Hypothyroidism, Oxidative Stress and Reproduction

Mancini, Antonio; Giacchi, E.; Raimondo, Sebastiano; Segni, Chantal Di; Silvestrini, Andrea; Meucci, Elisabetta

doi:10.5772/31939

Cited by 8 publications

(6 citation statements)

References 93 publications

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“…The role of thyroid in the regulation of the antioxidant systems has been recently reviewed in the context of the reproductive endocrinology [ 41 ]. It is well known that thyroid function influences the ovarian activity.…”

Section: The Role Of Thyroid Hormones In Antioxidant Regulationmentioning

confidence: 99%

Thyroid Hormones, Oxidative Stress, and Inflammation

Mancini

Segni

Raimondo

et al. 2016

Mediators of Inflammation

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357

254

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Inflammation and oxidative stress (OS) are closely related processes, as well exemplified in obesity and cardiovascular diseases. OS is also related to hormonal derangement in a reciprocal way. Among the various hormonal influences that operate on the antioxidant balance, thyroid hormones play particularly important roles, since both hyperthyroidism and hypothyroidism have been shown to be associated with OS in animals and humans. In this context, the nonthyroidal illness syndrome (NTIS) that typically manifests as reduced conversion of thyroxine (T4) to triiodothyronine (T3) in different acute and chronic systemic conditions is still a debated topic. The pathophysiological mechanisms of this syndrome are reviewed, together with the roles of deiodinases, the enzymes responsible for the conversion of T4 to T3, in both physiological and pathological situations. The presence of OS indexes in NTIS supports the hypothesis that it represents a condition of hypothyroidism at the tissue level and not only an adaptive mechanism to diseases.

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Section: The Role Of Thyroid Hormones In Antioxidant Regulationmentioning

confidence: 99%

Thyroid Hormones, Oxidative Stress, and Inflammation

Mancini

Segni

Raimondo

et al. 2016

Mediators of Inflammation

Self Cite

357

254

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“…However, increasing evidences have highlighted that ROS are not just harmful agents implicated in the pathogenesis of various disorders and diseases. ROS can also act as mobile redox messengers in the regulation of numerous signaling pathways ranging from cell homeostasis to cell death [19,20] as reported in the ovarian physiology, as we previously reviewed [21]. Consequently, the idea that "ROS are unfavorable, and antioxidants are favorable" has undergone a critical and considerable reappraisal.…”

Section: Introductionmentioning

confidence: 92%

Oxidative Stress and Low-Grade Inflammation in Polycystic Ovary Syndrome: Controversies and New Insights

Mancini

Bruno

Vergani

et al. 2021

IJMS

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The pathophysiology of Polycystic Ovary Syndrome (PCOS) is quite complex and different mechanisms could contribute to hyperandrogenism and anovulation, which are the main features of the syndrome. Obesity and insulin-resistance are claimed as the principal factors contributing to the clinical presentation; in normal weight PCOS either, increased visceral adipose tissue has been described. However, their role is still debated, as debated are the biochemical markers linked to obesity per se. Oxidative stress (OS) and low-grade inflammation (LGI) have recently been a matter of researcher attention; they can influence each other in a reciprocal vicious cycle. In this review, we summarize the main mechanism of radical generation and the link with LGI. Furthermore, we discuss papers in favor or against the role of obesity as the first pathogenetic factor, and show how OS itself, on the contrary, can induce obesity and insulin resistance; in particular, the role of GH-IGF-1 axis is highlighted. Finally, the possible consequences on vitamin D synthesis and activation on the immune system are briefly discussed. This review intends to underline the key role of oxidative stress and low-grade inflammation in the physiopathology of PCOS, they can cause or worsen obesity, insulin-resistance, vitamin D deficiency, and immune dyscrasia, suggesting an inverse interaction to what is usually considered.

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“…How is Frankincense attributed to memory? One of the main target sites of thyroid hormone deficiency and its resulting oxidative stress is the brain and nerve system from the fetal until adulthood period of human beings (Kobayashi et al, 2005;Mancini et al, 2012;Vallortigara, Alfos, Micheau, Higueret, & Enderlin, 2008).…”

Section: Memory-boosting Effects Of Frankincensementioning

confidence: 99%

Molecular evidences on anti‐inflammatory, anticancer, and memory‐boosting effects of frankincense

Khajehdehi

Khalaj‐Kondori

Baradaran

2022

Phytotherapy Research

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Chemical diversity of natural products with drug-like features has attracted much attention from medicine to develop more safe and effective drugs. Their anti-inflammatory, antitumor, analgesic, and other therapeutic properties are sometimes more successful than chemical drugs in controlling disease due to fewer drug resistance and side effects and being more tolerable in a long time. Frankincense, the oleo gum resin extracted from the Boswellia species, contains some of these chemicals. The anti-inflammatory effect of its main ingredient, boswellic acid, has been traditionally used to treat many diseases, mainly those target memory functions. In this review, we have accumulated research evidence from the beneficial effect of Frankincense consumption in memory improvement and the prevention of inflammation and cancer. Besides, we have discussed the molecular pathways mediating the therapeutic effects of this natural supplement.

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Hypothyroidism, Oxidative Stress and Reproduction

Cited by 8 publications

References 93 publications

Thyroid Hormones, Oxidative Stress, and Inflammation

Thyroid Hormones, Oxidative Stress, and Inflammation

Oxidative Stress and Low-Grade Inflammation in Polycystic Ovary Syndrome: Controversies and New Insights

Molecular evidences on anti‐inflammatory, anticancer, and memory‐boosting effects of frankincense

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