Ti–O based nanomaterials ameliorate experimental autoimmune encephalomyelitis and collagen-induced arthritis

Abstract

Administration of Ti–O based nanomaterials ameliorated the clinical severity of experimental autoimmune encephalomyelitis and collagen induced arthritis, thus provide novel therapeutic approach for multiple sclerosis and rheumatoid arthritis.

Green Synthesis of Silver Nanoparticles and Evaluation of Their Antibacterial Activity against Multidrug-Resistant Bacteria and Wound Healing Efficacy Using a Murine Model

“…The use of nanomedicines has increased enormously, and nanomaterials have been shown to offer promising strategies to optimize and improve the treatment of numerous disorders, including burns and wounds, owing to their unique small size, large surface area, and large surface-to-volume ratio. Hence, nanoparticles are considered magic bullets that are used in fundamental tasks in science, medicine, and different biotechnological fields, including imaging, biosensors, targeted drug delivery, and disease therapy [ 1 , 2 ]. More importantly, nanoparticles have played a role in delivering drugs, light, heat, and many substances to specific cancer cells in several biological applications.…”

Immunotherapeutic nanoparticles: From autoimmune disease control to the development of vaccines

“…TiO 2 nanotubes, NPs or fine particles have been described to diminish splenocytes proliferation (~20-35%) in concentrations of 50 μg/ml for NPs and nanotubes or 100 μg/ml for fine particles. These authors also found lower levels of IL-2 and INF-γ in a mix lymphocyte reaction assay, probably by blocking Th-1 cell (T cells that lead to an increased cell-mediated response, typically directed against intracellular bacteria and protozoa) response in vitro [94]. The importance of this finding resides in the fact that low levels of IL-2 maintain Tregs cells activity, preventing autoimmune diseases.…”

“…This molecule, a Th-2 cytokine, induces the production of IgE and mast cell activation, both implicated in allergies diseases. Other work of the same authors, described that TiO 2 NPs ameliorate EAE and collagen induced arthritis [94]. On the other hand, it was described that oral consumption of TiO 2 NPs increase cytokines levels and the presence of pro-inflammatory immune cells in the colonic mucosa, indicating an inflammatory state [95,96].…”

Immunomodulatory properties of titanium dioxide nanostructural materials

“…[ 13 ] Recently, we showed that TiO 2 -based nanomaterials ameliorate experimental autoimmune encephalomyelitis and collagen-induced arthritis and demonstrated that lowering HMGB1 levels is possible mechanism for this amelioration. [ 14 ]…”

“…Our findings suggest that TiO 2 nanomaterials suppressed splenocytes proliferation by reducing IL-2 and IFNγ cytokine levels in MLR cultures. Based on our published data [ 14 ] and current suppression and cytokine data, we hypothesized that TiO 2 nanomaterials may lower the immune responses and could be useful for the treatment of graft versus host diseases and autoimmune disorders.…”