Immunomodulatory properties of titanium dioxide nanostructural materials

Latha, T. Sree; Reddy, Madhava C.; Durbaka, Prasad V. R.; Muthukonda, Shankar V.; Lomada, Dakshayani

doi:10.4103/ijp.ijp_536_16

Cited by 14 publications

(10 citation statements)

References 15 publications

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“…Modifying material properties may decrease the immune response to implanted biomaterial [ 102 ]. In this sense, it is known that the modification of implant surfaces with titanium oxide (TiO2) nanotubes positively affect the osseointegration, probably by switching the phenotype of peri-implant macrophages from the pro-inflammatory (M1) subset to a pro-regenerative one (M2) [ [104] , [105] , [106] , [107] , [108] , [109] ] ( Fig. 2 A).…”

Section: Strategies To Modulate the Peri-implant Immune Component To mentioning

confidence: 99%

Osteoimmunology drives dental implant osseointegration: A new paradigm for implant dentistry

Amengual‐Peñafiel

Córdova

Jara-Sepúlveda

et al. 2021

Japanese Dental Science Review

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There is a complex interaction between titanium dental implants, bone, and the immune system. Among them, specific immune cells, macrophages play a crucial role in the osseointegration dynamics. Infiltrating macrophages and resident macrophages (osteomacs) contribute to achieving an early pro-regenerative peri-implant environment. Also, multinucleated giant cells (MNGCs) in the bone-implant interface and their polarization ability, maintain a peri-implant immunological balance to preserve osseointegration integrity. However, dental implants can display cumulative levels of antigens (ions, nano and microparticles and bacterial antigens) at the implant–tissue interface activating an immune-inflammatory response. If the inflammation is not resolved or reactivated due to the stress signals and the immunogenicity of elements present, this could lead implants to aseptic loosening, infections, and subsequent bone loss. Therefore, to maintain osseointegration and prevent bone loss of implants, a better understanding of the osteoimmunology of the peri-implant environment would lead to the development of new therapeutic approaches. In this line, depicting osteoimmunological mechanisms, we discuss immunomodulatory strategies to improve and preserve a long-term functional integration between dental implants and the human body. Scientific field of dental science: implant dentistry.

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Section: Strategies To Modulate the Peri-implant Immune Component To mentioning

confidence: 99%

Osteoimmunology drives dental implant osseointegration: A new paradigm for implant dentistry

Amengual‐Peñafiel

Córdova

Jara-Sepúlveda

et al. 2021

Japanese Dental Science Review

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“…ID: “Our data suggest that TiO2 nanostructural materials suppress splenocytes proliferation by suppressing Th1 cytokines.” [ 181 ]…”

Section: Commonality Of Contributing Factors Between Ibd and Id - Detailsmentioning

confidence: 99%

Common contributing factors to COVID-19 and inflammatory bowel disease

Kostoff

Briggs²,

Kanduc

et al. 2021

Toxicology Reports

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“…Titanium dioxide NPs (TiO 2 NPs) have a safe profile and are nontoxic to mammalian cells as they are chemically inert and stable under physiological conditions [ 161 , 162 , 163 ]. This biocompatibility has attracted great interest and has made it possible for its use in numerous applications, ranging from pigments in paints, toothpaste, the absorption of ultraviolet light in sunscreen lotions, food additives, and—recently—agriculture and biomedicine [ 164 ].…”

Section: To the Metals!mentioning

confidence: 99%

Prospects for the Use of Metal-Based Nanoparticles as Adjuvants for Local Cancer Immunotherapy

et al. 2023

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Immunotherapy is among the most effective approaches for treating cancer. One of the key aspects for successful immunotherapy is to achieve a strong and stable antitumor immune response. Modern immune checkpoint therapy demonstrates that cancer can be defeated. However, it also points out the weaknesses of immunotherapy, as not all tumors respond to therapy and the co-administration of different immunomodulators may be severely limited due to their systemic toxicity. Nevertheless, there is an established way through which to increase the immunogenicity of immunotherapy—by the use of adjuvants. These enhance the immune response without inducing such severe adverse effects. One of the most well-known and studied adjuvant strategies to improve immunotherapy efficacy is the use of metal-based compounds, in more modern implementation—metal-based nanoparticles (MNPs), which are exogenous agents that act as danger signals. Adding innate immune activation to the main action of an immunomodulator makes it capable of eliciting a robust anti-cancer immune response. The use of an adjuvant has the peculiarity of a local administration of the drug, which positively affects its safety. In this review, we will consider the use of MNPs as low-toxicity adjuvants for cancer immunotherapy, which could provide an abscopal effect when administered locally.

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Immunomodulatory properties of titanium dioxide nanostructural materials

Cited by 14 publications

References 15 publications

Osteoimmunology drives dental implant osseointegration: A new paradigm for implant dentistry

Osteoimmunology drives dental implant osseointegration: A new paradigm for implant dentistry

Common contributing factors to COVID-19 and inflammatory bowel disease

Prospects for the Use of Metal-Based Nanoparticles as Adjuvants for Local Cancer Immunotherapy

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