery pigs

Effect of lysozyme or antibiotics on faecal zoonotic pathogens in nursery pigs

Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 8: Pleuromutilins: tiamulin and valnemulin

Design, synthesis, and evaluation of novel pleuromutilin aryl acrylate derivatives as promising broad-spectrum antibiotics especially for combatting multi-drug resistant gram-negative bacteria

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