Thyroxine treatment modified in infertile women according to thyroxine-releasing hormone testing: 5 year follow-up of 283 women referred after exclusion of absolute causes of infertility

Raber, Wolfgang; Nowotny, Peter; Vytiska-Binstorfer, E; Vierhapper, H.

doi:10.1093/humrep/deg142

Cited by 65 publications

(62 citation statements)

References 46 publications

(63 reference statements)

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“…subclinical hypothyroidism. 10 Abalovich et al studied 244 infertile women and observed a higher prevalence of subclinical hypothyroidism (13.9%) in patients with infertility.…”

Section: Comparison Of Prevalence Of Abnormal Thyroid Function In Infmentioning

confidence: 99%

Role of thyroid dysfunction and thyroid autoimmunity in infertile women: study done in 450 bedded maternity hospital of Delhi, India

Gupta¹,

Bansal²,

Ajmani³

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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Background: the aim was to study the prevalence of abnormal thyroid function and thyroid autoimmunity in infertile women and in general population (control group) and to correlate the thyroid dysfunction with presence of anti-thyroid antibodies. It was a case control study. The study was carried out at Department of obstetrics and gynaecology, Kasturba Hospital, Delhi. Population of the study was fifty infertile women in whom other causes of infertility are excluded and fifty fertile women attending out- patient department with other complaints.Methods: All the women enrolled in the study were non pregnant, clinically euthyroid (with no signs and symptoms of thyroid disorders and no documented abnormal thyroid function test) and no known autoimmune disorder. Detailed history and a thorough general physical examination, including thyroid examination was done. Haemogram, blood group, fasting and post prandial blood sugar, VDRL, transabdominal ultrasound, TSH, free T3, free T4, and antithyroid per-oxidase antibody assay was done using the ELISA technique.Results: The mean age of the study group was found 28.38±2.45 years, 22% had abnormal thyroid function, 20% had antithyroid antibodies positive and the mean TSH of the study group was 4.61±1.72µIU/ml. The mean age of the control group was found to be 29.10±2.01 years, 12% had abnormal thyroid function, 10% had antithyroid antibodies positive and the mean TSH of the control group was 3.89±1.56µIU/ml.Conclusions: Thyroid dysfunction and anti-thyroid antibodies were more prevalent in patients with infertility. A statistically significant correlation was established between thyroid autoimmunity and thyroid dysfunction in infertile women in the study.

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“…subclinical hypothyroidism. 10 Abalovich et al studied 244 infertile women and observed a higher prevalence of subclinical hypothyroidism (13.9%) in patients with infertility.…”

Section: Comparison Of Prevalence Of Abnormal Thyroid Function In Infmentioning

confidence: 99%

Role of thyroid dysfunction and thyroid autoimmunity in infertile women: study done in 450 bedded maternity hospital of Delhi, India

Gupta¹,

Bansal²,

Ajmani³

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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“…Alteration in thyroid function, particularly hypothyroidism, can cause ovulatory dysfunction, the latter being the leading cause of impaired female fertility 1–3. Although the underlying causes of hypothyroidism and polycystic ovary syndrome (PCOS) are completely different, these two entities have many features in common, including oligo- or anovulation; decreased serum sex hormone–binding globulin; increased serum free testosterone, luteinizing hormone (LH) and cholesterol concentrations 4–7.…”

mentioning

confidence: 99%

Effect of thyroid hormone replacement therapy on ovarian volume and androgen hormones in patients with untreated primary hypothyroidism

Müderris

Boztosun

Öner

et al. 2011

Annals of Saudi Medicine

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BACKGROUND AND OBJECTIVES:Primary hypothyroidism may be associated with ovarian enlargement and/ or cyst formation. We evaluated the effect of thyroid hormone replacement therapy on hormonal changes, ovarian volume and sonographic appearance.DESIGN AND SETTING:Open, prospective study of women admitted to university gynecology clinic.PATIENTS AND METHODS:The study included 26 patients with untreated hypothyroidism who had polycystic (n=10) or normal-appearing (n=16) ovaries and 20 euthyroidic controls. Basal serum total testosterone, free testosterone, androstenedione, dehydroepiandosterone-sulfate, prolactin, estradiol, luteinizing hormone, follicle-stimulating hormone, free T3, free T4 and thyroid-stimulating horone, together with ovarian volumes, were determined and repeated after euthyroidism was achieved.RESULTS:Ovarian volumes of patients with hypothyroidism were significantly greater compared with controls, and their magnitudes diminished significantly during thyroid hormone replacement therapy. Hypothyroidic patients with polycystic ovaries had significantly higher serum free testosterone and dehydroepiandosterone-sulfate, but lower androstenodione levels compared with those who had normal-appearing ovaries. Serum total testosterone concentrations were significantly higher in hypothyroidic patients without polycystic ovaries, and thyroid hormone replacement therapy achieved a significant reduction in total as well as free testosterone.CONCLUSION:Severe longstanding hypothyroidism leads to increased ovarian volume and/or cyst formation. A decrease in ovarian volume, resolution of ovarian cysts and reversal of the polycystic ovary syndrome-like appearance, together with improvement in serum hormone levels, occurred after euthyroidism was achieved.

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“…In a controlled prospective study of 438 women with infertility of various origin, the median TSH levels were significantly higher than controls (Poppe et al, 2002). Moreover more frequent miscarriages were observed in women with higher basal TSH levels, irrespective of the presence of AITD (Raber et al, 2003).…”

Section: Hypothyroidism and Female Infertilitymentioning

confidence: 88%

Hypothyroidism, Oxidative Stress and Reproduction

Mancini¹,

Giacchi²,

Raimondo³

et al. 2012

Hypothyroidism - Influences and Treatments

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Thyroxine treatment modified in infertile women according to thyroxine-releasing hormone testing: 5 year follow-up of 283 women referred after exclusion of absolute causes of infertility

Abstract: Based on the presented protocol, high pregnancy and parturition rates were observed. Whether this is due to early T4 therapy remains to be determined. Abortions appeared to be associated with higher TSH but not with elevated thyroid antibodies.

Cited by 65 publications

References 46 publications

Role of thyroid dysfunction and thyroid autoimmunity in infertile women: study done in 450 bedded maternity hospital of Delhi, India

Role of thyroid dysfunction and thyroid autoimmunity in infertile women: study done in 450 bedded maternity hospital of Delhi, India

Effect of thyroid hormone replacement therapy on ovarian volume and androgen hormones in patients with untreated primary hypothyroidism

Hypothyroidism, Oxidative Stress and Reproduction

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